Tyrosine‐derived polycarbonate nerve guidance tubes elicit proregenerative extracellular matrix deposition when used to bridge segmental nerve defects in swine

Promising biomaterials should be tested in appropriate large animal models that recapitulate human inflammatory and regenerative responses. Previous studies have shown tyrosine‐derived polycarbonates (TyrPC) are versatile biomaterials with a wide range of applications across multiple disciplines. Th...

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Veröffentlicht in:	Journal of biomedical materials research. Part A 2021-07, Vol.109 (7), p.1183-1195
Hauptverfasser:	Burrell, Justin C., Bhatnagar, Divya, Brown, Dan P., Murthy, N. Sanjeeva, Dutton, John, Browne, Kevin D., Laimo, Franco A., Ali, Zarina S., Rosen, Joseph M., Kaplan, Hilton M., Kohn, Joachim, Cullen, D. Kacy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals autograft Biomaterials Biomedical materials Collagen Collagen (type I) Collagen (type III) Collagen (type IV) Composition Defects Deposition Electrophysiology Extracellular matrix Extracellular Matrix - metabolism extracellular matrix protein deposition Fibronectin Guided Tissue Regeneration - methods Infiltration Inflammation Laminin large animal Mechanical properties Morphometry Muscles nerve guidance tube Nerve Regeneration Peripheral Nerve Injuries - therapy peripheral nerve injury Peripheral nerves Peroneal Nerve - injuries Peroneal Nerve - metabolism Peroneal Nerve - physiology Polycarbonate Polycarbonate resins Polycarboxylate Cement - chemistry Polymers Recovery of function Regeneration Repair Schwann Cells - cytology Schwann Cells - metabolism Swine Tissue Scaffolds - chemistry Tubes Tyrosine Tyrosine - chemistry tyrosine‐derived polycarbonate
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