Soy and isoflavone consumption and subsequent risk of prostate cancer mortality: the Japan Public Health Center-based Prospective Study
Abstract Background Although many epidemiological studies have reported the preventive effects of soy products and isoflavones on prostate cancer, our previous studies reported that the association between soy and isoflavones and prostate cancer incidence differed according to stage. It is more impo...
Gespeichert in:
| Veröffentlicht in: | International journal of epidemiology 2020-10, Vol.49 (5), p.1553-1561 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1561 |
|---|---|
| container_issue | 5 |
| container_start_page | 1553 |
| container_title | International journal of epidemiology |
| container_volume | 49 |
| creator | Sawada, Norie Iwasaki, Motoki Yamaji, Taiki Shimazu, Taichi Inoue, Manami Tsugane, Shoichiro |
| description | Abstract
Background
Although many epidemiological studies have reported the preventive effects of soy products and isoflavones on prostate cancer, our previous studies reported that the association between soy and isoflavones and prostate cancer incidence differed according to stage. It is more important to identify modifiable risk factors related to lethal prostate cancer. Here, we investigated the association between soy, soy products and isoflavones intake and prostate cancer mortality, in a prospective study in Japan.
Methods
We conducted a population-based prospective study in 43 580 Japanese men with no history of cancer or cardiovascular disease (aged 45-74 years). Participants completed a validated questionnaire which included 138 food items. We followed participants from 1995 to 2016. Hazard ratios (HRs) and 95% confidence intervals (CIs) of prostate cancer mortality were calculated according to quintiles of soy products and isoflavones intake, using Cox hazard proportional hazards regression.
Results
During 16.9 years follow-up, we registered 221 deaths from prostate cancer. Isoflavones and soy products intake was associated with an increased risk of prostate cancer death, with multivariate HRQ5 vs. Q1=1.39, 95% CI = 0.87-2.20, p for trend = 0.04 for isoflavones and multivariate HRQ5 vs. Q1=1.76, 95% CI = 1.10-2.82, p for trend = 0.04 for soy food.
Conclusions
Our study suggested that high intake of soy and isoflavones might increase the risk of prostate cancer mortality. |
| doi_str_mv | 10.1093/ije/dyaa177 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_webof</sourceid><recordid>TN_cdi_proquest_miscellaneous_2445967781</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ije/dyaa177</oup_id><sourcerecordid>2445967781</sourcerecordid><originalsourceid>FETCH-LOGICAL-c423t-58746c606f410f9a69e90063a33716234d61f05654e65b1b84c99d5d2151749b3</originalsourceid><addsrcrecordid>eNqNkU9rFTEUxYMo9llduZesRJCxyeTfxJ0Mai0FC9X1kMncoakzyThJKvMJ-rUbfc92J65yIb9zuOdchF5S8o4SzU7cNZwMmzFUqUdoR7nkFZONeIx2hBFSCaXoEXoW4zUhlHOun6IjVmvZqIbv0O1l2LDxA3YxjJO5CR6wDT7meUku-D9fMfcRfmbwCa8u_sBhxMsaYjKpsMZbWPEc1mQml7b3OF0BPjOL8fgi95Oz-BTMlK5wW_SwVr2JMOCLol_AJncD-DLlYXuOnoxmivDi8B6j758-fmtPq_Ovn7-0H84ry2uWKtEoLq0kcuSUjNpIDZoQyQxjisqa8UHSkQgpOEjR077hVutBDDUVVHHds2P0Zu9bEpRIMXWzixamyXgIOXY150JLpRpa0Ld71JZl4wpjt6xuNuvWUdL9br4rzXeH5gv96mCc-xmGe_Zv1Q92v6APY7QOSnP3GCkpiFRU8DLVotDN_9OtK7co12pD9qlIX--lIS__XPkO2l-uuA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2445967781</pqid></control><display><type>article</type><title>Soy and isoflavone consumption and subsequent risk of prostate cancer mortality: the Japan Public Health Center-based Prospective Study</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>Alma/SFX Local Collection</source><creator>Sawada, Norie ; Iwasaki, Motoki ; Yamaji, Taiki ; Shimazu, Taichi ; Inoue, Manami ; Tsugane, Shoichiro</creator><creatorcontrib>Sawada, Norie ; Iwasaki, Motoki ; Yamaji, Taiki ; Shimazu, Taichi ; Inoue, Manami ; Tsugane, Shoichiro ; Japan Public Hlth Ctr-Based Prospe ; Japan Public Health Center-based Prospective Study Group ; for the Japan Public Health Center-based Prospective Study Group</creatorcontrib><description>Abstract
Background
Although many epidemiological studies have reported the preventive effects of soy products and isoflavones on prostate cancer, our previous studies reported that the association between soy and isoflavones and prostate cancer incidence differed according to stage. It is more important to identify modifiable risk factors related to lethal prostate cancer. Here, we investigated the association between soy, soy products and isoflavones intake and prostate cancer mortality, in a prospective study in Japan.
Methods
We conducted a population-based prospective study in 43 580 Japanese men with no history of cancer or cardiovascular disease (aged 45-74 years). Participants completed a validated questionnaire which included 138 food items. We followed participants from 1995 to 2016. Hazard ratios (HRs) and 95% confidence intervals (CIs) of prostate cancer mortality were calculated according to quintiles of soy products and isoflavones intake, using Cox hazard proportional hazards regression.
Results
During 16.9 years follow-up, we registered 221 deaths from prostate cancer. Isoflavones and soy products intake was associated with an increased risk of prostate cancer death, with multivariate HRQ5 vs. Q1=1.39, 95% CI = 0.87-2.20, p for trend = 0.04 for isoflavones and multivariate HRQ5 vs. Q1=1.76, 95% CI = 1.10-2.82, p for trend = 0.04 for soy food.
Conclusions
Our study suggested that high intake of soy and isoflavones might increase the risk of prostate cancer mortality.</description><identifier>ISSN: 0300-5771</identifier><identifier>EISSN: 1464-3685</identifier><identifier>DOI: 10.1093/ije/dyaa177</identifier><identifier>PMID: 32968784</identifier><language>eng</language><publisher>OXFORD: Oxford University Press</publisher><subject>Aged ; Diet ; Humans ; Isoflavones ; Japan - epidemiology ; Life Sciences & Biomedicine ; Male ; Middle Aged ; Prospective Studies ; Prostatic Neoplasms - epidemiology ; Public Health ; Public, Environmental & Occupational Health ; Risk Factors ; Science & Technology ; Soy Foods ; Surveys and Questionnaires</subject><ispartof>International journal of epidemiology, 2020-10, Vol.49 (5), p.1553-1561</ispartof><rights>The Author(s) 2020; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association 2020</rights><rights>The Author(s) 2020; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>8</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000606715400025</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c423t-58746c606f410f9a69e90063a33716234d61f05654e65b1b84c99d5d2151749b3</citedby><cites>FETCH-LOGICAL-c423t-58746c606f410f9a69e90063a33716234d61f05654e65b1b84c99d5d2151749b3</cites><orcidid>0000-0002-9936-1476 ; 0000-0001-6000-9830 ; 0000-0003-1276-2398</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1585,27929,27930,28253</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32968784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sawada, Norie</creatorcontrib><creatorcontrib>Iwasaki, Motoki</creatorcontrib><creatorcontrib>Yamaji, Taiki</creatorcontrib><creatorcontrib>Shimazu, Taichi</creatorcontrib><creatorcontrib>Inoue, Manami</creatorcontrib><creatorcontrib>Tsugane, Shoichiro</creatorcontrib><creatorcontrib>Japan Public Hlth Ctr-Based Prospe</creatorcontrib><creatorcontrib>Japan Public Health Center-based Prospective Study Group</creatorcontrib><creatorcontrib>for the Japan Public Health Center-based Prospective Study Group</creatorcontrib><title>Soy and isoflavone consumption and subsequent risk of prostate cancer mortality: the Japan Public Health Center-based Prospective Study</title><title>International journal of epidemiology</title><addtitle>INT J EPIDEMIOL</addtitle><addtitle>Int J Epidemiol</addtitle><description>Abstract
Background
Although many epidemiological studies have reported the preventive effects of soy products and isoflavones on prostate cancer, our previous studies reported that the association between soy and isoflavones and prostate cancer incidence differed according to stage. It is more important to identify modifiable risk factors related to lethal prostate cancer. Here, we investigated the association between soy, soy products and isoflavones intake and prostate cancer mortality, in a prospective study in Japan.
Methods
We conducted a population-based prospective study in 43 580 Japanese men with no history of cancer or cardiovascular disease (aged 45-74 years). Participants completed a validated questionnaire which included 138 food items. We followed participants from 1995 to 2016. Hazard ratios (HRs) and 95% confidence intervals (CIs) of prostate cancer mortality were calculated according to quintiles of soy products and isoflavones intake, using Cox hazard proportional hazards regression.
Results
During 16.9 years follow-up, we registered 221 deaths from prostate cancer. Isoflavones and soy products intake was associated with an increased risk of prostate cancer death, with multivariate HRQ5 vs. Q1=1.39, 95% CI = 0.87-2.20, p for trend = 0.04 for isoflavones and multivariate HRQ5 vs. Q1=1.76, 95% CI = 1.10-2.82, p for trend = 0.04 for soy food.
Conclusions
Our study suggested that high intake of soy and isoflavones might increase the risk of prostate cancer mortality.</description><subject>Aged</subject><subject>Diet</subject><subject>Humans</subject><subject>Isoflavones</subject><subject>Japan - epidemiology</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Public Health</subject><subject>Public, Environmental & Occupational Health</subject><subject>Risk Factors</subject><subject>Science & Technology</subject><subject>Soy Foods</subject><subject>Surveys and Questionnaires</subject><issn>0300-5771</issn><issn>1464-3685</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqNkU9rFTEUxYMo9llduZesRJCxyeTfxJ0Mai0FC9X1kMncoakzyThJKvMJ-rUbfc92J65yIb9zuOdchF5S8o4SzU7cNZwMmzFUqUdoR7nkFZONeIx2hBFSCaXoEXoW4zUhlHOun6IjVmvZqIbv0O1l2LDxA3YxjJO5CR6wDT7meUku-D9fMfcRfmbwCa8u_sBhxMsaYjKpsMZbWPEc1mQml7b3OF0BPjOL8fgi95Oz-BTMlK5wW_SwVr2JMOCLol_AJncD-DLlYXuOnoxmivDi8B6j758-fmtPq_Ovn7-0H84ry2uWKtEoLq0kcuSUjNpIDZoQyQxjisqa8UHSkQgpOEjR077hVutBDDUVVHHds2P0Zu9bEpRIMXWzixamyXgIOXY150JLpRpa0Ld71JZl4wpjt6xuNuvWUdL9br4rzXeH5gv96mCc-xmGe_Zv1Q92v6APY7QOSnP3GCkpiFRU8DLVotDN_9OtK7co12pD9qlIX--lIS__XPkO2l-uuA</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Sawada, Norie</creator><creator>Iwasaki, Motoki</creator><creator>Yamaji, Taiki</creator><creator>Shimazu, Taichi</creator><creator>Inoue, Manami</creator><creator>Tsugane, Shoichiro</creator><general>Oxford University Press</general><general>Oxford Univ Press</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9936-1476</orcidid><orcidid>https://orcid.org/0000-0001-6000-9830</orcidid><orcidid>https://orcid.org/0000-0003-1276-2398</orcidid></search><sort><creationdate>20201001</creationdate><title>Soy and isoflavone consumption and subsequent risk of prostate cancer mortality: the Japan Public Health Center-based Prospective Study</title><author>Sawada, Norie ; Iwasaki, Motoki ; Yamaji, Taiki ; Shimazu, Taichi ; Inoue, Manami ; Tsugane, Shoichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-58746c606f410f9a69e90063a33716234d61f05654e65b1b84c99d5d2151749b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Diet</topic><topic>Humans</topic><topic>Isoflavones</topic><topic>Japan - epidemiology</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Prostatic Neoplasms - epidemiology</topic><topic>Public Health</topic><topic>Public, Environmental & Occupational Health</topic><topic>Risk Factors</topic><topic>Science & Technology</topic><topic>Soy Foods</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sawada, Norie</creatorcontrib><creatorcontrib>Iwasaki, Motoki</creatorcontrib><creatorcontrib>Yamaji, Taiki</creatorcontrib><creatorcontrib>Shimazu, Taichi</creatorcontrib><creatorcontrib>Inoue, Manami</creatorcontrib><creatorcontrib>Tsugane, Shoichiro</creatorcontrib><creatorcontrib>Japan Public Hlth Ctr-Based Prospe</creatorcontrib><creatorcontrib>Japan Public Health Center-based Prospective Study Group</creatorcontrib><creatorcontrib>for the Japan Public Health Center-based Prospective Study Group</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sawada, Norie</au><au>Iwasaki, Motoki</au><au>Yamaji, Taiki</au><au>Shimazu, Taichi</au><au>Inoue, Manami</au><au>Tsugane, Shoichiro</au><aucorp>Japan Public Hlth Ctr-Based Prospe</aucorp><aucorp>Japan Public Health Center-based Prospective Study Group</aucorp><aucorp>for the Japan Public Health Center-based Prospective Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soy and isoflavone consumption and subsequent risk of prostate cancer mortality: the Japan Public Health Center-based Prospective Study</atitle><jtitle>International journal of epidemiology</jtitle><stitle>INT J EPIDEMIOL</stitle><addtitle>Int J Epidemiol</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>49</volume><issue>5</issue><spage>1553</spage><epage>1561</epage><pages>1553-1561</pages><issn>0300-5771</issn><eissn>1464-3685</eissn><abstract>Abstract
Background
Although many epidemiological studies have reported the preventive effects of soy products and isoflavones on prostate cancer, our previous studies reported that the association between soy and isoflavones and prostate cancer incidence differed according to stage. It is more important to identify modifiable risk factors related to lethal prostate cancer. Here, we investigated the association between soy, soy products and isoflavones intake and prostate cancer mortality, in a prospective study in Japan.
Methods
We conducted a population-based prospective study in 43 580 Japanese men with no history of cancer or cardiovascular disease (aged 45-74 years). Participants completed a validated questionnaire which included 138 food items. We followed participants from 1995 to 2016. Hazard ratios (HRs) and 95% confidence intervals (CIs) of prostate cancer mortality were calculated according to quintiles of soy products and isoflavones intake, using Cox hazard proportional hazards regression.
Results
During 16.9 years follow-up, we registered 221 deaths from prostate cancer. Isoflavones and soy products intake was associated with an increased risk of prostate cancer death, with multivariate HRQ5 vs. Q1=1.39, 95% CI = 0.87-2.20, p for trend = 0.04 for isoflavones and multivariate HRQ5 vs. Q1=1.76, 95% CI = 1.10-2.82, p for trend = 0.04 for soy food.
Conclusions
Our study suggested that high intake of soy and isoflavones might increase the risk of prostate cancer mortality.</abstract><cop>OXFORD</cop><pub>Oxford University Press</pub><pmid>32968784</pmid><doi>10.1093/ije/dyaa177</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9936-1476</orcidid><orcidid>https://orcid.org/0000-0001-6000-9830</orcidid><orcidid>https://orcid.org/0000-0003-1276-2398</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-5771 |
| ispartof | International journal of epidemiology, 2020-10, Vol.49 (5), p.1553-1561 |
| issn | 0300-5771 1464-3685 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2445967781 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Alma/SFX Local Collection |
| subjects | Aged Diet Humans Isoflavones Japan - epidemiology Life Sciences & Biomedicine Male Middle Aged Prospective Studies Prostatic Neoplasms - epidemiology Public Health Public, Environmental & Occupational Health Risk Factors Science & Technology Soy Foods Surveys and Questionnaires |
| title | Soy and isoflavone consumption and subsequent risk of prostate cancer mortality: the Japan Public Health Center-based Prospective Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T14%3A20%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_webof&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Soy%20and%20isoflavone%20consumption%20and%20subsequent%20risk%20of%20prostate%20cancer%20mortality:%20the%20Japan%20Public%20Health%20Center-based%20Prospective%20Study&rft.jtitle=International%20journal%20of%20epidemiology&rft.au=Sawada,%20Norie&rft.aucorp=Japan%20Public%20Hlth%20Ctr-Based%20Prospe&rft.date=2020-10-01&rft.volume=49&rft.issue=5&rft.spage=1553&rft.epage=1561&rft.pages=1553-1561&rft.issn=0300-5771&rft.eissn=1464-3685&rft_id=info:doi/10.1093/ije/dyaa177&rft_dat=%3Cproquest_webof%3E2445967781%3C/proquest_webof%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2445967781&rft_id=info:pmid/32968784&rft_oup_id=10.1093/ije/dyaa177&rfr_iscdi=true |