A total weight loss of 25% shows better predictivity in evaluating the efficiency of bariatric surgery

Objectives The need for a unified definition of weight loss (WL) after bariatric surgery has recently been highlighted. We aimed to evaluate the reliability of two clinically common WL indications including percentage of total WL (%TWL) and percentage of excess WL (%EWL) through comparing their perf...

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Veröffentlicht in:International Journal of Obesity 2021-02, Vol.45 (2), p.396-403
Hauptverfasser: Tu, Yinfang, Pan, Yunhui, Han, Junfeng, Pan, Jiemin, Zhang, Pin, Jia, Weiping, Bao, Yuqian, Yu, Haoyong
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container_end_page 403
container_issue 2
container_start_page 396
container_title International Journal of Obesity
container_volume 45
creator Tu, Yinfang
Pan, Yunhui
Han, Junfeng
Pan, Jiemin
Zhang, Pin
Jia, Weiping
Bao, Yuqian
Yu, Haoyong
description Objectives The need for a unified definition of weight loss (WL) after bariatric surgery has recently been highlighted. We aimed to evaluate the reliability of two clinically common WL indications including percentage of total WL (%TWL) and percentage of excess WL (%EWL) through comparing their performances in predicting metabolic syndrome (MetS) remission 1 year after bariatric surgery. Methods A total of 430 individuals with obesity who underwent bariatric surgery were enrolled. Participants were evaluated for changes in anthropometric parameters, metabolic indexes, MetS components and medications before and 1 year after surgery. MetS was defined using the criteria of the National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans. Results The prevalence of MetS is 92.3% (397) at baseline. One year after bariatric surgery, 337 individuals (84.9%) were in MetS remission. The multivariate adjusted ORs were 1.16 (95% confidence interval [CI] 1.10–1.22) for each 1% increase in %TWL for MetS remission and 1.18 (95% CI 1.11–1.25) for each 5% increase in %EWL. This association with MetS remission remained statistically significant for %TWL after additional adjustment for %EWL ( P for trend 0.029), and disappeared for %EWL. Receiver operating curve (ROC) analyses showed that the %TWL was more predictive than the %EWL (AUC %TWL vs. AUC %EWL , 0.749 vs. 0.700, p  = 0.023). The Youden index indicated that the optimal %TWL cutoff point to identify MetS remission was 25%. Conclusions We recommend that good responders to bariatric surgery should be defined as those exhibiting %TWL ≥ 25%.
doi_str_mv 10.1038/s41366-020-00690-5
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We aimed to evaluate the reliability of two clinically common WL indications including percentage of total WL (%TWL) and percentage of excess WL (%EWL) through comparing their performances in predicting metabolic syndrome (MetS) remission 1 year after bariatric surgery. Methods A total of 430 individuals with obesity who underwent bariatric surgery were enrolled. Participants were evaluated for changes in anthropometric parameters, metabolic indexes, MetS components and medications before and 1 year after surgery. MetS was defined using the criteria of the National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans. Results The prevalence of MetS is 92.3% (397) at baseline. One year after bariatric surgery, 337 individuals (84.9%) were in MetS remission. The multivariate adjusted ORs were 1.16 (95% confidence interval [CI] 1.10–1.22) for each 1% increase in %TWL for MetS remission and 1.18 (95% CI 1.11–1.25) for each 5% increase in %EWL. This association with MetS remission remained statistically significant for %TWL after additional adjustment for %EWL ( P for trend 0.029), and disappeared for %EWL. Receiver operating curve (ROC) analyses showed that the %TWL was more predictive than the %EWL (AUC %TWL vs. AUC %EWL , 0.749 vs. 0.700, p  = 0.023). The Youden index indicated that the optimal %TWL cutoff point to identify MetS remission was 25%. Conclusions We recommend that good responders to bariatric surgery should be defined as those exhibiting %TWL ≥ 25%.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/s41366-020-00690-5</identifier><identifier>PMID: 32981929</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/163/2743 ; 692/699/2743/393 ; Adult ; Bariatric Surgery - statistics &amp; numerical data ; Body weight loss ; Care and treatment ; Cholesterol ; Confidence intervals ; Epidemiology ; Female ; Fish oils ; Gastrointestinal surgery ; Health Promotion and Disease Prevention ; Humans ; Internal Medicine ; Male ; Medicine ; Medicine &amp; Public Health ; Metabolic Diseases ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - complications ; Metabolic syndrome X ; Metabolism ; Middle Aged ; Obesity ; Obesity, Morbid - complications ; Obesity, Morbid - epidemiology ; Obesity, Morbid - surgery ; Performance prediction ; Prognosis ; Public Health ; Reliability analysis ; Remission ; Retrospective Studies ; Statistical analysis ; Statistics ; Surgery ; Treatment Outcome ; Weight loss ; Weight Loss - physiology</subject><ispartof>International Journal of Obesity, 2021-02, Vol.45 (2), p.396-403</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-e8d04b6189ddbe690bb3f71961c7ecdaa64142945c37c6b0205221a9a0b649773</citedby><cites>FETCH-LOGICAL-c539t-e8d04b6189ddbe690bb3f71961c7ecdaa64142945c37c6b0205221a9a0b649773</cites><orcidid>0000-0002-6244-2168 ; 0000-0002-1357-9539 ; 0000-0002-8621-4960 ; 0000-0003-1600-2716 ; 0000-0003-0474-1917 ; 0000-0001-6021-229X ; 0000-0001-8280-5213</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41366-020-00690-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41366-020-00690-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32981929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tu, Yinfang</creatorcontrib><creatorcontrib>Pan, Yunhui</creatorcontrib><creatorcontrib>Han, Junfeng</creatorcontrib><creatorcontrib>Pan, Jiemin</creatorcontrib><creatorcontrib>Zhang, Pin</creatorcontrib><creatorcontrib>Jia, Weiping</creatorcontrib><creatorcontrib>Bao, Yuqian</creatorcontrib><creatorcontrib>Yu, Haoyong</creatorcontrib><title>A total weight loss of 25% shows better predictivity in evaluating the efficiency of bariatric surgery</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Objectives The need for a unified definition of weight loss (WL) after bariatric surgery has recently been highlighted. We aimed to evaluate the reliability of two clinically common WL indications including percentage of total WL (%TWL) and percentage of excess WL (%EWL) through comparing their performances in predicting metabolic syndrome (MetS) remission 1 year after bariatric surgery. Methods A total of 430 individuals with obesity who underwent bariatric surgery were enrolled. Participants were evaluated for changes in anthropometric parameters, metabolic indexes, MetS components and medications before and 1 year after surgery. MetS was defined using the criteria of the National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans. Results The prevalence of MetS is 92.3% (397) at baseline. One year after bariatric surgery, 337 individuals (84.9%) were in MetS remission. The multivariate adjusted ORs were 1.16 (95% confidence interval [CI] 1.10–1.22) for each 1% increase in %TWL for MetS remission and 1.18 (95% CI 1.11–1.25) for each 5% increase in %EWL. This association with MetS remission remained statistically significant for %TWL after additional adjustment for %EWL ( P for trend 0.029), and disappeared for %EWL. Receiver operating curve (ROC) analyses showed that the %TWL was more predictive than the %EWL (AUC %TWL vs. AUC %EWL , 0.749 vs. 0.700, p  = 0.023). The Youden index indicated that the optimal %TWL cutoff point to identify MetS remission was 25%. 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We aimed to evaluate the reliability of two clinically common WL indications including percentage of total WL (%TWL) and percentage of excess WL (%EWL) through comparing their performances in predicting metabolic syndrome (MetS) remission 1 year after bariatric surgery. Methods A total of 430 individuals with obesity who underwent bariatric surgery were enrolled. Participants were evaluated for changes in anthropometric parameters, metabolic indexes, MetS components and medications before and 1 year after surgery. MetS was defined using the criteria of the National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans. Results The prevalence of MetS is 92.3% (397) at baseline. One year after bariatric surgery, 337 individuals (84.9%) were in MetS remission. The multivariate adjusted ORs were 1.16 (95% confidence interval [CI] 1.10–1.22) for each 1% increase in %TWL for MetS remission and 1.18 (95% CI 1.11–1.25) for each 5% increase in %EWL. This association with MetS remission remained statistically significant for %TWL after additional adjustment for %EWL ( P for trend 0.029), and disappeared for %EWL. Receiver operating curve (ROC) analyses showed that the %TWL was more predictive than the %EWL (AUC %TWL vs. AUC %EWL , 0.749 vs. 0.700, p  = 0.023). The Youden index indicated that the optimal %TWL cutoff point to identify MetS remission was 25%. Conclusions We recommend that good responders to bariatric surgery should be defined as those exhibiting %TWL ≥ 25%.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32981929</pmid><doi>10.1038/s41366-020-00690-5</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6244-2168</orcidid><orcidid>https://orcid.org/0000-0002-1357-9539</orcidid><orcidid>https://orcid.org/0000-0002-8621-4960</orcidid><orcidid>https://orcid.org/0000-0003-1600-2716</orcidid><orcidid>https://orcid.org/0000-0003-0474-1917</orcidid><orcidid>https://orcid.org/0000-0001-6021-229X</orcidid><orcidid>https://orcid.org/0000-0001-8280-5213</orcidid></addata></record>
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subjects 692/163/2743
692/699/2743/393
Adult
Bariatric Surgery - statistics & numerical data
Body weight loss
Care and treatment
Cholesterol
Confidence intervals
Epidemiology
Female
Fish oils
Gastrointestinal surgery
Health Promotion and Disease Prevention
Humans
Internal Medicine
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolic disorders
Metabolic syndrome
Metabolic Syndrome - complications
Metabolic syndrome X
Metabolism
Middle Aged
Obesity
Obesity, Morbid - complications
Obesity, Morbid - epidemiology
Obesity, Morbid - surgery
Performance prediction
Prognosis
Public Health
Reliability analysis
Remission
Retrospective Studies
Statistical analysis
Statistics
Surgery
Treatment Outcome
Weight loss
Weight Loss - physiology
title A total weight loss of 25% shows better predictivity in evaluating the efficiency of bariatric surgery
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