Functional correlations between CXCL10/IP10 gene polymorphisms and risk of Kawasaki disease
Background Kawasaki disease (KD) is an acute systemic vasculitis syndrome with unknown pathogen. The immune system has been suggested to involve in the pathogenesis in KD. IP10 is a chemoattractant for initiating T‐cell activation. The aim of this study was to investigate the association between gen...
Gespeichert in:
| Veröffentlicht in: | Pediatric allergy and immunology 2021-02, Vol.32 (2), p.363-370 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 370 |
|---|---|
| container_issue | 2 |
| container_start_page | 363 |
| container_title | Pediatric allergy and immunology |
| container_volume | 32 |
| creator | Hsu, Yu‐Wen Lu, Hsing‐Fang Chou, Wan‐Hsuan Kuo, Ho‐Chang Chang, Wei‐Chiao Atanaskovic‐Markovic, Marina |
| description | Background
Kawasaki disease (KD) is an acute systemic vasculitis syndrome with unknown pathogen. The immune system has been suggested to involve in the pathogenesis in KD. IP10 is a chemoattractant for initiating T‐cell activation. The aim of this study was to investigate the association between genetic polymorphisms of IP10 and KD.
Methods
A total of 354 KD patients and 1,709 control subjects (709 subjects in cohort 1 and 1,000 subjects in cohort 2) were enrolled in this study. Four tagging single nucleotide polymorphisms (rs3921, rs4256246, rs4508917, and rs4386624) were chosen for genotyping.
Results
Our results indicated that CC genotype of rs3921 and GG genotype of rs4386624 had higher frequency in KD patients compared to control. In addition, higher plasma IP10 level was observed in CC genotype of rs3921 than CG genotype and GG genotype. C/G haplotype carriers of rs3921/rs4386624 had 5.48‐fold risk for KD compared to G/C haplotype carriers. Two‐locus analysis further showed the combinatorial effects of rs3921 and rs4386624 in KD susceptibility.
Conclusions
This study indicated the close correlation between IP10 and the risk of Kawasaki disease. |
| doi_str_mv | 10.1111/pai.13381 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2447308212</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2447308212</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3531-6e0890e25b8ec85cf64633f4c33b95d37f691267c44f4ed70c55380f10acf9c43</originalsourceid><addsrcrecordid>eNp10MFq3DAQBmARUppt0kNeIAhyaQ_OajyyLR3D0rRLF5JDAoUejFYetUpsy5HWLPv29XbTHgKZyzDw8cP8jJ2DuIJp5oPxV4Co4IjNALXOUKA6ZjOhRZGVUFQn7ENKj0JAhSW8ZyeYa6WVwBn7eTP2duNDb1puQ4zUmv2V-Jo2W6KeL34sViDmyzsQ_Bf1xIfQ7roQh98-dYmbvuHRpyceHP9utiaZJ88bn8gkOmPvnGkTfXzZp-zh5sv94lu2uv26XFyvMosFQlaSUFpQXqwVWVVYV8oS0UmLuNZFg5UrNeRlZaV0kppK2KJAJRwIY522Ek_Zp0PuEMPzSGlTdz5ZalvTUxhTnUtZoVA55BO9fEUfwxin5_dKSaigVDipzwdlY0gpkquH6DsTdzWIet94PTVe_218shcvieO6o-a__FfxBOYHsPUt7d5Oqu-ul4fIP85jiFU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2484171683</pqid></control><display><type>article</type><title>Functional correlations between CXCL10/IP10 gene polymorphisms and risk of Kawasaki disease</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Hsu, Yu‐Wen ; Lu, Hsing‐Fang ; Chou, Wan‐Hsuan ; Kuo, Ho‐Chang ; Chang, Wei‐Chiao ; Atanaskovic‐Markovic, Marina</creator><creatorcontrib>Hsu, Yu‐Wen ; Lu, Hsing‐Fang ; Chou, Wan‐Hsuan ; Kuo, Ho‐Chang ; Chang, Wei‐Chiao ; Atanaskovic‐Markovic, Marina</creatorcontrib><description>Background
Kawasaki disease (KD) is an acute systemic vasculitis syndrome with unknown pathogen. The immune system has been suggested to involve in the pathogenesis in KD. IP10 is a chemoattractant for initiating T‐cell activation. The aim of this study was to investigate the association between genetic polymorphisms of IP10 and KD.
Methods
A total of 354 KD patients and 1,709 control subjects (709 subjects in cohort 1 and 1,000 subjects in cohort 2) were enrolled in this study. Four tagging single nucleotide polymorphisms (rs3921, rs4256246, rs4508917, and rs4386624) were chosen for genotyping.
Results
Our results indicated that CC genotype of rs3921 and GG genotype of rs4386624 had higher frequency in KD patients compared to control. In addition, higher plasma IP10 level was observed in CC genotype of rs3921 than CG genotype and GG genotype. C/G haplotype carriers of rs3921/rs4386624 had 5.48‐fold risk for KD compared to G/C haplotype carriers. Two‐locus analysis further showed the combinatorial effects of rs3921 and rs4386624 in KD susceptibility.
Conclusions
This study indicated the close correlation between IP10 and the risk of Kawasaki disease.</description><identifier>ISSN: 0905-6157</identifier><identifier>EISSN: 1399-3038</identifier><identifier>DOI: 10.1111/pai.13381</identifier><identifier>PMID: 32989803</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Case-Control Studies ; Cell activation ; Chemokine CXCL10 - genetics ; CXCL10 ; CXCL10 protein ; Gene Frequency ; Gene polymorphism ; Genetic Predisposition to Disease ; Genotype ; Genotype & phenotype ; Genotyping ; Haplotypes ; Humans ; Immune system ; in silico analysis ; IP10 ; Kawasaki disease ; Mucocutaneous lymph node syndrome ; Mucocutaneous Lymph Node Syndrome - genetics ; Polymorphism, Single Nucleotide ; Single-nucleotide polymorphism ; SNP association study ; Systemic vasculitis</subject><ispartof>Pediatric allergy and immunology, 2021-02, Vol.32 (2), p.363-370</ispartof><rights>2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.</rights><rights>Copyright © 2021 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-6e0890e25b8ec85cf64633f4c33b95d37f691267c44f4ed70c55380f10acf9c43</citedby><cites>FETCH-LOGICAL-c3531-6e0890e25b8ec85cf64633f4c33b95d37f691267c44f4ed70c55380f10acf9c43</cites><orcidid>0000-0002-6126-8938 ; 0000-0002-8573-5924 ; 0000-0002-3295-2984</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpai.13381$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpai.13381$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32989803$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsu, Yu‐Wen</creatorcontrib><creatorcontrib>Lu, Hsing‐Fang</creatorcontrib><creatorcontrib>Chou, Wan‐Hsuan</creatorcontrib><creatorcontrib>Kuo, Ho‐Chang</creatorcontrib><creatorcontrib>Chang, Wei‐Chiao</creatorcontrib><creatorcontrib>Atanaskovic‐Markovic, Marina</creatorcontrib><title>Functional correlations between CXCL10/IP10 gene polymorphisms and risk of Kawasaki disease</title><title>Pediatric allergy and immunology</title><addtitle>Pediatr Allergy Immunol</addtitle><description>Background
Kawasaki disease (KD) is an acute systemic vasculitis syndrome with unknown pathogen. The immune system has been suggested to involve in the pathogenesis in KD. IP10 is a chemoattractant for initiating T‐cell activation. The aim of this study was to investigate the association between genetic polymorphisms of IP10 and KD.
Methods
A total of 354 KD patients and 1,709 control subjects (709 subjects in cohort 1 and 1,000 subjects in cohort 2) were enrolled in this study. Four tagging single nucleotide polymorphisms (rs3921, rs4256246, rs4508917, and rs4386624) were chosen for genotyping.
Results
Our results indicated that CC genotype of rs3921 and GG genotype of rs4386624 had higher frequency in KD patients compared to control. In addition, higher plasma IP10 level was observed in CC genotype of rs3921 than CG genotype and GG genotype. C/G haplotype carriers of rs3921/rs4386624 had 5.48‐fold risk for KD compared to G/C haplotype carriers. Two‐locus analysis further showed the combinatorial effects of rs3921 and rs4386624 in KD susceptibility.
Conclusions
This study indicated the close correlation between IP10 and the risk of Kawasaki disease.</description><subject>Case-Control Studies</subject><subject>Cell activation</subject><subject>Chemokine CXCL10 - genetics</subject><subject>CXCL10</subject><subject>CXCL10 protein</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Genotyping</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Immune system</subject><subject>in silico analysis</subject><subject>IP10</subject><subject>Kawasaki disease</subject><subject>Mucocutaneous lymph node syndrome</subject><subject>Mucocutaneous Lymph Node Syndrome - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Single-nucleotide polymorphism</subject><subject>SNP association study</subject><subject>Systemic vasculitis</subject><issn>0905-6157</issn><issn>1399-3038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MFq3DAQBmARUppt0kNeIAhyaQ_OajyyLR3D0rRLF5JDAoUejFYetUpsy5HWLPv29XbTHgKZyzDw8cP8jJ2DuIJp5oPxV4Co4IjNALXOUKA6ZjOhRZGVUFQn7ENKj0JAhSW8ZyeYa6WVwBn7eTP2duNDb1puQ4zUmv2V-Jo2W6KeL34sViDmyzsQ_Bf1xIfQ7roQh98-dYmbvuHRpyceHP9utiaZJ88bn8gkOmPvnGkTfXzZp-zh5sv94lu2uv26XFyvMosFQlaSUFpQXqwVWVVYV8oS0UmLuNZFg5UrNeRlZaV0kppK2KJAJRwIY522Ek_Zp0PuEMPzSGlTdz5ZalvTUxhTnUtZoVA55BO9fEUfwxin5_dKSaigVDipzwdlY0gpkquH6DsTdzWIet94PTVe_218shcvieO6o-a__FfxBOYHsPUt7d5Oqu-ul4fIP85jiFU</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Hsu, Yu‐Wen</creator><creator>Lu, Hsing‐Fang</creator><creator>Chou, Wan‐Hsuan</creator><creator>Kuo, Ho‐Chang</creator><creator>Chang, Wei‐Chiao</creator><creator>Atanaskovic‐Markovic, Marina</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6126-8938</orcidid><orcidid>https://orcid.org/0000-0002-8573-5924</orcidid><orcidid>https://orcid.org/0000-0002-3295-2984</orcidid></search><sort><creationdate>202102</creationdate><title>Functional correlations between CXCL10/IP10 gene polymorphisms and risk of Kawasaki disease</title><author>Hsu, Yu‐Wen ; Lu, Hsing‐Fang ; Chou, Wan‐Hsuan ; Kuo, Ho‐Chang ; Chang, Wei‐Chiao ; Atanaskovic‐Markovic, Marina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-6e0890e25b8ec85cf64633f4c33b95d37f691267c44f4ed70c55380f10acf9c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Case-Control Studies</topic><topic>Cell activation</topic><topic>Chemokine CXCL10 - genetics</topic><topic>CXCL10</topic><topic>CXCL10 protein</topic><topic>Gene Frequency</topic><topic>Gene polymorphism</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Genotyping</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Immune system</topic><topic>in silico analysis</topic><topic>IP10</topic><topic>Kawasaki disease</topic><topic>Mucocutaneous lymph node syndrome</topic><topic>Mucocutaneous Lymph Node Syndrome - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Single-nucleotide polymorphism</topic><topic>SNP association study</topic><topic>Systemic vasculitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsu, Yu‐Wen</creatorcontrib><creatorcontrib>Lu, Hsing‐Fang</creatorcontrib><creatorcontrib>Chou, Wan‐Hsuan</creatorcontrib><creatorcontrib>Kuo, Ho‐Chang</creatorcontrib><creatorcontrib>Chang, Wei‐Chiao</creatorcontrib><creatorcontrib>Atanaskovic‐Markovic, Marina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric allergy and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsu, Yu‐Wen</au><au>Lu, Hsing‐Fang</au><au>Chou, Wan‐Hsuan</au><au>Kuo, Ho‐Chang</au><au>Chang, Wei‐Chiao</au><au>Atanaskovic‐Markovic, Marina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional correlations between CXCL10/IP10 gene polymorphisms and risk of Kawasaki disease</atitle><jtitle>Pediatric allergy and immunology</jtitle><addtitle>Pediatr Allergy Immunol</addtitle><date>2021-02</date><risdate>2021</risdate><volume>32</volume><issue>2</issue><spage>363</spage><epage>370</epage><pages>363-370</pages><issn>0905-6157</issn><eissn>1399-3038</eissn><abstract>Background
Kawasaki disease (KD) is an acute systemic vasculitis syndrome with unknown pathogen. The immune system has been suggested to involve in the pathogenesis in KD. IP10 is a chemoattractant for initiating T‐cell activation. The aim of this study was to investigate the association between genetic polymorphisms of IP10 and KD.
Methods
A total of 354 KD patients and 1,709 control subjects (709 subjects in cohort 1 and 1,000 subjects in cohort 2) were enrolled in this study. Four tagging single nucleotide polymorphisms (rs3921, rs4256246, rs4508917, and rs4386624) were chosen for genotyping.
Results
Our results indicated that CC genotype of rs3921 and GG genotype of rs4386624 had higher frequency in KD patients compared to control. In addition, higher plasma IP10 level was observed in CC genotype of rs3921 than CG genotype and GG genotype. C/G haplotype carriers of rs3921/rs4386624 had 5.48‐fold risk for KD compared to G/C haplotype carriers. Two‐locus analysis further showed the combinatorial effects of rs3921 and rs4386624 in KD susceptibility.
Conclusions
This study indicated the close correlation between IP10 and the risk of Kawasaki disease.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32989803</pmid><doi>10.1111/pai.13381</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6126-8938</orcidid><orcidid>https://orcid.org/0000-0002-8573-5924</orcidid><orcidid>https://orcid.org/0000-0002-3295-2984</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0905-6157 |
| ispartof | Pediatric allergy and immunology, 2021-02, Vol.32 (2), p.363-370 |
| issn | 0905-6157 1399-3038 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2447308212 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Case-Control Studies Cell activation Chemokine CXCL10 - genetics CXCL10 CXCL10 protein Gene Frequency Gene polymorphism Genetic Predisposition to Disease Genotype Genotype & phenotype Genotyping Haplotypes Humans Immune system in silico analysis IP10 Kawasaki disease Mucocutaneous lymph node syndrome Mucocutaneous Lymph Node Syndrome - genetics Polymorphism, Single Nucleotide Single-nucleotide polymorphism SNP association study Systemic vasculitis |
| title | Functional correlations between CXCL10/IP10 gene polymorphisms and risk of Kawasaki disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T09%3A25%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Functional%20correlations%20between%20CXCL10/IP10%20gene%20polymorphisms%20and%20risk%20of%20Kawasaki%20disease&rft.jtitle=Pediatric%20allergy%20and%20immunology&rft.au=Hsu,%20Yu%E2%80%90Wen&rft.date=2021-02&rft.volume=32&rft.issue=2&rft.spage=363&rft.epage=370&rft.pages=363-370&rft.issn=0905-6157&rft.eissn=1399-3038&rft_id=info:doi/10.1111/pai.13381&rft_dat=%3Cproquest_cross%3E2447308212%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2484171683&rft_id=info:pmid/32989803&rfr_iscdi=true |