Liquid chromatography-tandem mass spectrometric assay for TPN171 in human plasma

•UPLC-MS/MS method was first applied to determinate TPN171 in human plasma.•Simple pretreatment by using acetonitrile for plasma samples.•TPN171 was determined with 3.5 min run time and 1 ng/mL lower limit of quantification.•Deuterated isotope internal standard was applied to get a high stability.•I...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2020-11, Vol.191, p.113634-113634, Article 113634
Hauptverfasser:	Zhang, Mengqi, Liu, Haiming, He, Jiajin, Gui, Yuzhou, Qian, Hongjie, Jia, Jingying, Yu, Chen, Wang, Zhen, Shen, Jing Shan, Liu, Gangyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Human plasma LC–MS/MS Protein precipitation TPN171
Online-Zugang:	Volltext
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