Interleukin 17 receptor A haplotype analysis in chronic spontaneous urticaria: A preliminary study
Background Chronic spontaneous urticaria (CSU) is a distressing skin disease. Family clustering and heterogeneity in the onset and progression indicate that susceptibility to CSU is a complex trait. In this study, we performed haplotype analysis for one of the key player gene, IL17RA, for CSU to tes...
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| Veröffentlicht in: | Journal of cosmetic dermatology 2021-04, Vol.20 (4), p.1331-1342 |
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| container_title | Journal of cosmetic dermatology |
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| creator | Nada, Hesham Hassan, Ranya Ibrahim, Rasha Abd El‐Hamed Abdelsalam, Omnia Emad Fathy, Amal Toraih, Eman Ali Atwa, Mona A. |
| description | Background
Chronic spontaneous urticaria (CSU) is a distressing skin disease. Family clustering and heterogeneity in the onset and progression indicate that susceptibility to CSU is a complex trait. In this study, we performed haplotype analysis for one of the key player gene, IL17RA, for CSU to test the association with disease susceptibility and severity.
Methodology
The study included 70 CSU patients and 30 healthy controls. The severity of the disease was evaluated by autologous serum skin test (ASST) and urticaria activity score (UAS). ASST test was done and quality of life was assessed using a questionnaire. Allelic discrimination analysis for rs4819554 and rs879577 was performed using real‐time polymerase chain reaction technology.
Results
Carriers of rs4819554*G were more prone to develop CSU than its counterpart (P = .039), while rs4819554*A allele displayed more severe phenotype in the form of more prolonged disease duration (P = .040), concurrent angioedema (P |
| doi_str_mv | 10.1111/jocd.13730 |
| format | Article |
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Chronic spontaneous urticaria (CSU) is a distressing skin disease. Family clustering and heterogeneity in the onset and progression indicate that susceptibility to CSU is a complex trait. In this study, we performed haplotype analysis for one of the key player gene, IL17RA, for CSU to test the association with disease susceptibility and severity.
Methodology
The study included 70 CSU patients and 30 healthy controls. The severity of the disease was evaluated by autologous serum skin test (ASST) and urticaria activity score (UAS). ASST test was done and quality of life was assessed using a questionnaire. Allelic discrimination analysis for rs4819554 and rs879577 was performed using real‐time polymerase chain reaction technology.
Results
Carriers of rs4819554*G were more prone to develop CSU than its counterpart (P = .039), while rs4819554*A allele displayed more severe phenotype in the form of more prolonged disease duration (P = .040), concurrent angioedema (P < .001), higher level of treatment (P < .001), and higher score of quality of life (P < .001). Additionally, homozygote patients with rs879577*CC were associated with angioedema (P < .001). Haplotype analysis revealed that cohorts with both rs4819554*A and rs879577*T conferred protection against developing CSU (OR = 0.07, 95% CI = 0.01‐0.32, P = .001).
Conclusion
Our results showed that IL17RA gene polymorphisms might contribute to the increased susceptibility to CSU.</description><identifier>ISSN: 1473-2130</identifier><identifier>EISSN: 1473-2165</identifier><identifier>DOI: 10.1111/jocd.13730</identifier><identifier>PMID: 32969586</identifier><language>eng</language><publisher>England</publisher><subject>Chronic Disease ; chronic spontaneous urticaria ; Chronic Urticaria - genetics ; haplotype ; Haplotypes ; Humans ; IL‐17RA ; Quality of Life ; Receptors, Interleukin-17 ; variant</subject><ispartof>Journal of cosmetic dermatology, 2021-04, Vol.20 (4), p.1331-1342</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3950-729ba1c7b0b3a275acac169a3969e4263cd2b9eed3f492369f450cb8a05c5aa03</citedby><cites>FETCH-LOGICAL-c3950-729ba1c7b0b3a275acac169a3969e4263cd2b9eed3f492369f450cb8a05c5aa03</cites><orcidid>0000-0001-9267-3787</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjocd.13730$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjocd.13730$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32969586$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nada, Hesham</creatorcontrib><creatorcontrib>Hassan, Ranya</creatorcontrib><creatorcontrib>Ibrahim, Rasha Abd El‐Hamed</creatorcontrib><creatorcontrib>Abdelsalam, Omnia Emad</creatorcontrib><creatorcontrib>Fathy, Amal</creatorcontrib><creatorcontrib>Toraih, Eman Ali</creatorcontrib><creatorcontrib>Atwa, Mona A.</creatorcontrib><title>Interleukin 17 receptor A haplotype analysis in chronic spontaneous urticaria: A preliminary study</title><title>Journal of cosmetic dermatology</title><addtitle>J Cosmet Dermatol</addtitle><description>Background
Chronic spontaneous urticaria (CSU) is a distressing skin disease. Family clustering and heterogeneity in the onset and progression indicate that susceptibility to CSU is a complex trait. In this study, we performed haplotype analysis for one of the key player gene, IL17RA, for CSU to test the association with disease susceptibility and severity.
Methodology
The study included 70 CSU patients and 30 healthy controls. The severity of the disease was evaluated by autologous serum skin test (ASST) and urticaria activity score (UAS). ASST test was done and quality of life was assessed using a questionnaire. Allelic discrimination analysis for rs4819554 and rs879577 was performed using real‐time polymerase chain reaction technology.
Results
Carriers of rs4819554*G were more prone to develop CSU than its counterpart (P = .039), while rs4819554*A allele displayed more severe phenotype in the form of more prolonged disease duration (P = .040), concurrent angioedema (P < .001), higher level of treatment (P < .001), and higher score of quality of life (P < .001). Additionally, homozygote patients with rs879577*CC were associated with angioedema (P < .001). Haplotype analysis revealed that cohorts with both rs4819554*A and rs879577*T conferred protection against developing CSU (OR = 0.07, 95% CI = 0.01‐0.32, P = .001).
Conclusion
Our results showed that IL17RA gene polymorphisms might contribute to the increased susceptibility to CSU.</description><subject>Chronic Disease</subject><subject>chronic spontaneous urticaria</subject><subject>Chronic Urticaria - genetics</subject><subject>haplotype</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>IL‐17RA</subject><subject>Quality of Life</subject><subject>Receptors, Interleukin-17</subject><subject>variant</subject><issn>1473-2130</issn><issn>1473-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqWw8AOQR4SUYsdxErNV5auoUheYI8e5qC5OHOxEKP-elJSO3HI3PPfq1YPQNSVzOsz9zqpiTlnCyAma0ihhQUhjfnq8GZmgC-93hNBEUH6OJiwUseBpPEX5qm7BGeg-dY1pgh0oaFrr8AJvZWNs2zeAZS1N77XHA6O2ztZaYd_YupU12M7jzrVaSaflw_DWODC60rV0PfZtV_SX6KyUxsPVYc_Qx_PT-_I1WG9eVsvFOlBMcBIkocglVUlOcibDhEslFY2FZENViMKYqSLMBUDBykiELBZlxInKU0m44lISNkO3Y27j7FcHvs0q7RUYM7bMwijiIiEpSQf0bkSVs947KLPG6WponFGS7Z1me6fZr9MBvjnkdnkFxRH9kzgAdAS-tYH-n6jsbbN8HEN_AJrYgqU</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Nada, Hesham</creator><creator>Hassan, Ranya</creator><creator>Ibrahim, Rasha Abd El‐Hamed</creator><creator>Abdelsalam, Omnia Emad</creator><creator>Fathy, Amal</creator><creator>Toraih, Eman Ali</creator><creator>Atwa, Mona A.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9267-3787</orcidid></search><sort><creationdate>202104</creationdate><title>Interleukin 17 receptor A haplotype analysis in chronic spontaneous urticaria: A preliminary study</title><author>Nada, Hesham ; Hassan, Ranya ; Ibrahim, Rasha Abd El‐Hamed ; Abdelsalam, Omnia Emad ; Fathy, Amal ; Toraih, Eman Ali ; Atwa, Mona A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3950-729ba1c7b0b3a275acac169a3969e4263cd2b9eed3f492369f450cb8a05c5aa03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Chronic Disease</topic><topic>chronic spontaneous urticaria</topic><topic>Chronic Urticaria - genetics</topic><topic>haplotype</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>IL‐17RA</topic><topic>Quality of Life</topic><topic>Receptors, Interleukin-17</topic><topic>variant</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nada, Hesham</creatorcontrib><creatorcontrib>Hassan, Ranya</creatorcontrib><creatorcontrib>Ibrahim, Rasha Abd El‐Hamed</creatorcontrib><creatorcontrib>Abdelsalam, Omnia Emad</creatorcontrib><creatorcontrib>Fathy, Amal</creatorcontrib><creatorcontrib>Toraih, Eman Ali</creatorcontrib><creatorcontrib>Atwa, Mona A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cosmetic dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nada, Hesham</au><au>Hassan, Ranya</au><au>Ibrahim, Rasha Abd El‐Hamed</au><au>Abdelsalam, Omnia Emad</au><au>Fathy, Amal</au><au>Toraih, Eman Ali</au><au>Atwa, Mona A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin 17 receptor A haplotype analysis in chronic spontaneous urticaria: A preliminary study</atitle><jtitle>Journal of cosmetic dermatology</jtitle><addtitle>J Cosmet Dermatol</addtitle><date>2021-04</date><risdate>2021</risdate><volume>20</volume><issue>4</issue><spage>1331</spage><epage>1342</epage><pages>1331-1342</pages><issn>1473-2130</issn><eissn>1473-2165</eissn><abstract>Background
Chronic spontaneous urticaria (CSU) is a distressing skin disease. Family clustering and heterogeneity in the onset and progression indicate that susceptibility to CSU is a complex trait. In this study, we performed haplotype analysis for one of the key player gene, IL17RA, for CSU to test the association with disease susceptibility and severity.
Methodology
The study included 70 CSU patients and 30 healthy controls. The severity of the disease was evaluated by autologous serum skin test (ASST) and urticaria activity score (UAS). ASST test was done and quality of life was assessed using a questionnaire. Allelic discrimination analysis for rs4819554 and rs879577 was performed using real‐time polymerase chain reaction technology.
Results
Carriers of rs4819554*G were more prone to develop CSU than its counterpart (P = .039), while rs4819554*A allele displayed more severe phenotype in the form of more prolonged disease duration (P = .040), concurrent angioedema (P < .001), higher level of treatment (P < .001), and higher score of quality of life (P < .001). Additionally, homozygote patients with rs879577*CC were associated with angioedema (P < .001). Haplotype analysis revealed that cohorts with both rs4819554*A and rs879577*T conferred protection against developing CSU (OR = 0.07, 95% CI = 0.01‐0.32, P = .001).
Conclusion
Our results showed that IL17RA gene polymorphisms might contribute to the increased susceptibility to CSU.</abstract><cop>England</cop><pmid>32969586</pmid><doi>10.1111/jocd.13730</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-9267-3787</orcidid></addata></record> |
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| subjects | Chronic Disease chronic spontaneous urticaria Chronic Urticaria - genetics haplotype Haplotypes Humans IL‐17RA Quality of Life Receptors, Interleukin-17 variant |
| title | Interleukin 17 receptor A haplotype analysis in chronic spontaneous urticaria: A preliminary study |
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