Involvement of endogenous testosterone in hepatic steatosis in women with polycystic ovarian syndrome

•In this study, we report that the levels of alanine transaminase (ALT) and aspartate transaminase (AST) were increased in women with polycystic ovarian syndrome (PCOS).•A strong correlation between testosterone and AST levels was also observed.•After treatment with letrozole, an aromatase inhibitor...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2020-11, Vol.204, p.105752-105752, Article 105752
Hauptverfasser:	Li, Tianhe, Zhang, Tingting, Cui, Tianyu, Yang, Yuxi, Liu, Ruixia, Chen, Yi, Yin, Chenghong
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Adult Alanine Alanine transaminase AMP AMP-activated protein kinase AMP-activated protein kinase α AMP-Activated Protein Kinases - metabolism Androgens Androgens - blood Animals Aromatase Aromatase Inhibitors - pharmacology Aspartate transaminase Dihydrotestosterone Dihydrotestosterone - pharmacology Fatty liver Female Hep G2 Cells Hepatocytes Hepatocytes - drug effects Hepatocytes - metabolism HepG2 cells Humans Insulin Insulin resistance Kinases Letrozole Letrozole - pharmacology Liver - drug effects Liver - metabolism Liver diseases Non-alcoholic Fatty Liver Disease - blood Obesity Ovaries Ovary - drug effects Ovary - metabolism Polycystic ovarian syndrome Polycystic ovary syndrome Polycystic Ovary Syndrome - blood Rats, Sprague-Dawley Steatosis Testosterone Testosterone - blood Transaminase Young Adult
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