An apoptosis-dependent checkpoint for autoimmunity in memory B and plasma cells

B lymphocytes acquire self-reactivity as an unavoidable byproduct of antibody gene diversification in the bone marrow and in germinal centers (GCs). Autoreactive B cells emerging from the bone marrow are silenced in a series of well-defined checkpoints, but less is known about how self-reactivity th...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-10, Vol.117 (40), p.24957-24963
Hauptverfasser:	Mayer, Christian T., Nieke, Jan P., Gazumyan, Anna, Cipolla, Melissa, Wang, Qiao, Oliveira, Thiago Y., Ramos, Victor, Monette, Sébastien, Li, Quan-Zhen, Gershwin, M. Eric, Kashkar, Hamid, Nussenzweig, Michel C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Antinuclear - immunology Antinuclear antibodies Apoptosis Apoptosis - genetics Apoptosis - immunology Autoantibodies Autoantibodies - immunology Autoimmunity Autoimmunity - genetics Autoimmunity - immunology B-Lymphocytes - immunology Biological Sciences Bone marrow Genes, Immunoglobulin - genetics Genes, Immunoglobulin - immunology Germinal Center - immunology Germinal centers Humans Immune Tolerance - genetics Immunologic Memory - genetics Immunologic Memory - immunology Immunological memory Immunological tolerance Lymphocytes Lymphocytes B Memory cells Mice Multidisciplinary Sciences Mutation Plasma cells Plasma Cells - immunology Science & Technology Science & Technology - Other Topics
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