Bioavailability Enhancement and Food Effect Elimination of Abiraterone Acetate by Encapsulation in Surfactant-Enriched Oil Marbles

Abiraterone acetate has limited bioavailability in the fasted state and exhibits a strong positive food effect. We present a novel formulation concept based on the so-called oil marbles (OMs) and show by in vitro and in vivo experiments that the food effect can be suppressed. OMs are spherical parti...

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Veröffentlicht in:	The AAPS journal 2020-09, Vol.22 (6), p.122-122, Article 122
Hauptverfasser:	Boleslavská, Tereza, Rychecký, Ondřej, Krov, Martin, Žvátora, Pavel, Dammer, Ondřej, Beránek, Josef, Kozlík, Petr, Křížek, Tomáš, Hořínková, Jana, Ryšánek, Pavel, Roušarová, Jaroslava, Canová, Nikolina Kutinová, Šíma, Martin, Slanař, Ondřej, Štěpánek, František
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Pharmacology/Toxicology Pharmacy Research Article
Online-Zugang:	Volltext
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