Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx

Current antiviral therapies help keep HBV under control, but they are not curative, as they are unable to eliminate the intracellular viral replication intermediate termed covalently closed circular DNA (cccDNA). Therefore, there remains an urgent need to develop strategies to cure CHB. Functional s...

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Veröffentlicht in:	Journal of hepatology 2021-03, Vol.74 (3), p.522-534
Hauptverfasser:	Cheng, Sheng-Tao, Hu, Jie-Li, Ren, Ji-Hua, Yu, Hai-Bo, Zhong, Shan, Wai Wong, Vincent Kam, Kwan Law, Betty Yuen, Chen, Wei-Xian, Xu, Hong-Mei, Zhang, Zhen-Zhen, Cai, Xue-Fei, Hu, Yuan, Zhang, Wen-Lu, Long, Quan-Xin, Ren, Fang, Zhou, Hong-Zhong, Huang, Ai-Long, Chen, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral activity Antiviral agents Antiviral Agents - administration & dosage cccDNA Chromatin Chronic infection Circular DNA Degradation Deoxyribonucleic acid Dicoumarol Dicumarol - administration & dosage Disease Models, Animal DNA DNA, Circular - isolation & purification DNA, Circular - metabolism HBx HBX protein Hep G2 Cells Hepatitis Hepatitis B Hepatitis B surface antigen Hepatitis B virus Hepatitis B virus - drug effects Hepatitis B virus - metabolism Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - metabolism Hepatitis B, Chronic - virology Hepatocytes - metabolism Humans Liver Mice Mice, Inbred C57BL Mice, Transgenic NAD NAD(P)H Dehydrogenase (Quinone) - antagonists & inhibitors NAD(P)H Dehydrogenase (Quinone) - genetics NAD(P)H Dehydrogenase (Quinone) - metabolism NADPH quinone oxidoreductase Proteasomes Protein stabilisation Proteins Proteolysis - drug effects Quinone oxidoreductase Replication Trans-Activators - metabolism Transcription Transcription, Genetic - drug effects Transfection Treatment Outcome Viral Regulatory and Accessory Proteins - metabolism Virus Replication - drug effects Virus Replication - genetics
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