Hypoglycemia increases endothelial-dependent vasodilation through suppressing phosphorylation at Threonine 495/497 site of endothelial nitric oxide synthase

Phosphorylation plays an essential role in the regulation of endothelial nitric oxide synthase (eNOS) activity. However, the phosphorylation of eNOS under hypoglycemia and whether hypoglycemia changes eNOS activity is unknown. This paper aims to clarify the regulation of eNOS phosphorylation and its...

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Veröffentlicht in:	Microvascular research 2021-01, Vol.133, p.104075-104075, Article 104075
Hauptverfasser:	He, An, Zuo, Deyu, Liang, Xiaoxue, Guo, Yongzheng, Suxin, Luo, Xia, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Aorta, Thoracic - enzymology Aorta, Thoracic - physiopathology Blood Glucose - metabolism Cattle Cells, Cultured Disease Models, Animal Endothelial Cells - enzymology Endothelium-dependent vasodilation eNOS phosphorylation Female Hypoglycemia Hypoglycemia - enzymology Hypoglycemia - physiopathology Male Mesenteric Arteries - enzymology Mesenteric Arteries - physiopathology Nitric Oxide - blood Nitric Oxide Synthase Type III - metabolism Phosphorylation Protein Kinase C-alpha - genetics Protein Kinase C-alpha - metabolism Rats Rats, Sprague-Dawley Signal Transduction Vasodilation
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