Electrical stimulation applied during differentiation drives the hiPSC-CMs towards a mature cardiac conduction-like cells

Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) resemble fetal cardiomyocytes and electrical stimulation (ES) has been explored to mature the differentiated cells. Here, we hypothesize that ES applied at the beginning of the differentiation process, triggers both differentiati...

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Veröffentlicht in:	Biochemical and biophysical research communications 2020-12, Vol.533 (3), p.376-382
Hauptverfasser:	Crestani, Thayane, Steichen, Clara, Neri, Elida, Rodrigues, Mariliza, Fonseca-Alaniz, Miriam Helena, Ormrod, Beth, Holt, Mark R., Pandey, Pragati, Harding, Sian, Ehler, Elisabeth, Krieger, Jose E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology beta Catenin - genetics beta Catenin - metabolism Biomarkers - metabolism Calcium - metabolism Cell Differentiation Cell- and Tissue-Based Therapy - methods Connexins - genetics Connexins - metabolism Contactin 2 - genetics Contactin 2 - metabolism Differentiation Electric Stimulation Electrical stimulation Gap Junction alpha-5 Protein Gene Expression Heart Conduction System - cytology Heart Conduction System - physiology Homeobox Protein Nkx-2.5 - genetics Homeobox Protein Nkx-2.5 - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Human induced pluripotent stem cells derived cardiomyocytes Humans Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - genetics Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - physiology Maturation Muscle Proteins - genetics Muscle Proteins - metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - physiology NAV1.5 Voltage-Gated Sodium Channel - genetics NAV1.5 Voltage-Gated Sodium Channel - metabolism Potassium Channels - genetics Potassium Channels - metabolism Primary Cell Culture Specialized cardiac conduction cells Transcription Factors - genetics Transcription Factors - metabolism Troponin I - genetics Troponin I - metabolism
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