Hypothalamic‐pituitary‐adrenal axis suppression in asthma: A glucocorticoid receptor polymorphism may protect

Background Asthmatic children on corticosteroids can develop hypothalamic‐pituitary‐adrenal axis suppression (HPAS). Single nucleotide polymorphisms (SNPs) rs242941 and rs1876828 of the corticotrophin‐releasing hormone receptor 1 (CRHR1) gene were associated with lower stimulated cortisol (F) levels...

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Veröffentlicht in:	Pediatric allergy and immunology 2021-02, Vol.32 (2), p.273-279
Hauptverfasser:	Akurugu, Wisdom Alemya, Van Heerden, Carel Jacobus, Mulder, Nicola, Zöllner, Ekkehard Werner, Kalaycı, Ömer
Format:	Artikel
Sprache:	eng
Schlagworte:	adrenal adrenal insufficiency Adrenocorticotropic hormone Alleles Asthma Children Corticosteroids Cortisol Gene polymorphism Glucocorticoids Hypothalamus Pituitary pituitary‐adrenal function tests Polymerase chain reaction polymorphism receptors Saliva Single-nucleotide polymorphism steroids/adverse events
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