Japanese Encephalitis Virus exploits microRNA-155 to suppress the non-canonical NF-κB pathway in human microglial cells

Japanese Encephalitis Virus (JEV) is a single positive strand RNA virus, belongs to the Flaviviridae family. JEV is neurotropic in nature which accounts for 30–50% neurological, psychiatric sequelae and movement disorder, with 20–30% case fatality rate among children or elder population. JEV causes...

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Veröffentlicht in:	Biochimica et biophysica acta. Gene regulatory mechanisms 2020-11, Vol.1863 (11), p.194639-194639, Article 194639
Hauptverfasser:	Rastogi, Meghana, Singh, Sunit Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Encephalitis Virus, Japanese - physiology Encephalitis, Japanese - genetics Encephalitis, Japanese - metabolism Encephalitis, Japanese - virology Gene Expression Gene Expression Regulation Gene Knockdown Techniques Host-Pathogen Interactions - genetics Human microglial cells Humans Immune evasion Japanese Encephalitis Virus Microglia - metabolism microRNA-155 MicroRNAs - genetics Models, Biological NF-kappa B - metabolism Non-canonical NF-κB pathway Pellino E3 ubiquitin ligase Protein Binding RNA Interference Signal Transduction
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