Is there an association between sarcoidosis and atherosclerosis?
Sarcoidosis is a multisystemic chronic inflammatory disease that the specific etiology is not known clearly. The aim of this study is, to investigate the presence of subclinical atherosclerosis and endothelial dysfunction by using carotid intima-media thickness and flow-mediated dilatation measureme...
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| Veröffentlicht in: | The International Journal of Cardiovascular Imaging 2021-02, Vol.37 (2), p.559-567 |
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| container_title | The International Journal of Cardiovascular Imaging |
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| creator | Yilmaz, Yusuf Kul, Seref Kavas, Murat Erman, Hayriye Aciksari, Gonul Ozcan, Fatma Betul Yalcinkaya, Emre Kanbay, Asiye Caliskan, Mustafa |
| description | Sarcoidosis is a multisystemic chronic inflammatory disease that the specific etiology is not known clearly. The aim of this study is, to investigate the presence of subclinical atherosclerosis and endothelial dysfunction by using carotid intima-media thickness and flow-mediated dilatation measurements, measuring the copeptin values, which is a stress marker, and interpreting the association of copeptin values with these two variables in sarcoidosis patients without conventional risk factors for coronary artery disease. Seventy-four patients (50 f, 24 m) with histopathological diagnosis of sarcoidosis and 60 healthy volunteers (35 f, 25 m) with similar sociodemographic characteristics were included in this study. CIMT, FMD, and serum copeptin levels of all participants were measured. The values of CIMT and Copeptin in sarcoidosis patients were significantly higher (p = 0.001, p |
| doi_str_mv | 10.1007/s10554-020-02041-x |
| format | Article |
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The aim of this study is, to investigate the presence of subclinical atherosclerosis and endothelial dysfunction by using carotid intima-media thickness and flow-mediated dilatation measurements, measuring the copeptin values, which is a stress marker, and interpreting the association of copeptin values with these two variables in sarcoidosis patients without conventional risk factors for coronary artery disease. Seventy-four patients (50 f, 24 m) with histopathological diagnosis of sarcoidosis and 60 healthy volunteers (35 f, 25 m) with similar sociodemographic characteristics were included in this study. CIMT, FMD, and serum copeptin levels of all participants were measured. The values of CIMT and Copeptin in sarcoidosis patients were significantly higher (p = 0.001, p < 0.001 respectively), and FMD was significantly lower (p = 0.01) than the control group. In sarcoidosis patients not significant correlation found among CIMT with copeptin (r: 0.16, p = 0.18) and FMD with copeptin (r: 0.01, p = 0.96). With the demonstration of the presence of subclinical atherosclerosis and endothelial dysfunction, we suggest; sarcoidosis patients may be followed more closely in terms of cardiovascular diseases. And new studies are needed to investigate the pathophysiology and the effects of high copeptin levels in sarcoidosis patients.</description><identifier>ISSN: 1569-5794</identifier><identifier>EISSN: 1573-0743</identifier><identifier>EISSN: 1875-8312</identifier><identifier>DOI: 10.1007/s10554-020-02041-x</identifier><identifier>PMID: 32989613</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Arteriosclerosis ; Atherosclerosis ; Cardiac Imaging ; Cardiology ; Cardiovascular disease ; Cardiovascular diseases ; Coronary artery ; Coronary artery disease ; Etiology ; Heart diseases ; Imaging ; Inflammatory diseases ; Medicine ; Medicine & Public Health ; Original Paper ; Radiology ; Risk analysis ; Risk factors ; Sarcoidosis</subject><ispartof>The International Journal of Cardiovascular Imaging, 2021-02, Vol.37 (2), p.559-567</ispartof><rights>Springer Nature B.V. 2020</rights><rights>Springer Nature B.V. 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-f7ec624e094054f1bc90421315d6ee4cef8c5ad91ce92fec6b7bc71fa42a5add3</citedby><cites>FETCH-LOGICAL-c375t-f7ec624e094054f1bc90421315d6ee4cef8c5ad91ce92fec6b7bc71fa42a5add3</cites><orcidid>0000-0002-6676-2740</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10554-020-02041-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10554-020-02041-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32989613$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yilmaz, Yusuf</creatorcontrib><creatorcontrib>Kul, Seref</creatorcontrib><creatorcontrib>Kavas, Murat</creatorcontrib><creatorcontrib>Erman, Hayriye</creatorcontrib><creatorcontrib>Aciksari, Gonul</creatorcontrib><creatorcontrib>Ozcan, Fatma Betul</creatorcontrib><creatorcontrib>Yalcinkaya, Emre</creatorcontrib><creatorcontrib>Kanbay, Asiye</creatorcontrib><creatorcontrib>Caliskan, Mustafa</creatorcontrib><title>Is there an association between sarcoidosis and atherosclerosis?</title><title>The International Journal of Cardiovascular Imaging</title><addtitle>Int J Cardiovasc Imaging</addtitle><addtitle>Int J Cardiovasc Imaging</addtitle><description>Sarcoidosis is a multisystemic chronic inflammatory disease that the specific etiology is not known clearly. The aim of this study is, to investigate the presence of subclinical atherosclerosis and endothelial dysfunction by using carotid intima-media thickness and flow-mediated dilatation measurements, measuring the copeptin values, which is a stress marker, and interpreting the association of copeptin values with these two variables in sarcoidosis patients without conventional risk factors for coronary artery disease. Seventy-four patients (50 f, 24 m) with histopathological diagnosis of sarcoidosis and 60 healthy volunteers (35 f, 25 m) with similar sociodemographic characteristics were included in this study. CIMT, FMD, and serum copeptin levels of all participants were measured. The values of CIMT and Copeptin in sarcoidosis patients were significantly higher (p = 0.001, p < 0.001 respectively), and FMD was significantly lower (p = 0.01) than the control group. In sarcoidosis patients not significant correlation found among CIMT with copeptin (r: 0.16, p = 0.18) and FMD with copeptin (r: 0.01, p = 0.96). With the demonstration of the presence of subclinical atherosclerosis and endothelial dysfunction, we suggest; sarcoidosis patients may be followed more closely in terms of cardiovascular diseases. And new studies are needed to investigate the pathophysiology and the effects of high copeptin levels in sarcoidosis patients.</description><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Cardiac Imaging</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Etiology</subject><subject>Heart diseases</subject><subject>Imaging</subject><subject>Inflammatory diseases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Paper</subject><subject>Radiology</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Sarcoidosis</subject><issn>1569-5794</issn><issn>1573-0743</issn><issn>1875-8312</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kLtOwzAUhi0EoqXwAgwoEgtLwNe4ngBVXCpVYoHZcpwTSNXGJScR5e1xCBeJgcH2kf2d3_ZHyDGj54xSfYGMKiVTymk_JEu3O2TMlBYp1VLs9nVmUqWNHJEDxCWlEeNin4wEN1OTMTEmV3NM2hdoIHF14hCDr1xbhTrJoX0DqBN0jQ9VEbDCiBSJ6-mAftXPFV4ekr3SrRCOvtYJebq9eZzdp4uHu_nsepF6oVWblhp8xiVQI6mSJcu9oZIzwVSRAUgP5dQrVxjmwfAysrnOvWalk9zF_UJMyNmQu2nCawfY2nWFHlYrV0Po0HIptaBTIVlET_-gy9A1dXxdpAxnnFMtIsUHysePYAOl3TTV2jXvllHb-7WDXxul2U-_dhubTr6iu3wNxU_Lt9AIiAHAeFQ_Q_N79z-xH8sThk0</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Yilmaz, Yusuf</creator><creator>Kul, Seref</creator><creator>Kavas, Murat</creator><creator>Erman, Hayriye</creator><creator>Aciksari, Gonul</creator><creator>Ozcan, Fatma Betul</creator><creator>Yalcinkaya, Emre</creator><creator>Kanbay, Asiye</creator><creator>Caliskan, Mustafa</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6676-2740</orcidid></search><sort><creationdate>20210201</creationdate><title>Is there an association between sarcoidosis and atherosclerosis?</title><author>Yilmaz, Yusuf ; 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The aim of this study is, to investigate the presence of subclinical atherosclerosis and endothelial dysfunction by using carotid intima-media thickness and flow-mediated dilatation measurements, measuring the copeptin values, which is a stress marker, and interpreting the association of copeptin values with these two variables in sarcoidosis patients without conventional risk factors for coronary artery disease. Seventy-four patients (50 f, 24 m) with histopathological diagnosis of sarcoidosis and 60 healthy volunteers (35 f, 25 m) with similar sociodemographic characteristics were included in this study. CIMT, FMD, and serum copeptin levels of all participants were measured. The values of CIMT and Copeptin in sarcoidosis patients were significantly higher (p = 0.001, p < 0.001 respectively), and FMD was significantly lower (p = 0.01) than the control group. In sarcoidosis patients not significant correlation found among CIMT with copeptin (r: 0.16, p = 0.18) and FMD with copeptin (r: 0.01, p = 0.96). With the demonstration of the presence of subclinical atherosclerosis and endothelial dysfunction, we suggest; sarcoidosis patients may be followed more closely in terms of cardiovascular diseases. And new studies are needed to investigate the pathophysiology and the effects of high copeptin levels in sarcoidosis patients.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>32989613</pmid><doi>10.1007/s10554-020-02041-x</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6676-2740</orcidid></addata></record> |
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| subjects | Arteriosclerosis Atherosclerosis Cardiac Imaging Cardiology Cardiovascular disease Cardiovascular diseases Coronary artery Coronary artery disease Etiology Heart diseases Imaging Inflammatory diseases Medicine Medicine & Public Health Original Paper Radiology Risk analysis Risk factors Sarcoidosis |
| title | Is there an association between sarcoidosis and atherosclerosis? |
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