Congestive heart failure in COX2 deficient rats

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin (PG) formation by targeting cyclooxygenase (COX) 1 and 2. Long-term use of NSAIDs that selectively inhibit COX2 increases the risk for thrombotic events, cardiac failure, and hypertension. However, the underlying mechanisms remain...

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Veröffentlicht in:	Science China. Life sciences 2021-07, Vol.64 (7), p.1068-1076
Hauptverfasser:	Wan, Qiangyou, Kong, Deping, Liu, Qian, Guo, Shumin, Wang, Chenchen, Zhao, Yan, Ke, Zun-Ji, Yu, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biomarkers - metabolism Biomedical and Life Sciences Congestive heart failure Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - pharmacology Cyclooxygenase-1 Cyclooxygenase-2 Echocardiography Energy Metabolism Fibrosis Gene targeting Genotype Genotyping Glycolysis Heart failure Heart Failure - diagnostic imaging Heart Failure - drug therapy Heart Failure - metabolism Hexokinase Inflammation Life Sciences Mitochondria Nonsteroidal anti-inflammatory drugs Oxidation Pyruvate dehydrogenase (lipoamide) Pyruvic acid Rats Rats, Sprague-Dawley Research Paper Stroke Volume Ventricle
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