Comparative study of microvascular function: Forearm blood flow versus dynamic retinal vessel analysis
Objective Recently, dynamic retinal vessel analysis (DVA) has gained interest for investigation of microvascular function but comparative measurements with standard methods like the forearm blood flow technique (FBF) are uncommon till now. Methods We recruited 23 high‐risk cardiovascular patients (R...
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| Veröffentlicht in: | Clinical physiology and functional imaging 2021-01, Vol.41 (1), p.42-50 |
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| creator | Schirutschke, Holger Kochan, Johannes Haink, Kristin Rettig, Ronny Parmentier, Simon Paul Ziemssen, Tjalf Passauer, Jens |
| description | Objective
Recently, dynamic retinal vessel analysis (DVA) has gained interest for investigation of microvascular function but comparative measurements with standard methods like the forearm blood flow technique (FBF) are uncommon till now.
Methods
We recruited 23 high‐risk cardiovascular patients (Risk) and 17 healthy persons (Ctrl). During the FBF experiment, postocclusive reactive hyperaemia (RH) as well as endothelium‐dependent and independent vasodilation was measured by infusion of acetylcholine (ACh) and sodium nitroprusside (SNP) into the brachial artery. The dynamic vessel analyzer was applied for measurement of the retinal arterial and venous response to flickering light during DVA and for determination of the central retinal arterial (CRAE) and venous equivalent (CRVE).
Results
Forearm blood flow technique was significantly attenuated in the patient group during postocclusive RH (p |
| doi_str_mv | 10.1111/cpf.12664 |
| format | Article |
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Recently, dynamic retinal vessel analysis (DVA) has gained interest for investigation of microvascular function but comparative measurements with standard methods like the forearm blood flow technique (FBF) are uncommon till now.
Methods
We recruited 23 high‐risk cardiovascular patients (Risk) and 17 healthy persons (Ctrl). During the FBF experiment, postocclusive reactive hyperaemia (RH) as well as endothelium‐dependent and independent vasodilation was measured by infusion of acetylcholine (ACh) and sodium nitroprusside (SNP) into the brachial artery. The dynamic vessel analyzer was applied for measurement of the retinal arterial and venous response to flickering light during DVA and for determination of the central retinal arterial (CRAE) and venous equivalent (CRVE).
Results
Forearm blood flow technique was significantly attenuated in the patient group during postocclusive RH (p < .005). The increase of FBF in response to SNP did not differ significantly between the two groups (p = .09). In contrast, the FBF response to ACh was significantly blunted in the patient group (p < .05), indicating endothelial dysfunction. DVA did not detect any difference of retinal arterial (p = .68) or retinal venous (p = .93) vasodilation between both groups. The CRAE (p = .55) and CRVE (p = .83) did not differ significantly in either group.
Conclusions
Forearm blood flow and DVA cannot be regarded as equivalent methods for testing of microvascular function. Possible explanations include differences in the vascular beds and vessel diameters examined as well as differences in the trigger mechanisms applied. Further studies are needed to define the role of DVA in this context.</description><identifier>ISSN: 1475-0961</identifier><identifier>EISSN: 1475-097X</identifier><identifier>DOI: 10.1111/cpf.12664</identifier><identifier>PMID: 32978862</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Acetylcholine ; Blood flow ; Blood vessels ; Cardiovascular diseases ; central retinal arterial equivalent ; central retinal venous equivalent ; Comparative studies ; Diameters ; endothelial function ; Endothelium ; Equivalence ; Forearm ; Hyperemia ; Light effects ; microcirculation ; Microvasculature ; nitric oxide ; postocclusive reactive hyperaemia ; Retina ; retinal vascular function imaging ; Sodium nitroprusside ; Vasodilation ; venous occlusion plethysmography</subject><ispartof>Clinical physiology and functional imaging, 2021-01, Vol.41 (1), p.42-50</ispartof><rights>2020 The Authors. published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine</rights><rights>2020 The Authors. Clinical Physiology and Functional Imaging published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3884-5966a7a8a06c1674ab38887fc23fe1d0867b1cebd8bd417dcd64fcfd0e8cc4b43</citedby><cites>FETCH-LOGICAL-c3884-5966a7a8a06c1674ab38887fc23fe1d0867b1cebd8bd417dcd64fcfd0e8cc4b43</cites><orcidid>0000-0002-0774-5553</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcpf.12664$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcpf.12664$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32978862$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schirutschke, Holger</creatorcontrib><creatorcontrib>Kochan, Johannes</creatorcontrib><creatorcontrib>Haink, Kristin</creatorcontrib><creatorcontrib>Rettig, Ronny</creatorcontrib><creatorcontrib>Parmentier, Simon Paul</creatorcontrib><creatorcontrib>Ziemssen, Tjalf</creatorcontrib><creatorcontrib>Passauer, Jens</creatorcontrib><title>Comparative study of microvascular function: Forearm blood flow versus dynamic retinal vessel analysis</title><title>Clinical physiology and functional imaging</title><addtitle>Clin Physiol Funct Imaging</addtitle><description>Objective
Recently, dynamic retinal vessel analysis (DVA) has gained interest for investigation of microvascular function but comparative measurements with standard methods like the forearm blood flow technique (FBF) are uncommon till now.
Methods
We recruited 23 high‐risk cardiovascular patients (Risk) and 17 healthy persons (Ctrl). During the FBF experiment, postocclusive reactive hyperaemia (RH) as well as endothelium‐dependent and independent vasodilation was measured by infusion of acetylcholine (ACh) and sodium nitroprusside (SNP) into the brachial artery. The dynamic vessel analyzer was applied for measurement of the retinal arterial and venous response to flickering light during DVA and for determination of the central retinal arterial (CRAE) and venous equivalent (CRVE).
Results
Forearm blood flow technique was significantly attenuated in the patient group during postocclusive RH (p < .005). The increase of FBF in response to SNP did not differ significantly between the two groups (p = .09). In contrast, the FBF response to ACh was significantly blunted in the patient group (p < .05), indicating endothelial dysfunction. DVA did not detect any difference of retinal arterial (p = .68) or retinal venous (p = .93) vasodilation between both groups. The CRAE (p = .55) and CRVE (p = .83) did not differ significantly in either group.
Conclusions
Forearm blood flow and DVA cannot be regarded as equivalent methods for testing of microvascular function. Possible explanations include differences in the vascular beds and vessel diameters examined as well as differences in the trigger mechanisms applied. Further studies are needed to define the role of DVA in this context.</description><subject>Acetylcholine</subject><subject>Blood flow</subject><subject>Blood vessels</subject><subject>Cardiovascular diseases</subject><subject>central retinal arterial equivalent</subject><subject>central retinal venous equivalent</subject><subject>Comparative studies</subject><subject>Diameters</subject><subject>endothelial function</subject><subject>Endothelium</subject><subject>Equivalence</subject><subject>Forearm</subject><subject>Hyperemia</subject><subject>Light effects</subject><subject>microcirculation</subject><subject>Microvasculature</subject><subject>nitric oxide</subject><subject>postocclusive reactive hyperaemia</subject><subject>Retina</subject><subject>retinal vascular function imaging</subject><subject>Sodium nitroprusside</subject><subject>Vasodilation</subject><subject>venous occlusion plethysmography</subject><issn>1475-0961</issn><issn>1475-097X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp1kM9LwzAUx4Mobk4P_gMS8KKHbkmbJak3GU6FgR4UvJU0P6AjbWrSbvS_N3PTg-C7vMfj8748PgBcYjTFsWayNVOcUkqOwBgTNk9Qzj6Of2eKR-AshDVCmGWEnYJRluaMc5qOgVm4uhVedNVGw9D1aoDOwLqS3m1EkL0VHpq-kV3lmju4dF4LX8PSOqegsW4LN9qHPkA1NCJeQa-7qhE2rkPQFoo4D6EK5-DECBv0xaFPwPvy4W3xlKxeHp8X96tEZpyTZJ5TKpjgAlGJKSOijGvOjEwzo7FCnLISS10qXiqCmZKKEiONQppLSUqSTcDNPrf17rPXoSvqKkhtrWi060OREkIpwwTRiF7_Qdeu9_HfHUXzOc1Tlkfqdk9FISF4bYrWV7XwQ4FRsZNfRPnFt_zIXh0S-7LW6pf8sR2B2R7YVlYP_ycVi9flPvILP8SQEQ</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Schirutschke, Holger</creator><creator>Kochan, Johannes</creator><creator>Haink, Kristin</creator><creator>Rettig, Ronny</creator><creator>Parmentier, Simon Paul</creator><creator>Ziemssen, Tjalf</creator><creator>Passauer, Jens</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TS</scope><scope>7U5</scope><scope>8FD</scope><scope>K9.</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0774-5553</orcidid></search><sort><creationdate>202101</creationdate><title>Comparative study of microvascular function: Forearm blood flow versus dynamic retinal vessel analysis</title><author>Schirutschke, Holger ; Kochan, Johannes ; Haink, Kristin ; Rettig, Ronny ; Parmentier, Simon Paul ; Ziemssen, Tjalf ; Passauer, Jens</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3884-5966a7a8a06c1674ab38887fc23fe1d0867b1cebd8bd417dcd64fcfd0e8cc4b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acetylcholine</topic><topic>Blood flow</topic><topic>Blood vessels</topic><topic>Cardiovascular diseases</topic><topic>central retinal arterial equivalent</topic><topic>central retinal venous equivalent</topic><topic>Comparative studies</topic><topic>Diameters</topic><topic>endothelial function</topic><topic>Endothelium</topic><topic>Equivalence</topic><topic>Forearm</topic><topic>Hyperemia</topic><topic>Light effects</topic><topic>microcirculation</topic><topic>Microvasculature</topic><topic>nitric oxide</topic><topic>postocclusive reactive hyperaemia</topic><topic>Retina</topic><topic>retinal vascular function imaging</topic><topic>Sodium nitroprusside</topic><topic>Vasodilation</topic><topic>venous occlusion plethysmography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schirutschke, Holger</creatorcontrib><creatorcontrib>Kochan, Johannes</creatorcontrib><creatorcontrib>Haink, Kristin</creatorcontrib><creatorcontrib>Rettig, Ronny</creatorcontrib><creatorcontrib>Parmentier, Simon Paul</creatorcontrib><creatorcontrib>Ziemssen, Tjalf</creatorcontrib><creatorcontrib>Passauer, Jens</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical physiology and functional imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schirutschke, Holger</au><au>Kochan, Johannes</au><au>Haink, Kristin</au><au>Rettig, Ronny</au><au>Parmentier, Simon Paul</au><au>Ziemssen, Tjalf</au><au>Passauer, Jens</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative study of microvascular function: Forearm blood flow versus dynamic retinal vessel analysis</atitle><jtitle>Clinical physiology and functional imaging</jtitle><addtitle>Clin Physiol Funct Imaging</addtitle><date>2021-01</date><risdate>2021</risdate><volume>41</volume><issue>1</issue><spage>42</spage><epage>50</epage><pages>42-50</pages><issn>1475-0961</issn><eissn>1475-097X</eissn><abstract>Objective
Recently, dynamic retinal vessel analysis (DVA) has gained interest for investigation of microvascular function but comparative measurements with standard methods like the forearm blood flow technique (FBF) are uncommon till now.
Methods
We recruited 23 high‐risk cardiovascular patients (Risk) and 17 healthy persons (Ctrl). During the FBF experiment, postocclusive reactive hyperaemia (RH) as well as endothelium‐dependent and independent vasodilation was measured by infusion of acetylcholine (ACh) and sodium nitroprusside (SNP) into the brachial artery. The dynamic vessel analyzer was applied for measurement of the retinal arterial and venous response to flickering light during DVA and for determination of the central retinal arterial (CRAE) and venous equivalent (CRVE).
Results
Forearm blood flow technique was significantly attenuated in the patient group during postocclusive RH (p < .005). The increase of FBF in response to SNP did not differ significantly between the two groups (p = .09). In contrast, the FBF response to ACh was significantly blunted in the patient group (p < .05), indicating endothelial dysfunction. DVA did not detect any difference of retinal arterial (p = .68) or retinal venous (p = .93) vasodilation between both groups. The CRAE (p = .55) and CRVE (p = .83) did not differ significantly in either group.
Conclusions
Forearm blood flow and DVA cannot be regarded as equivalent methods for testing of microvascular function. Possible explanations include differences in the vascular beds and vessel diameters examined as well as differences in the trigger mechanisms applied. Further studies are needed to define the role of DVA in this context.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32978862</pmid><doi>10.1111/cpf.12664</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0774-5553</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acetylcholine Blood flow Blood vessels Cardiovascular diseases central retinal arterial equivalent central retinal venous equivalent Comparative studies Diameters endothelial function Endothelium Equivalence Forearm Hyperemia Light effects microcirculation Microvasculature nitric oxide postocclusive reactive hyperaemia Retina retinal vascular function imaging Sodium nitroprusside Vasodilation venous occlusion plethysmography |
| title | Comparative study of microvascular function: Forearm blood flow versus dynamic retinal vessel analysis |
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