The clinical relevance of the microbiome when managing paediatric infectious diseases—Narrative review
In recent years, the field of infectious diseases has been hit by the overwhelming amount of information generated while the human microbiome is being disentangled. Based on the interaction between the microbiota and the immune system, the implications regarding infectious diseases are probably majo...
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| Veröffentlicht in: | Acta Paediatrica 2021-02, Vol.110 (2), p.441-449 |
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| container_title | Acta Paediatrica |
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| creator | Sainz, Talía Delgado, Jaime Mendez‐Echevarría, Ana Santiago, Begoña Lopez‐Varela, Elisa Aguilera‐Alonso, David Saavedra‐Lozano, Jesús Rodríguez‐Fernández, Rosa Holguín, África Navarro, Marisa L. Muñoz‐Fernández, María Ángeles Rivero‐Calle, Irene Solana, María José López‐Herce, Jesús Calvo, Cristina |
| description | In recent years, the field of infectious diseases has been hit by the overwhelming amount of information generated while the human microbiome is being disentangled. Based on the interaction between the microbiota and the immune system, the implications regarding infectious diseases are probably major and remain a challenge.
Aims
This review was conceived as a comprehensive tool to provide an overview of the available evidence regarding the influence of the microbiome on infectious diseases in children.
Methods
We present the main findings aroused from microbiome research in prevention, diagnosis and treatment of infectious disease under a paediatric perspective, to inform clinicians of the potential relevance of microbiome‐related knowledge for translation to clinical practice.
Results and Conclusion
The evidence shown in this review highlights the numerous research gaps ahead and supports the need to move forward to integrating the so‐called microbiome thinking into our routine clinical practice. |
| doi_str_mv | 10.1111/apa.15578 |
| format | Article |
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Aims
This review was conceived as a comprehensive tool to provide an overview of the available evidence regarding the influence of the microbiome on infectious diseases in children.
Methods
We present the main findings aroused from microbiome research in prevention, diagnosis and treatment of infectious disease under a paediatric perspective, to inform clinicians of the potential relevance of microbiome‐related knowledge for translation to clinical practice.
Results and Conclusion
The evidence shown in this review highlights the numerous research gaps ahead and supports the need to move forward to integrating the so‐called microbiome thinking into our routine clinical practice.</description><identifier>ISSN: 0803-5253</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/apa.15578</identifier><identifier>PMID: 32961592</identifier><language>eng</language><publisher>Norway: Wiley Subscription Services, Inc</publisher><subject>Child ; children ; Clinical medicine ; Communicable Diseases - therapy ; Humans ; Immune system ; Infectious diseases ; microbiome ; Microbiomes ; Microbiota ; Pediatrics ; pre‐ and probiotics ; Reviews</subject><ispartof>Acta Paediatrica, 2021-02, Vol.110 (2), p.441-449</ispartof><rights>2020 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd</rights><rights>2020 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd.</rights><rights>2021 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3138-3c191c8649303a6b413da0ba9bbf1e7906a62669c13a08858ac00dab9ba901df3</cites><orcidid>0000-0002-5301-0945 ; 0000-0002-7455-9080 ; 0000-0002-6503-3423</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapa.15578$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapa.15578$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32961592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sainz, Talía</creatorcontrib><creatorcontrib>Delgado, Jaime</creatorcontrib><creatorcontrib>Mendez‐Echevarría, Ana</creatorcontrib><creatorcontrib>Santiago, Begoña</creatorcontrib><creatorcontrib>Lopez‐Varela, Elisa</creatorcontrib><creatorcontrib>Aguilera‐Alonso, David</creatorcontrib><creatorcontrib>Saavedra‐Lozano, Jesús</creatorcontrib><creatorcontrib>Rodríguez‐Fernández, Rosa</creatorcontrib><creatorcontrib>Holguín, África</creatorcontrib><creatorcontrib>Navarro, Marisa L.</creatorcontrib><creatorcontrib>Muñoz‐Fernández, María Ángeles</creatorcontrib><creatorcontrib>Rivero‐Calle, Irene</creatorcontrib><creatorcontrib>Solana, María José</creatorcontrib><creatorcontrib>López‐Herce, Jesús</creatorcontrib><creatorcontrib>Calvo, Cristina</creatorcontrib><title>The clinical relevance of the microbiome when managing paediatric infectious diseases—Narrative review</title><title>Acta Paediatrica</title><addtitle>Acta Paediatr</addtitle><description>In recent years, the field of infectious diseases has been hit by the overwhelming amount of information generated while the human microbiome is being disentangled. Based on the interaction between the microbiota and the immune system, the implications regarding infectious diseases are probably major and remain a challenge.
Aims
This review was conceived as a comprehensive tool to provide an overview of the available evidence regarding the influence of the microbiome on infectious diseases in children.
Methods
We present the main findings aroused from microbiome research in prevention, diagnosis and treatment of infectious disease under a paediatric perspective, to inform clinicians of the potential relevance of microbiome‐related knowledge for translation to clinical practice.
Results and Conclusion
The evidence shown in this review highlights the numerous research gaps ahead and supports the need to move forward to integrating the so‐called microbiome thinking into our routine clinical practice.</description><subject>Child</subject><subject>children</subject><subject>Clinical medicine</subject><subject>Communicable Diseases - therapy</subject><subject>Humans</subject><subject>Immune system</subject><subject>Infectious diseases</subject><subject>microbiome</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Pediatrics</subject><subject>pre‐ and probiotics</subject><subject>Reviews</subject><issn>0803-5253</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1O3DAQgK2Kqiy0h75AZamXcgh47NiJj6tV-ZEQ7YGeo4kzYY3ys7Wzu-LGQ_CEPEkNSzkgMZc5zKdPo4-xryCOIc0JrvAYtC7KD2wGRkMmpSz22EyUQmVaarXPDmK8FUIqm5tPbF9Ja0BbOWPL6yVx1_nBO-x4oI42ODjiY8undOm9C2Ptx574dkkD73HAGz_c8BVS43EK3nE_tOQmP64jb3wkjBQf7x-uMASc_IaSdONp-5l9bLGL9OVlH7I_pz-vF-fZ5a-zi8X8MnMKVJkpBxZcaXKrhEJT56AaFDXaum6BCisMGmmMdaBQlKUu0QnRYG0TIqBp1SH7sfOuwvh3TXGqeh8ddR0OlF6sZJ7rXJYAMqHf36C34zoM6btEFVbnIPIiUUc7KpWIMVBbrYLvMdxVIKqn_FXKXz3nT-y3F-O67ql5Jf_3TsDJDtj6ju7eN1Xz3_Od8h-nDI_r</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Sainz, Talía</creator><creator>Delgado, Jaime</creator><creator>Mendez‐Echevarría, Ana</creator><creator>Santiago, Begoña</creator><creator>Lopez‐Varela, Elisa</creator><creator>Aguilera‐Alonso, David</creator><creator>Saavedra‐Lozano, Jesús</creator><creator>Rodríguez‐Fernández, Rosa</creator><creator>Holguín, África</creator><creator>Navarro, Marisa L.</creator><creator>Muñoz‐Fernández, María Ángeles</creator><creator>Rivero‐Calle, Irene</creator><creator>Solana, María José</creator><creator>López‐Herce, Jesús</creator><creator>Calvo, Cristina</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5301-0945</orcidid><orcidid>https://orcid.org/0000-0002-7455-9080</orcidid><orcidid>https://orcid.org/0000-0002-6503-3423</orcidid></search><sort><creationdate>202102</creationdate><title>The clinical relevance of the microbiome when managing paediatric infectious diseases—Narrative review</title><author>Sainz, Talía ; Delgado, Jaime ; Mendez‐Echevarría, Ana ; Santiago, Begoña ; Lopez‐Varela, Elisa ; Aguilera‐Alonso, David ; Saavedra‐Lozano, Jesús ; Rodríguez‐Fernández, Rosa ; Holguín, África ; Navarro, Marisa L. ; Muñoz‐Fernández, María Ángeles ; Rivero‐Calle, Irene ; Solana, María José ; López‐Herce, Jesús ; Calvo, Cristina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3138-3c191c8649303a6b413da0ba9bbf1e7906a62669c13a08858ac00dab9ba901df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Child</topic><topic>children</topic><topic>Clinical medicine</topic><topic>Communicable Diseases - therapy</topic><topic>Humans</topic><topic>Immune system</topic><topic>Infectious diseases</topic><topic>microbiome</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Pediatrics</topic><topic>pre‐ and probiotics</topic><topic>Reviews</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sainz, Talía</creatorcontrib><creatorcontrib>Delgado, Jaime</creatorcontrib><creatorcontrib>Mendez‐Echevarría, Ana</creatorcontrib><creatorcontrib>Santiago, Begoña</creatorcontrib><creatorcontrib>Lopez‐Varela, Elisa</creatorcontrib><creatorcontrib>Aguilera‐Alonso, David</creatorcontrib><creatorcontrib>Saavedra‐Lozano, Jesús</creatorcontrib><creatorcontrib>Rodríguez‐Fernández, Rosa</creatorcontrib><creatorcontrib>Holguín, África</creatorcontrib><creatorcontrib>Navarro, Marisa L.</creatorcontrib><creatorcontrib>Muñoz‐Fernández, María Ángeles</creatorcontrib><creatorcontrib>Rivero‐Calle, Irene</creatorcontrib><creatorcontrib>Solana, María José</creatorcontrib><creatorcontrib>López‐Herce, Jesús</creatorcontrib><creatorcontrib>Calvo, Cristina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sainz, Talía</au><au>Delgado, Jaime</au><au>Mendez‐Echevarría, Ana</au><au>Santiago, Begoña</au><au>Lopez‐Varela, Elisa</au><au>Aguilera‐Alonso, David</au><au>Saavedra‐Lozano, Jesús</au><au>Rodríguez‐Fernández, Rosa</au><au>Holguín, África</au><au>Navarro, Marisa L.</au><au>Muñoz‐Fernández, María Ángeles</au><au>Rivero‐Calle, Irene</au><au>Solana, María José</au><au>López‐Herce, Jesús</au><au>Calvo, Cristina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clinical relevance of the microbiome when managing paediatric infectious diseases—Narrative review</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>2021-02</date><risdate>2021</risdate><volume>110</volume><issue>2</issue><spage>441</spage><epage>449</epage><pages>441-449</pages><issn>0803-5253</issn><eissn>1651-2227</eissn><abstract>In recent years, the field of infectious diseases has been hit by the overwhelming amount of information generated while the human microbiome is being disentangled. Based on the interaction between the microbiota and the immune system, the implications regarding infectious diseases are probably major and remain a challenge.
Aims
This review was conceived as a comprehensive tool to provide an overview of the available evidence regarding the influence of the microbiome on infectious diseases in children.
Methods
We present the main findings aroused from microbiome research in prevention, diagnosis and treatment of infectious disease under a paediatric perspective, to inform clinicians of the potential relevance of microbiome‐related knowledge for translation to clinical practice.
Results and Conclusion
The evidence shown in this review highlights the numerous research gaps ahead and supports the need to move forward to integrating the so‐called microbiome thinking into our routine clinical practice.</abstract><cop>Norway</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32961592</pmid><doi>10.1111/apa.15578</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5301-0945</orcidid><orcidid>https://orcid.org/0000-0002-7455-9080</orcidid><orcidid>https://orcid.org/0000-0002-6503-3423</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Acta Paediatrica, 2021-02, Vol.110 (2), p.441-449 |
| issn | 0803-5253 1651-2227 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Child children Clinical medicine Communicable Diseases - therapy Humans Immune system Infectious diseases microbiome Microbiomes Microbiota Pediatrics pre‐ and probiotics Reviews |
| title | The clinical relevance of the microbiome when managing paediatric infectious diseases—Narrative review |
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