Antioxidant activity, phytochemical composition of Andricus tomentosus and its antiproliferative effect on Mia-Paca2 cell line
Plant derived products are widely used in cancer treatment. Gall species has been preferred for treatment various diseases in folk medicine, but there are few studies on the anticancer effects of gall species. The present study reports the antioxidant activity and total secondary metabolites of extr...
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| description | Plant derived products are widely used in cancer treatment. Gall species has been preferred for treatment various diseases in folk medicine, but there are few studies on the anticancer effects of gall species. The present study reports the antioxidant activity and total secondary metabolites of extracts of
A. tomentosus
galls. The antioxidant potency of galls was carried out using different
in-vitro
model systems. Their cytotoxic efficacy on Mia-Paca cell line was also explored. Gall extract was found to contain a large amount of phenolic acids. The extract potently scavenged free radicals including DPPH (IC
50
9.56 ± 1.08 µg/mL), ABTS (IC
50
18.51 ± 0.25 µg/mL). It can be seen as a potential source of antioxidants according to β-carotene/linoleic acid method (%92.58 ± 0.92) and Phosphomolybdenum assays (104.36 ± 4.95 mgAE/g). Gall extract also posses ability of metal chelating (%40.07 ± 2.30) and Fe
3+
(184.01 ± 2.83 mgTE/g) and Cu
2+
(89.81 ± 0.96 mgTE/g) reducing activity. According to total secondary metabolites tests, gall extract showed high total phenolic, total flavonoid and total tannin amount. HPLC analysis of the extract suggested it to contain caffeic acid (424.068.479 µg/g), ellagic acid (187.696.132 µg/g). XTT assay revealed gall extract to enhance percent survival of Mia-Paca2 cell line exposed
A. tomentosus
extracts. The best cytotoxic effect was determined in acetone extracts (IC
50
: 124.7 µM). Expression of some genes (
Bax, Bcl-2, FAS, BID, caspase-3, caspase-8, caspase-9, caspase-10, FADD, TRADD
) in the apoptosis pathway was determined to invastigate apoptosis inducing activity. These results indicate that
A. tomentosus
galls possess potent antioxidant activity, when tested both in chemical as well as biological models. |
| doi_str_mv | 10.1007/s11033-020-05833-5 |
| format | Article |
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A. tomentosus
galls. The antioxidant potency of galls was carried out using different
in-vitro
model systems. Their cytotoxic efficacy on Mia-Paca cell line was also explored. Gall extract was found to contain a large amount of phenolic acids. The extract potently scavenged free radicals including DPPH (IC
50
9.56 ± 1.08 µg/mL), ABTS (IC
50
18.51 ± 0.25 µg/mL). It can be seen as a potential source of antioxidants according to β-carotene/linoleic acid method (%92.58 ± 0.92) and Phosphomolybdenum assays (104.36 ± 4.95 mgAE/g). Gall extract also posses ability of metal chelating (%40.07 ± 2.30) and Fe
3+
(184.01 ± 2.83 mgTE/g) and Cu
2+
(89.81 ± 0.96 mgTE/g) reducing activity. According to total secondary metabolites tests, gall extract showed high total phenolic, total flavonoid and total tannin amount. HPLC analysis of the extract suggested it to contain caffeic acid (424.068.479 µg/g), ellagic acid (187.696.132 µg/g). XTT assay revealed gall extract to enhance percent survival of Mia-Paca2 cell line exposed
A. tomentosus
extracts. The best cytotoxic effect was determined in acetone extracts (IC
50
: 124.7 µM). Expression of some genes (
Bax, Bcl-2, FAS, BID, caspase-3, caspase-8, caspase-9, caspase-10, FADD, TRADD
) in the apoptosis pathway was determined to invastigate apoptosis inducing activity. These results indicate that
A. tomentosus
galls possess potent antioxidant activity, when tested both in chemical as well as biological models.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-020-05833-5</identifier><identifier>PMID: 32986201</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animal Anatomy ; Animal Biochemistry ; Animals ; Antioxidants ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Apoptosis ; Bcl-2 protein ; Biomedical and Life Sciences ; Caffeic acid ; Caspase-10 ; Caspase-3 ; Caspase-8 ; Caspase-9 ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell survival ; Copper ; Cytotoxicity ; Ellagic acid ; FADD protein ; Flavonoids ; Free radicals ; Galls ; High-performance liquid chromatography ; Histology ; Humans ; Iron ; Life Sciences ; Linoleic acid ; Metabolites ; Morphology ; Original Article ; Pancreatic Neoplasms - drug therapy ; Pancreatic Neoplasms - pathology ; Phenolic acids ; Phytochemicals - chemistry ; Phytochemicals - pharmacology ; Quercus - chemistry ; Secondary metabolites ; Wasps ; β-Carotene</subject><ispartof>Molecular biology reports, 2020-10, Vol.47 (10), p.7633-7641</ispartof><rights>Springer Nature B.V. 2020</rights><rights>Springer Nature B.V. 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2905-59f46e38a5a55a1d6c668c674ee508329e017f47634eb943995248e2a7faedcf3</citedby><cites>FETCH-LOGICAL-c2905-59f46e38a5a55a1d6c668c674ee508329e017f47634eb943995248e2a7faedcf3</cites><orcidid>0000-0003-4944-1029</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-020-05833-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-020-05833-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32986201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kılınçarslan Aksoy, Özge</creatorcontrib><creatorcontrib>Mammadov, Ramazan</creatorcontrib><creatorcontrib>Seçme, Mücahit</creatorcontrib><title>Antioxidant activity, phytochemical composition of Andricus tomentosus and its antiproliferative effect on Mia-Paca2 cell line</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Plant derived products are widely used in cancer treatment. Gall species has been preferred for treatment various diseases in folk medicine, but there are few studies on the anticancer effects of gall species. The present study reports the antioxidant activity and total secondary metabolites of extracts of
A. tomentosus
galls. The antioxidant potency of galls was carried out using different
in-vitro
model systems. Their cytotoxic efficacy on Mia-Paca cell line was also explored. Gall extract was found to contain a large amount of phenolic acids. The extract potently scavenged free radicals including DPPH (IC
50
9.56 ± 1.08 µg/mL), ABTS (IC
50
18.51 ± 0.25 µg/mL). It can be seen as a potential source of antioxidants according to β-carotene/linoleic acid method (%92.58 ± 0.92) and Phosphomolybdenum assays (104.36 ± 4.95 mgAE/g). Gall extract also posses ability of metal chelating (%40.07 ± 2.30) and Fe
3+
(184.01 ± 2.83 mgTE/g) and Cu
2+
(89.81 ± 0.96 mgTE/g) reducing activity. According to total secondary metabolites tests, gall extract showed high total phenolic, total flavonoid and total tannin amount. HPLC analysis of the extract suggested it to contain caffeic acid (424.068.479 µg/g), ellagic acid (187.696.132 µg/g). XTT assay revealed gall extract to enhance percent survival of Mia-Paca2 cell line exposed
A. tomentosus
extracts. The best cytotoxic effect was determined in acetone extracts (IC
50
: 124.7 µM). Expression of some genes (
Bax, Bcl-2, FAS, BID, caspase-3, caspase-8, caspase-9, caspase-10, FADD, TRADD
) in the apoptosis pathway was determined to invastigate apoptosis inducing activity. These results indicate that
A. tomentosus
galls possess potent antioxidant activity, when tested both in chemical as well as biological models.</description><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>Apoptosis</subject><subject>Bcl-2 protein</subject><subject>Biomedical and Life Sciences</subject><subject>Caffeic acid</subject><subject>Caspase-10</subject><subject>Caspase-3</subject><subject>Caspase-8</subject><subject>Caspase-9</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell survival</subject><subject>Copper</subject><subject>Cytotoxicity</subject><subject>Ellagic acid</subject><subject>FADD protein</subject><subject>Flavonoids</subject><subject>Free radicals</subject><subject>Galls</subject><subject>High-performance liquid chromatography</subject><subject>Histology</subject><subject>Humans</subject><subject>Iron</subject><subject>Life Sciences</subject><subject>Linoleic acid</subject><subject>Metabolites</subject><subject>Morphology</subject><subject>Original Article</subject><subject>Pancreatic Neoplasms - drug therapy</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Phenolic acids</subject><subject>Phytochemicals - chemistry</subject><subject>Phytochemicals - pharmacology</subject><subject>Quercus - chemistry</subject><subject>Secondary metabolites</subject><subject>Wasps</subject><subject>β-Carotene</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU9vFSEUxYnR2Gf1C7gwJG66cJS_AyxfGqsmbXSha0KZi6WZgScwxrfxs5fnq5q4cHVvwu8cDhyEnlPymhKi3lRKCecDYWQgUvdNPkAbKhUfhFH6IdoQTuggtKQn6Emtt4QQQZV8jE44M3pkhG7Qz21qMf-Ik0sNO9_i99j2r_DuZt-yv4Elejdjn5ddrrGDCeeAt2kq0a8Vt7xAarn21aUJx3aYLe5KnmOA4robYAgBfMNdehXd8Ml5x7CHecZzTPAUPQpurvDsfp6iLxdvP5-_Hy4_vvtwvr0cPDNEDtIEMQLXTjopHZ1GP47aj0oASKL7a4BQFYQauYBrI7gxkgkNzKngYPKBn6Kzo2_P9m2F2uwS6yGFS5DXapkQo9FaCdPRl_-gt3ktqaezTCqlhOif2Cl2pHzJtRYIdlfi4sreUmIP7dhjO7a3Y3-1Y2UXvbi3Xq8XmP5IftfRAX4Eaj9KX6H8vfs_tnfY8Jtm</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Kılınçarslan Aksoy, Özge</creator><creator>Mammadov, Ramazan</creator><creator>Seçme, Mücahit</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4944-1029</orcidid></search><sort><creationdate>20201001</creationdate><title>Antioxidant activity, phytochemical composition of Andricus tomentosus and its antiproliferative effect on Mia-Paca2 cell line</title><author>Kılınçarslan Aksoy, Özge ; Mammadov, Ramazan ; Seçme, Mücahit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2905-59f46e38a5a55a1d6c668c674ee508329e017f47634eb943995248e2a7faedcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - pharmacology</topic><topic>Apoptosis</topic><topic>Bcl-2 protein</topic><topic>Biomedical and Life Sciences</topic><topic>Caffeic acid</topic><topic>Caspase-10</topic><topic>Caspase-3</topic><topic>Caspase-8</topic><topic>Caspase-9</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell survival</topic><topic>Copper</topic><topic>Cytotoxicity</topic><topic>Ellagic acid</topic><topic>FADD protein</topic><topic>Flavonoids</topic><topic>Free radicals</topic><topic>Galls</topic><topic>High-performance liquid chromatography</topic><topic>Histology</topic><topic>Humans</topic><topic>Iron</topic><topic>Life Sciences</topic><topic>Linoleic acid</topic><topic>Metabolites</topic><topic>Morphology</topic><topic>Original Article</topic><topic>Pancreatic Neoplasms - drug therapy</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Phenolic acids</topic><topic>Phytochemicals - chemistry</topic><topic>Phytochemicals - pharmacology</topic><topic>Quercus - chemistry</topic><topic>Secondary metabolites</topic><topic>Wasps</topic><topic>β-Carotene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kılınçarslan Aksoy, Özge</creatorcontrib><creatorcontrib>Mammadov, Ramazan</creatorcontrib><creatorcontrib>Seçme, Mücahit</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kılınçarslan Aksoy, Özge</au><au>Mammadov, Ramazan</au><au>Seçme, Mücahit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant activity, phytochemical composition of Andricus tomentosus and its antiproliferative effect on Mia-Paca2 cell line</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>47</volume><issue>10</issue><spage>7633</spage><epage>7641</epage><pages>7633-7641</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>Plant derived products are widely used in cancer treatment. Gall species has been preferred for treatment various diseases in folk medicine, but there are few studies on the anticancer effects of gall species. The present study reports the antioxidant activity and total secondary metabolites of extracts of
A. tomentosus
galls. The antioxidant potency of galls was carried out using different
in-vitro
model systems. Their cytotoxic efficacy on Mia-Paca cell line was also explored. Gall extract was found to contain a large amount of phenolic acids. The extract potently scavenged free radicals including DPPH (IC
50
9.56 ± 1.08 µg/mL), ABTS (IC
50
18.51 ± 0.25 µg/mL). It can be seen as a potential source of antioxidants according to β-carotene/linoleic acid method (%92.58 ± 0.92) and Phosphomolybdenum assays (104.36 ± 4.95 mgAE/g). Gall extract also posses ability of metal chelating (%40.07 ± 2.30) and Fe
3+
(184.01 ± 2.83 mgTE/g) and Cu
2+
(89.81 ± 0.96 mgTE/g) reducing activity. According to total secondary metabolites tests, gall extract showed high total phenolic, total flavonoid and total tannin amount. HPLC analysis of the extract suggested it to contain caffeic acid (424.068.479 µg/g), ellagic acid (187.696.132 µg/g). XTT assay revealed gall extract to enhance percent survival of Mia-Paca2 cell line exposed
A. tomentosus
extracts. The best cytotoxic effect was determined in acetone extracts (IC
50
: 124.7 µM). Expression of some genes (
Bax, Bcl-2, FAS, BID, caspase-3, caspase-8, caspase-9, caspase-10, FADD, TRADD
) in the apoptosis pathway was determined to invastigate apoptosis inducing activity. These results indicate that
A. tomentosus
galls possess potent antioxidant activity, when tested both in chemical as well as biological models.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>32986201</pmid><doi>10.1007/s11033-020-05833-5</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4944-1029</orcidid></addata></record> |
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| subjects | Animal Anatomy Animal Biochemistry Animals Antioxidants Antioxidants - chemistry Antioxidants - pharmacology Apoptosis Bcl-2 protein Biomedical and Life Sciences Caffeic acid Caspase-10 Caspase-3 Caspase-8 Caspase-9 Cell Line, Tumor Cell Proliferation - drug effects Cell survival Copper Cytotoxicity Ellagic acid FADD protein Flavonoids Free radicals Galls High-performance liquid chromatography Histology Humans Iron Life Sciences Linoleic acid Metabolites Morphology Original Article Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Phenolic acids Phytochemicals - chemistry Phytochemicals - pharmacology Quercus - chemistry Secondary metabolites Wasps β-Carotene |
| title | Antioxidant activity, phytochemical composition of Andricus tomentosus and its antiproliferative effect on Mia-Paca2 cell line |
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