Efficient two-stage sequential arrays of proof of concept studies for pharmaceutical portfolios

Previous work has shown that individual randomized “proof-of-concept” (PoC) studies may be designed to maximize cost-effectiveness, subject to an overall PoC budget constraint. Maximizing cost-effectiveness has also been considered for arrays of simultaneously executed PoC studies. Defining Type III...

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Veröffentlicht in:	Statistical methods in medical research 2021-02, Vol.30 (2), p.396-410
Hauptverfasser:	He, Linchen, Du, Linqiu, Antonijevic, Zoran, Posch, Martin, Korostyshevskiy, Valeriy R, Beckman, Robert A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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