Risk of dementia in patients with periodontitis and related protective factors: A nationwide retrospective cohort study
Aim We aimed to evaluate the long‐term risk of dementia in patients with periodontitis and its associated factors. Materials and Methods Using Taiwan's National Health Insurance Database, we identified 56,018 patients aged ≥50 years with newly diagnosed periodontitis in 2000–2008. A cohort of 5...
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| Veröffentlicht in: | Journal of clinical periodontology 2020-12, Vol.47 (12), p.1428-1436 |
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| container_title | Journal of clinical periodontology |
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| creator | Lee, Chia‐Yen Chang, Chuen‐Chau Lin, Chao‐Shun Yeh, Chun‐Chieh Hu, Chaur‐Jong Wu, Ching‐Zong Chen, Ta‐Liang Liao, Chien‐Chang |
| description | Aim
We aimed to evaluate the long‐term risk of dementia in patients with periodontitis and its associated factors.
Materials and Methods
Using Taiwan's National Health Insurance Database, we identified 56,018 patients aged ≥50 years with newly diagnosed periodontitis in 2000–2008. A cohort of 56,018 adults without periodontitis was selected for comparison, with matching by age and sex. Both cohorts were followed from 2000 to the end of 2013, and incident dementia was identified during the follow‐up period. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of dementia associated with periodontitis were calculated in the multivariate regressions.
Results
Periodontitis was associated with dementia risk (HR: 1.79, 95% CI: 1.67–1.93), and the association between periodontitis and dementia risk was significant in men, women, and people aged more than 60 years. Among patients with periodontitis, the use of statins (HR: 0.78, 95% CI: 0.71–0.87), metformin (HR: 0.53, 95% CI: 0.44–0.62), and influenza vaccination (HR: 0.67, 95% CI: 0.61–0.74) were associated with a reduced risk of dementia, while diabetes, mental disorders, and stroke were major significant risk factors.
Conclusions
Periodontitis was a risk factor for dementia, while the use of statins and metformin may reduce the risk of dementia. |
| doi_str_mv | 10.1111/jcpe.13372 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2447309407</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2447309407</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3572-2b6b20dd993e31526ebae90f811d406e1ead0e12f70f7f64c5d5fcace0f5cab53</originalsourceid><addsrcrecordid>eNp90c9rFDEUB_AgFrtWL_4BEvBShKnvJTMZx1tZ6o9SqIiCtyGTvNCss5Mxybjsf2_qrh48NJcQ8smX9_IYe4FwgWW92ZiZLlDKVjxiK1QAFTT4_TFbgQRZqa7tTtnTlDYA2Eopn7BTKboOAZsV233x6QcPjlva0pS95n7is86-HBLf-XzHZ4o-2FAus09cT5ZHGnUmy-cYMpnsfxF32uQQ0zt-yafyOkw7b6nAHEOaj8aEuxAzT3mx-2fsxOkx0fPjfsa-vb_6uv5Y3dx--LS-vKmMbFpRiUENAqztOkkSG6Fo0NSBe4toa1CEpC0QCteCa52qTWMbZ7QhcI3RQyPP2Pkht9T6c6GU-61PhsZRTxSW1Iu6biV0NbSFvvqPbsISp1JdUaquFQqFRb0-KFM6S5FcP0e_1XHfI_T34-jvx9H_GUfBL4-Ry7Al-4_-_f8C8AB2fqT9A1H99frz1SH0N9bql6E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2464461261</pqid></control><display><type>article</type><title>Risk of dementia in patients with periodontitis and related protective factors: A nationwide retrospective cohort study</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Lee, Chia‐Yen ; Chang, Chuen‐Chau ; Lin, Chao‐Shun ; Yeh, Chun‐Chieh ; Hu, Chaur‐Jong ; Wu, Ching‐Zong ; Chen, Ta‐Liang ; Liao, Chien‐Chang</creator><creatorcontrib>Lee, Chia‐Yen ; Chang, Chuen‐Chau ; Lin, Chao‐Shun ; Yeh, Chun‐Chieh ; Hu, Chaur‐Jong ; Wu, Ching‐Zong ; Chen, Ta‐Liang ; Liao, Chien‐Chang</creatorcontrib><description>Aim
We aimed to evaluate the long‐term risk of dementia in patients with periodontitis and its associated factors.
Materials and Methods
Using Taiwan's National Health Insurance Database, we identified 56,018 patients aged ≥50 years with newly diagnosed periodontitis in 2000–2008. A cohort of 56,018 adults without periodontitis was selected for comparison, with matching by age and sex. Both cohorts were followed from 2000 to the end of 2013, and incident dementia was identified during the follow‐up period. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of dementia associated with periodontitis were calculated in the multivariate regressions.
Results
Periodontitis was associated with dementia risk (HR: 1.79, 95% CI: 1.67–1.93), and the association between periodontitis and dementia risk was significant in men, women, and people aged more than 60 years. Among patients with periodontitis, the use of statins (HR: 0.78, 95% CI: 0.71–0.87), metformin (HR: 0.53, 95% CI: 0.44–0.62), and influenza vaccination (HR: 0.67, 95% CI: 0.61–0.74) were associated with a reduced risk of dementia, while diabetes, mental disorders, and stroke were major significant risk factors.
Conclusions
Periodontitis was a risk factor for dementia, while the use of statins and metformin may reduce the risk of dementia.</description><identifier>ISSN: 0303-6979</identifier><identifier>EISSN: 1600-051X</identifier><identifier>DOI: 10.1111/jcpe.13372</identifier><identifier>PMID: 32991015</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Antidiabetics ; Cohort analysis ; Cohort Studies ; Dementia ; Dementia - epidemiology ; Dementia disorders ; Dentistry ; Diabetes mellitus ; Female ; Gum disease ; Humans ; Incidence ; Influenza ; influenza vaccination ; Male ; Mental disorders ; Metformin ; Periodontitis ; Periodontitis - complications ; Periodontitis - epidemiology ; Proportional Hazards Models ; Protective Factors ; Retrospective Studies ; Risk Factors ; Statins ; Taiwan - epidemiology ; Vaccination</subject><ispartof>Journal of clinical periodontology, 2020-12, Vol.47 (12), p.1428-1436</ispartof><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3572-2b6b20dd993e31526ebae90f811d406e1ead0e12f70f7f64c5d5fcace0f5cab53</citedby><cites>FETCH-LOGICAL-c3572-2b6b20dd993e31526ebae90f811d406e1ead0e12f70f7f64c5d5fcace0f5cab53</cites><orcidid>0000-0001-6694-0730</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjcpe.13372$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjcpe.13372$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32991015$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Chia‐Yen</creatorcontrib><creatorcontrib>Chang, Chuen‐Chau</creatorcontrib><creatorcontrib>Lin, Chao‐Shun</creatorcontrib><creatorcontrib>Yeh, Chun‐Chieh</creatorcontrib><creatorcontrib>Hu, Chaur‐Jong</creatorcontrib><creatorcontrib>Wu, Ching‐Zong</creatorcontrib><creatorcontrib>Chen, Ta‐Liang</creatorcontrib><creatorcontrib>Liao, Chien‐Chang</creatorcontrib><title>Risk of dementia in patients with periodontitis and related protective factors: A nationwide retrospective cohort study</title><title>Journal of clinical periodontology</title><addtitle>J Clin Periodontol</addtitle><description>Aim
We aimed to evaluate the long‐term risk of dementia in patients with periodontitis and its associated factors.
Materials and Methods
Using Taiwan's National Health Insurance Database, we identified 56,018 patients aged ≥50 years with newly diagnosed periodontitis in 2000–2008. A cohort of 56,018 adults without periodontitis was selected for comparison, with matching by age and sex. Both cohorts were followed from 2000 to the end of 2013, and incident dementia was identified during the follow‐up period. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of dementia associated with periodontitis were calculated in the multivariate regressions.
Results
Periodontitis was associated with dementia risk (HR: 1.79, 95% CI: 1.67–1.93), and the association between periodontitis and dementia risk was significant in men, women, and people aged more than 60 years. Among patients with periodontitis, the use of statins (HR: 0.78, 95% CI: 0.71–0.87), metformin (HR: 0.53, 95% CI: 0.44–0.62), and influenza vaccination (HR: 0.67, 95% CI: 0.61–0.74) were associated with a reduced risk of dementia, while diabetes, mental disorders, and stroke were major significant risk factors.
Conclusions
Periodontitis was a risk factor for dementia, while the use of statins and metformin may reduce the risk of dementia.</description><subject>Adult</subject><subject>Aged</subject><subject>Antidiabetics</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Dementia</subject><subject>Dementia - epidemiology</subject><subject>Dementia disorders</subject><subject>Dentistry</subject><subject>Diabetes mellitus</subject><subject>Female</subject><subject>Gum disease</subject><subject>Humans</subject><subject>Incidence</subject><subject>Influenza</subject><subject>influenza vaccination</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Metformin</subject><subject>Periodontitis</subject><subject>Periodontitis - complications</subject><subject>Periodontitis - epidemiology</subject><subject>Proportional Hazards Models</subject><subject>Protective Factors</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Statins</subject><subject>Taiwan - epidemiology</subject><subject>Vaccination</subject><issn>0303-6979</issn><issn>1600-051X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90c9rFDEUB_AgFrtWL_4BEvBShKnvJTMZx1tZ6o9SqIiCtyGTvNCss5Mxybjsf2_qrh48NJcQ8smX9_IYe4FwgWW92ZiZLlDKVjxiK1QAFTT4_TFbgQRZqa7tTtnTlDYA2Eopn7BTKboOAZsV233x6QcPjlva0pS95n7is86-HBLf-XzHZ4o-2FAus09cT5ZHGnUmy-cYMpnsfxF32uQQ0zt-yafyOkw7b6nAHEOaj8aEuxAzT3mx-2fsxOkx0fPjfsa-vb_6uv5Y3dx--LS-vKmMbFpRiUENAqztOkkSG6Fo0NSBe4toa1CEpC0QCteCa52qTWMbZ7QhcI3RQyPP2Pkht9T6c6GU-61PhsZRTxSW1Iu6biV0NbSFvvqPbsISp1JdUaquFQqFRb0-KFM6S5FcP0e_1XHfI_T34-jvx9H_GUfBL4-Ry7Al-4_-_f8C8AB2fqT9A1H99frz1SH0N9bql6E</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Lee, Chia‐Yen</creator><creator>Chang, Chuen‐Chau</creator><creator>Lin, Chao‐Shun</creator><creator>Yeh, Chun‐Chieh</creator><creator>Hu, Chaur‐Jong</creator><creator>Wu, Ching‐Zong</creator><creator>Chen, Ta‐Liang</creator><creator>Liao, Chien‐Chang</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6694-0730</orcidid></search><sort><creationdate>202012</creationdate><title>Risk of dementia in patients with periodontitis and related protective factors: A nationwide retrospective cohort study</title><author>Lee, Chia‐Yen ; Chang, Chuen‐Chau ; Lin, Chao‐Shun ; Yeh, Chun‐Chieh ; Hu, Chaur‐Jong ; Wu, Ching‐Zong ; Chen, Ta‐Liang ; Liao, Chien‐Chang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3572-2b6b20dd993e31526ebae90f811d406e1ead0e12f70f7f64c5d5fcace0f5cab53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antidiabetics</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Dementia</topic><topic>Dementia - epidemiology</topic><topic>Dementia disorders</topic><topic>Dentistry</topic><topic>Diabetes mellitus</topic><topic>Female</topic><topic>Gum disease</topic><topic>Humans</topic><topic>Incidence</topic><topic>Influenza</topic><topic>influenza vaccination</topic><topic>Male</topic><topic>Mental disorders</topic><topic>Metformin</topic><topic>Periodontitis</topic><topic>Periodontitis - complications</topic><topic>Periodontitis - epidemiology</topic><topic>Proportional Hazards Models</topic><topic>Protective Factors</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Statins</topic><topic>Taiwan - epidemiology</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Chia‐Yen</creatorcontrib><creatorcontrib>Chang, Chuen‐Chau</creatorcontrib><creatorcontrib>Lin, Chao‐Shun</creatorcontrib><creatorcontrib>Yeh, Chun‐Chieh</creatorcontrib><creatorcontrib>Hu, Chaur‐Jong</creatorcontrib><creatorcontrib>Wu, Ching‐Zong</creatorcontrib><creatorcontrib>Chen, Ta‐Liang</creatorcontrib><creatorcontrib>Liao, Chien‐Chang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical periodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Chia‐Yen</au><au>Chang, Chuen‐Chau</au><au>Lin, Chao‐Shun</au><au>Yeh, Chun‐Chieh</au><au>Hu, Chaur‐Jong</au><au>Wu, Ching‐Zong</au><au>Chen, Ta‐Liang</au><au>Liao, Chien‐Chang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of dementia in patients with periodontitis and related protective factors: A nationwide retrospective cohort study</atitle><jtitle>Journal of clinical periodontology</jtitle><addtitle>J Clin Periodontol</addtitle><date>2020-12</date><risdate>2020</risdate><volume>47</volume><issue>12</issue><spage>1428</spage><epage>1436</epage><pages>1428-1436</pages><issn>0303-6979</issn><eissn>1600-051X</eissn><abstract>Aim
We aimed to evaluate the long‐term risk of dementia in patients with periodontitis and its associated factors.
Materials and Methods
Using Taiwan's National Health Insurance Database, we identified 56,018 patients aged ≥50 years with newly diagnosed periodontitis in 2000–2008. A cohort of 56,018 adults without periodontitis was selected for comparison, with matching by age and sex. Both cohorts were followed from 2000 to the end of 2013, and incident dementia was identified during the follow‐up period. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of dementia associated with periodontitis were calculated in the multivariate regressions.
Results
Periodontitis was associated with dementia risk (HR: 1.79, 95% CI: 1.67–1.93), and the association between periodontitis and dementia risk was significant in men, women, and people aged more than 60 years. Among patients with periodontitis, the use of statins (HR: 0.78, 95% CI: 0.71–0.87), metformin (HR: 0.53, 95% CI: 0.44–0.62), and influenza vaccination (HR: 0.67, 95% CI: 0.61–0.74) were associated with a reduced risk of dementia, while diabetes, mental disorders, and stroke were major significant risk factors.
Conclusions
Periodontitis was a risk factor for dementia, while the use of statins and metformin may reduce the risk of dementia.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>32991015</pmid><doi>10.1111/jcpe.13372</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6694-0730</orcidid></addata></record> |
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| ispartof | Journal of clinical periodontology, 2020-12, Vol.47 (12), p.1428-1436 |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Aged Antidiabetics Cohort analysis Cohort Studies Dementia Dementia - epidemiology Dementia disorders Dentistry Diabetes mellitus Female Gum disease Humans Incidence Influenza influenza vaccination Male Mental disorders Metformin Periodontitis Periodontitis - complications Periodontitis - epidemiology Proportional Hazards Models Protective Factors Retrospective Studies Risk Factors Statins Taiwan - epidemiology Vaccination |
| title | Risk of dementia in patients with periodontitis and related protective factors: A nationwide retrospective cohort study |
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