TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury

The role and underlying mechanism of plasma membrane‐bound G protein‐coupled bile acid receptor (TGR5) in regulating macrophage innate immune activation during liver ischemia and reperfusion (IR) injury remains largely unclear. Here, we demonstrated that TGR5 depletion in myeloid cells aggravated li...

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Veröffentlicht in:	American journal of transplantation 2021-04, Vol.21 (4), p.1453-1464
Hauptverfasser:	Zhou, Haoming, Zhou, Shun, Shi, Yong, Wang, Qi, Wei, Song, Wang, Ping, Cheng, Feng, Auwerx, Johan, Schoonjans, Kristina, Lu, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Cathepsin E CD11b antigen Cell activation DNA microarrays Electrophoretic mobility Hepatectomy Hepatocytes Humans Immune response Immunity, Innate Inflammation Ischemia Leukocyte migration Leukocytes, Mononuclear Liver Macrophage Activation Macrophages Membrane proteins Mice Mice, Inbred C57BL Myeloid cells Peripheral blood mononuclear cells Phenotypes Polarization Receptors, G-Protein-Coupled Reperfusion Reperfusion Injury Ursodeoxycholic acid
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