Improving the biotransformation of phytosterols to 9α-hydroxy-4-androstene-3,17-dione by deleting embC associated with the assembly of cell envelope in Mycobacterium neoaurum

•The embC involved in the lipoarabinomannan synthesis in M. neoaurum was located.•The assembly defect of lipoarabinomannan enhanced cell permeability and steroid uptake.•The deficiency of embC improved the bioconversion of sterols to 9-OHAD. The conversion of low value-added phytosterols into 9α-hyd...

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Veröffentlicht in:	Journal of biotechnology 2020-11, Vol.323, p.341-346
Hauptverfasser:	Xiong, Liang-Bin, Liu, Hao-Hao, Song, Xin-Wei, Meng, Xiang-Guo, Liu, Xian-Zhou, Ji, Yu-Qing, Wang, Feng-Qing, Wei, Dong-Zhi
Format:	Artikel
Sprache:	eng
Schlagworte:	9-OHAD Cell envelope engineering EmbC Lipoarabinomannan Sterol
Online-Zugang:	Volltext
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