Laser and light therapies for the treatment of necrobiosis lipoidica
Necrobiosis lipoidica (NL) is a rare, inflammatory granulomatous skin disorder involving collagen degeneration. In recent years, several light and laser therapies have been proposed and used in the treatment of NL with variable outcomes. The aim of the study was to investigate the efficacy and safet...
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| Veröffentlicht in: | Lasers in medical science 2021-04, Vol.36 (3), p.497-506 |
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| creator | Rajabi-Estarabadi, Ali Aickara, Divya J. Hirsch, Melanie Williams, Natalie M. Maranda, Eric L. Van Badiavas, Evangelos |
| description | Necrobiosis lipoidica (NL) is a rare, inflammatory granulomatous skin disorder involving collagen degeneration. In recent years, several light and laser therapies have been proposed and used in the treatment of NL with variable outcomes. The aim of the study was to investigate the efficacy and safety of lasers and light therapies for the treatment of NL. A review of PubMed was conducted to search for studies using laser and light therapies for the treatment of NL. Articles that employed a combination of treatment modalities were excluded. Twenty-four studies were reviewed. Light and laser therapies used in these studies included CO
2
laser, pulsed dye laser, methyl aminolevulinate (MAL)-photodynamic therapy (PDT), aminolevulinic acid (ALA)-PDT, ultraviolet A1 (UVA1) phototherapy, and psoralen plus ultraviolet-A (PUVA). PUVA was identified as the modality with the most available evidence (7 studies), followed by MAL-PDT and ALA-PDT (5 studies each), pulsed dye laser and UVA1 (3 studies each), and lastly CO
2
laser (2 studies). Most modalities demonstrated variable efficacies and side effects with the exception of PDL, which consistently showed successful outcomes. Multiple dermatologic light and laser therapies have been investigated for the treatment of NL, including PUVA, ALA-PDT, MAL-PDT, pulsed dye laser, UVA1, and CO
2
laser. However, a clear consensus on the preferred treatment is yet to be addressed. Each treatment option demonstrates both advantages and disadvantages that should be discussed with patients when selecting the treatment modality. |
| doi_str_mv | 10.1007/s10103-020-03147-3 |
| format | Article |
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2
laser, pulsed dye laser, methyl aminolevulinate (MAL)-photodynamic therapy (PDT), aminolevulinic acid (ALA)-PDT, ultraviolet A1 (UVA1) phototherapy, and psoralen plus ultraviolet-A (PUVA). PUVA was identified as the modality with the most available evidence (7 studies), followed by MAL-PDT and ALA-PDT (5 studies each), pulsed dye laser and UVA1 (3 studies each), and lastly CO
2
laser (2 studies). Most modalities demonstrated variable efficacies and side effects with the exception of PDL, which consistently showed successful outcomes. Multiple dermatologic light and laser therapies have been investigated for the treatment of NL, including PUVA, ALA-PDT, MAL-PDT, pulsed dye laser, UVA1, and CO
2
laser. However, a clear consensus on the preferred treatment is yet to be addressed. Each treatment option demonstrates both advantages and disadvantages that should be discussed with patients when selecting the treatment modality.</description><identifier>ISSN: 0268-8921</identifier><identifier>EISSN: 1435-604X</identifier><identifier>DOI: 10.1007/s10103-020-03147-3</identifier><identifier>PMID: 32970197</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Aminolevulinic acid ; Carbon dioxide ; Carbon dioxide lasers ; Collagen ; Degeneration ; Dentistry ; Dye lasers ; Dyes ; Humans ; Laser Therapy ; Lasers ; Lasers, Dye - therapeutic use ; Lasers, Gas - therapeutic use ; Light ; Medicine ; Medicine & Public Health ; Necrobiosis Lipoidica - therapy ; Optical Devices ; Optics ; Photochemotherapy ; Photodynamic therapy ; Photonics ; Phototherapy ; Psoralen ; Quantum Optics ; Review Article ; Side effects ; Skin diseases</subject><ispartof>Lasers in medical science, 2021-04, Vol.36 (3), p.497-506</ispartof><rights>Springer-Verlag London Ltd., part of Springer Nature 2020</rights><rights>Springer-Verlag London Ltd., part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-e6feb87763b6be87070df81ee2ab6febee8bc503ce15c5fbb7ddcee8649904b43</citedby><cites>FETCH-LOGICAL-c375t-e6feb87763b6be87070df81ee2ab6febee8bc503ce15c5fbb7ddcee8649904b43</cites><orcidid>0000-0002-3631-9844</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10103-020-03147-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10103-020-03147-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32970197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rajabi-Estarabadi, Ali</creatorcontrib><creatorcontrib>Aickara, Divya J.</creatorcontrib><creatorcontrib>Hirsch, Melanie</creatorcontrib><creatorcontrib>Williams, Natalie M.</creatorcontrib><creatorcontrib>Maranda, Eric L.</creatorcontrib><creatorcontrib>Van Badiavas, Evangelos</creatorcontrib><title>Laser and light therapies for the treatment of necrobiosis lipoidica</title><title>Lasers in medical science</title><addtitle>Lasers Med Sci</addtitle><addtitle>Lasers Med Sci</addtitle><description>Necrobiosis lipoidica (NL) is a rare, inflammatory granulomatous skin disorder involving collagen degeneration. In recent years, several light and laser therapies have been proposed and used in the treatment of NL with variable outcomes. The aim of the study was to investigate the efficacy and safety of lasers and light therapies for the treatment of NL. A review of PubMed was conducted to search for studies using laser and light therapies for the treatment of NL. Articles that employed a combination of treatment modalities were excluded. Twenty-four studies were reviewed. Light and laser therapies used in these studies included CO
2
laser, pulsed dye laser, methyl aminolevulinate (MAL)-photodynamic therapy (PDT), aminolevulinic acid (ALA)-PDT, ultraviolet A1 (UVA1) phototherapy, and psoralen plus ultraviolet-A (PUVA). PUVA was identified as the modality with the most available evidence (7 studies), followed by MAL-PDT and ALA-PDT (5 studies each), pulsed dye laser and UVA1 (3 studies each), and lastly CO
2
laser (2 studies). Most modalities demonstrated variable efficacies and side effects with the exception of PDL, which consistently showed successful outcomes. Multiple dermatologic light and laser therapies have been investigated for the treatment of NL, including PUVA, ALA-PDT, MAL-PDT, pulsed dye laser, UVA1, and CO
2
laser. However, a clear consensus on the preferred treatment is yet to be addressed. Each treatment option demonstrates both advantages and disadvantages that should be discussed with patients when selecting the treatment modality.</description><subject>Aminolevulinic acid</subject><subject>Carbon dioxide</subject><subject>Carbon dioxide lasers</subject><subject>Collagen</subject><subject>Degeneration</subject><subject>Dentistry</subject><subject>Dye lasers</subject><subject>Dyes</subject><subject>Humans</subject><subject>Laser Therapy</subject><subject>Lasers</subject><subject>Lasers, Dye - therapeutic use</subject><subject>Lasers, Gas - therapeutic use</subject><subject>Light</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Necrobiosis Lipoidica - therapy</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Photochemotherapy</subject><subject>Photodynamic therapy</subject><subject>Photonics</subject><subject>Phototherapy</subject><subject>Psoralen</subject><subject>Quantum Optics</subject><subject>Review Article</subject><subject>Side effects</subject><subject>Skin diseases</subject><issn>0268-8921</issn><issn>1435-604X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kLtOxDAQRS0EYpeFH6BAkWhoAuNH7KREvKWVaECis-xksptVXthJwd_jJQtIFFQjz5x7x3MJOaVwSQHUladAgcfAIAZOhYr5HplTwZNYgnjbJ3NgMo3TjNEZOfJ-A0CVpPyQzDjLFNBMzcnt0nh0kWmLqK5W6yEa1uhMX6GPys5tX9Hg0AwNtkPUlVGLuets1fnKB0HfVUWVm2NyUJra48muLsjr_d3LzWO8fH54urlexjlXyRCjLNGmSklupcVUgYKiTCkiM3Y7QkxtngDPkSZ5UlqriiIPTSmyDIQVfEEuJt_ede8j-kE3lc-xrk2L3eg1EyLJZBbuDOj5H3TTja4Nv9MsCYBkjGWBYhMVjvLeYal7VzXGfWgKepuxnjLWIWP9lbHmQXS2sx5tg8WP5DvUAPAJ8GHUrtD97v7H9hMWnIdB</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Rajabi-Estarabadi, Ali</creator><creator>Aickara, Divya J.</creator><creator>Hirsch, Melanie</creator><creator>Williams, Natalie M.</creator><creator>Maranda, Eric L.</creator><creator>Van Badiavas, Evangelos</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7SP</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L7M</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3631-9844</orcidid></search><sort><creationdate>20210401</creationdate><title>Laser and light therapies for the treatment of necrobiosis lipoidica</title><author>Rajabi-Estarabadi, Ali ; Aickara, Divya J. ; Hirsch, Melanie ; Williams, Natalie M. ; Maranda, Eric L. ; Van Badiavas, Evangelos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-e6feb87763b6be87070df81ee2ab6febee8bc503ce15c5fbb7ddcee8649904b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aminolevulinic acid</topic><topic>Carbon dioxide</topic><topic>Carbon dioxide lasers</topic><topic>Collagen</topic><topic>Degeneration</topic><topic>Dentistry</topic><topic>Dye lasers</topic><topic>Dyes</topic><topic>Humans</topic><topic>Laser Therapy</topic><topic>Lasers</topic><topic>Lasers, Dye - 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Academic</collection><jtitle>Lasers in medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rajabi-Estarabadi, Ali</au><au>Aickara, Divya J.</au><au>Hirsch, Melanie</au><au>Williams, Natalie M.</au><au>Maranda, Eric L.</au><au>Van Badiavas, Evangelos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Laser and light therapies for the treatment of necrobiosis lipoidica</atitle><jtitle>Lasers in medical science</jtitle><stitle>Lasers Med Sci</stitle><addtitle>Lasers Med Sci</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>36</volume><issue>3</issue><spage>497</spage><epage>506</epage><pages>497-506</pages><issn>0268-8921</issn><eissn>1435-604X</eissn><abstract>Necrobiosis lipoidica (NL) is a rare, inflammatory granulomatous skin disorder involving collagen degeneration. In recent years, several light and laser therapies have been proposed and used in the treatment of NL with variable outcomes. The aim of the study was to investigate the efficacy and safety of lasers and light therapies for the treatment of NL. A review of PubMed was conducted to search for studies using laser and light therapies for the treatment of NL. Articles that employed a combination of treatment modalities were excluded. Twenty-four studies were reviewed. Light and laser therapies used in these studies included CO
2
laser, pulsed dye laser, methyl aminolevulinate (MAL)-photodynamic therapy (PDT), aminolevulinic acid (ALA)-PDT, ultraviolet A1 (UVA1) phototherapy, and psoralen plus ultraviolet-A (PUVA). PUVA was identified as the modality with the most available evidence (7 studies), followed by MAL-PDT and ALA-PDT (5 studies each), pulsed dye laser and UVA1 (3 studies each), and lastly CO
2
laser (2 studies). Most modalities demonstrated variable efficacies and side effects with the exception of PDL, which consistently showed successful outcomes. Multiple dermatologic light and laser therapies have been investigated for the treatment of NL, including PUVA, ALA-PDT, MAL-PDT, pulsed dye laser, UVA1, and CO
2
laser. However, a clear consensus on the preferred treatment is yet to be addressed. Each treatment option demonstrates both advantages and disadvantages that should be discussed with patients when selecting the treatment modality.</abstract><cop>London</cop><pub>Springer London</pub><pmid>32970197</pmid><doi>10.1007/s10103-020-03147-3</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3631-9844</orcidid></addata></record> |
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| subjects | Aminolevulinic acid Carbon dioxide Carbon dioxide lasers Collagen Degeneration Dentistry Dye lasers Dyes Humans Laser Therapy Lasers Lasers, Dye - therapeutic use Lasers, Gas - therapeutic use Light Medicine Medicine & Public Health Necrobiosis Lipoidica - therapy Optical Devices Optics Photochemotherapy Photodynamic therapy Photonics Phototherapy Psoralen Quantum Optics Review Article Side effects Skin diseases |
| title | Laser and light therapies for the treatment of necrobiosis lipoidica |
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