Early AGEing and metabolic diseases: is perinatal exposure to glycotoxins programming for adult-life metabolic syndrome?
Abstract Perinatal early nutritional disorders are critical for the developmental origins of health and disease. Glycotoxins, or advanced glycation end-products, and their precursors such as the methylglyoxal, which are formed endogenously and commonly found in processed foods and infant formulas, m...
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| Veröffentlicht in: | Nutrition reviews 2021-01, Vol.79 (1), p.13-24 |
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| creator | Francisco, Flávio A Saavedra, Lucas P J Junior, Marcos D F Barra, Cátia Matafome, Paulo Mathias, Paulo C F Gomes, Rodrigo M |
| description | Abstract
Perinatal early nutritional disorders are critical for the developmental origins of health and disease. Glycotoxins, or advanced glycation end-products, and their precursors such as the methylglyoxal, which are formed endogenously and commonly found in processed foods and infant formulas, may be associated with acute and long-term metabolic disorders. Besides general aspects of glycotoxins, such as their endogenous production, exogenous sources, and their role in the development of metabolic syndrome, we discuss in this review the sources of perinatal exposure to glycotoxins and their involvement in metabolic programming mechanisms. The role of perinatal glycotoxin exposure in the onset of insulin resistance, central nervous system development, cardiovascular diseases, and early aging also are discussed, as are possible interventions that may prevent or reduce such effects. |
| doi_str_mv | 10.1093/nutrit/nuaa074 |
| format | Article |
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Perinatal early nutritional disorders are critical for the developmental origins of health and disease. Glycotoxins, or advanced glycation end-products, and their precursors such as the methylglyoxal, which are formed endogenously and commonly found in processed foods and infant formulas, may be associated with acute and long-term metabolic disorders. Besides general aspects of glycotoxins, such as their endogenous production, exogenous sources, and their role in the development of metabolic syndrome, we discuss in this review the sources of perinatal exposure to glycotoxins and their involvement in metabolic programming mechanisms. The role of perinatal glycotoxin exposure in the onset of insulin resistance, central nervous system development, cardiovascular diseases, and early aging also are discussed, as are possible interventions that may prevent or reduce such effects.</description><identifier>ISSN: 0029-6643</identifier><identifier>EISSN: 1753-4887</identifier><identifier>DOI: 10.1093/nutrit/nuaa074</identifier><identifier>PMID: 32951053</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Aging ; Animals ; Female ; Fetus ; Glycation End Products, Advanced - metabolism ; Glycation End Products, Advanced - toxicity ; Humans ; Infant ; Infant, Newborn ; Insulin Resistance ; Metabolic Syndrome - etiology ; Metabolic Syndrome - metabolism ; Metabolic Syndrome - physiopathology ; Oxidative Stress ; Pregnancy ; Prenatal Exposure Delayed Effects ; Pyruvaldehyde - toxicity</subject><ispartof>Nutrition reviews, 2021-01, Vol.79 (1), p.13-24</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-ff450b11d543a9e068ca35c104464ee440eeb58c889127306f8ded24d1207cb23</citedby><cites>FETCH-LOGICAL-c369t-ff450b11d543a9e068ca35c104464ee440eeb58c889127306f8ded24d1207cb23</cites><orcidid>0000-0003-0490-1212</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32951053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Francisco, Flávio A</creatorcontrib><creatorcontrib>Saavedra, Lucas P J</creatorcontrib><creatorcontrib>Junior, Marcos D F</creatorcontrib><creatorcontrib>Barra, Cátia</creatorcontrib><creatorcontrib>Matafome, Paulo</creatorcontrib><creatorcontrib>Mathias, Paulo C F</creatorcontrib><creatorcontrib>Gomes, Rodrigo M</creatorcontrib><title>Early AGEing and metabolic diseases: is perinatal exposure to glycotoxins programming for adult-life metabolic syndrome?</title><title>Nutrition reviews</title><addtitle>Nutr Rev</addtitle><description>Abstract
Perinatal early nutritional disorders are critical for the developmental origins of health and disease. Glycotoxins, or advanced glycation end-products, and their precursors such as the methylglyoxal, which are formed endogenously and commonly found in processed foods and infant formulas, may be associated with acute and long-term metabolic disorders. Besides general aspects of glycotoxins, such as their endogenous production, exogenous sources, and their role in the development of metabolic syndrome, we discuss in this review the sources of perinatal exposure to glycotoxins and their involvement in metabolic programming mechanisms. The role of perinatal glycotoxin exposure in the onset of insulin resistance, central nervous system development, cardiovascular diseases, and early aging also are discussed, as are possible interventions that may prevent or reduce such effects.</description><subject>Aging</subject><subject>Animals</subject><subject>Female</subject><subject>Fetus</subject><subject>Glycation End Products, Advanced - metabolism</subject><subject>Glycation End Products, Advanced - toxicity</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Insulin Resistance</subject><subject>Metabolic Syndrome - etiology</subject><subject>Metabolic Syndrome - metabolism</subject><subject>Metabolic Syndrome - physiopathology</subject><subject>Oxidative Stress</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Pyruvaldehyde - toxicity</subject><issn>0029-6643</issn><issn>1753-4887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAURi0EgvJYGZFHGFKuY-fFgqqqPCQkFpgjx76pjJy42I7U_HuCWhAb07ece3R1CLlkMGdQ8dt-iN7EaaSEQhyQGSsynoiyLA7JDCCtkjwX_ISchvABACyt-DE54WmVMcj4jGxX0tuRLh5Xpl9T2WvaYZSNs0ZRbQLKgOGOmkA36E0vo7QUtxsXBo80Orq2o3LRbU0_Ed6tvey6b1HrPJV6sDGxpsU_zjD22rsO78_JUSttwIv9npH3h9Xb8il5eX18Xi5eEsXzKiZtKzJoGNOZ4LJCyEsleaYYCJELRCEAsclKVZYVSwsOeVtq1KnQLIVCNSk_I9c77_Te54Ah1p0JCq2VPboh1KmYTJBXUE7ofIcq70Lw2NYbbzrpx5pB_V273tWu97Wng6u9e2g61L_4T94JuNkBbtj8J_sCMiON-Q</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Francisco, Flávio A</creator><creator>Saavedra, Lucas P J</creator><creator>Junior, Marcos D F</creator><creator>Barra, Cátia</creator><creator>Matafome, Paulo</creator><creator>Mathias, Paulo C F</creator><creator>Gomes, Rodrigo M</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0490-1212</orcidid></search><sort><creationdate>20210101</creationdate><title>Early AGEing and metabolic diseases: is perinatal exposure to glycotoxins programming for adult-life metabolic syndrome?</title><author>Francisco, Flávio A ; Saavedra, Lucas P J ; Junior, Marcos D F ; Barra, Cátia ; Matafome, Paulo ; Mathias, Paulo C F ; Gomes, Rodrigo M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-ff450b11d543a9e068ca35c104464ee440eeb58c889127306f8ded24d1207cb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Female</topic><topic>Fetus</topic><topic>Glycation End Products, Advanced - metabolism</topic><topic>Glycation End Products, Advanced - toxicity</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Insulin Resistance</topic><topic>Metabolic Syndrome - etiology</topic><topic>Metabolic Syndrome - metabolism</topic><topic>Metabolic Syndrome - physiopathology</topic><topic>Oxidative Stress</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Pyruvaldehyde - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Francisco, Flávio A</creatorcontrib><creatorcontrib>Saavedra, Lucas P J</creatorcontrib><creatorcontrib>Junior, Marcos D F</creatorcontrib><creatorcontrib>Barra, Cátia</creatorcontrib><creatorcontrib>Matafome, Paulo</creatorcontrib><creatorcontrib>Mathias, Paulo C F</creatorcontrib><creatorcontrib>Gomes, Rodrigo M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Francisco, Flávio A</au><au>Saavedra, Lucas P J</au><au>Junior, Marcos D F</au><au>Barra, Cátia</au><au>Matafome, Paulo</au><au>Mathias, Paulo C F</au><au>Gomes, Rodrigo M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early AGEing and metabolic diseases: is perinatal exposure to glycotoxins programming for adult-life metabolic syndrome?</atitle><jtitle>Nutrition reviews</jtitle><addtitle>Nutr Rev</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>79</volume><issue>1</issue><spage>13</spage><epage>24</epage><pages>13-24</pages><issn>0029-6643</issn><eissn>1753-4887</eissn><abstract>Abstract
Perinatal early nutritional disorders are critical for the developmental origins of health and disease. Glycotoxins, or advanced glycation end-products, and their precursors such as the methylglyoxal, which are formed endogenously and commonly found in processed foods and infant formulas, may be associated with acute and long-term metabolic disorders. Besides general aspects of glycotoxins, such as their endogenous production, exogenous sources, and their role in the development of metabolic syndrome, we discuss in this review the sources of perinatal exposure to glycotoxins and their involvement in metabolic programming mechanisms. The role of perinatal glycotoxin exposure in the onset of insulin resistance, central nervous system development, cardiovascular diseases, and early aging also are discussed, as are possible interventions that may prevent or reduce such effects.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>32951053</pmid><doi>10.1093/nutrit/nuaa074</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-0490-1212</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrition reviews, 2021-01, Vol.79 (1), p.13-24 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Aging Animals Female Fetus Glycation End Products, Advanced - metabolism Glycation End Products, Advanced - toxicity Humans Infant Infant, Newborn Insulin Resistance Metabolic Syndrome - etiology Metabolic Syndrome - metabolism Metabolic Syndrome - physiopathology Oxidative Stress Pregnancy Prenatal Exposure Delayed Effects Pyruvaldehyde - toxicity |
| title | Early AGEing and metabolic diseases: is perinatal exposure to glycotoxins programming for adult-life metabolic syndrome? |
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