Biochemistry of mammalian ferritins in the regulation of cellular iron homeostasis and oxidative responses

Ferritin, an iron-storage protein, regulates cellular iron metabolism and oxidative stress. The ferritin structure is characterized as a spherical cage, inside which large amounts of iron are deposited in a safe, compact and bioavailable form. All ferritins readily catalyze Fe(II) oxidation by perox...

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Veröffentlicht in:	Science China. Life sciences 2021-03, Vol.64 (3), p.352-362
Hauptverfasser:	Zhang, Jianlin, Chen, Xuehui, Hong, Juanji, Tang, Aifa, Liu, Yang, Xie, Ni, Nie, Guohui, Yan, Xiyun, Liang, Minmin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Ferritin Ferritins - chemistry Ferritins - genetics Ferritins - metabolism Ferroxidase Heme Homeostasis Humans Intracellular Iron Life Sciences Lysosomes Mitochondria Oxidation Oxidative metabolism Oxidative Stress Post-transcription Protein turnover Reactive oxygen species Review
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