rOmpF and OMVs as efficient subunit vaccines against Salmonella enterica serovar Enteritidis infections in poultry farms
•rOmpF produced higher protective efficacy than rOmpC in chickens.•QuilA and OMVs were proved to be better adjuvants than the others used in rOmpF.•rOmpF plus QuilA or OMVs alone induced strong cellular immune response in spleen.•The developed subunit vaccines could clear S. Enteritidis rapidly in c...
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| Veröffentlicht in: | Vaccine 2020-10, Vol.38 (45), p.7094-7099 |
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| creator | Li, Qiuchun Ren, Jingwei Xian, Honghong Yin, Chao Yuan, Yu Li, Yang Ji, Ruoyun Chu, Chao Qiao, Zhuang Jiao, Xinan |
| description | •rOmpF produced higher protective efficacy than rOmpC in chickens.•QuilA and OMVs were proved to be better adjuvants than the others used in rOmpF.•rOmpF plus QuilA or OMVs alone induced strong cellular immune response in spleen.•The developed subunit vaccines could clear S. Enteritidis rapidly in chicken tissues.
Salmonella enterica serovar Enteritidis remains the most prevalent serotype causing human salmonellosis through the consumption of contaminated foods, especially poultry products. The development of a subunit vaccine against S. Enteritidis can not only protect chickens against Salmonella infection in the poultry industry but also cut the transmission sources. In this study, both the expressed recombinant outer membrane protein F (rOmpF) and extracted outer membrane vesicles (OMVs) were developed as subunit vaccines against S. Enteritidis challenge in chickens. Immunization with the subunit vaccine could induce not only antibody production but also strong cell-mediated immune response. Both rOmpF plus QuilA adjuvant and OMVs alone had highly protective efficacy against S. Enteritidis challenge and rapidly decreased the colonization of bacteria in chicken. These findings revealed the potential application of rOmpF and OMVs as subunit vaccines in the poultry industry. |
| doi_str_mv | 10.1016/j.vaccine.2020.08.074 |
| format | Article |
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Salmonella enterica serovar Enteritidis remains the most prevalent serotype causing human salmonellosis through the consumption of contaminated foods, especially poultry products. The development of a subunit vaccine against S. Enteritidis can not only protect chickens against Salmonella infection in the poultry industry but also cut the transmission sources. In this study, both the expressed recombinant outer membrane protein F (rOmpF) and extracted outer membrane vesicles (OMVs) were developed as subunit vaccines against S. Enteritidis challenge in chickens. Immunization with the subunit vaccine could induce not only antibody production but also strong cell-mediated immune response. Both rOmpF plus QuilA adjuvant and OMVs alone had highly protective efficacy against S. Enteritidis challenge and rapidly decreased the colonization of bacteria in chicken. These findings revealed the potential application of rOmpF and OMVs as subunit vaccines in the poultry industry.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2020.08.074</identifier><identifier>PMID: 32951940</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; Antibodies ; Antigens ; Chickens ; Colonization ; Cytokines ; Efficiency ; Experiments ; Farms ; Food consumption ; Food contamination ; Food contamination & poisoning ; Humans ; Immune response ; Immune response (cell-mediated) ; Immune system ; Immunization ; Infections ; Laboratory animals ; Membrane proteins ; Membrane vesicles ; Membranes ; OmpC ; OmpF ; Outer membrane vesicles (OMVs) ; Pathogens ; Porins ; Poultry ; Poultry Diseases - prevention & control ; Poultry farming ; Proteins ; Salmonella ; Salmonella enterica ; Salmonella enterica serovar Enteritidis (S. Enteritidis) ; Salmonella enteritidis ; Salmonella Infections, Animal - prevention & control ; Salmonella Vaccines ; Salmonellosis ; Spleen ; Subunit vaccine ; Vaccines ; Vaccines, Subunit</subject><ispartof>Vaccine, 2020-10, Vol.38 (45), p.7094-7099</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><rights>2020. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-48fa1595f97498f831c48d3375a893cc25db41c22f6e06bff643913c184703f83</citedby><cites>FETCH-LOGICAL-c393t-48fa1595f97498f831c48d3375a893cc25db41c22f6e06bff643913c184703f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2448624075?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32951940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Qiuchun</creatorcontrib><creatorcontrib>Ren, Jingwei</creatorcontrib><creatorcontrib>Xian, Honghong</creatorcontrib><creatorcontrib>Yin, Chao</creatorcontrib><creatorcontrib>Yuan, Yu</creatorcontrib><creatorcontrib>Li, Yang</creatorcontrib><creatorcontrib>Ji, Ruoyun</creatorcontrib><creatorcontrib>Chu, Chao</creatorcontrib><creatorcontrib>Qiao, Zhuang</creatorcontrib><creatorcontrib>Jiao, Xinan</creatorcontrib><title>rOmpF and OMVs as efficient subunit vaccines against Salmonella enterica serovar Enteritidis infections in poultry farms</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>•rOmpF produced higher protective efficacy than rOmpC in chickens.•QuilA and OMVs were proved to be better adjuvants than the others used in rOmpF.•rOmpF plus QuilA or OMVs alone induced strong cellular immune response in spleen.•The developed subunit vaccines could clear S. Enteritidis rapidly in chicken tissues.
Salmonella enterica serovar Enteritidis remains the most prevalent serotype causing human salmonellosis through the consumption of contaminated foods, especially poultry products. The development of a subunit vaccine against S. Enteritidis can not only protect chickens against Salmonella infection in the poultry industry but also cut the transmission sources. In this study, both the expressed recombinant outer membrane protein F (rOmpF) and extracted outer membrane vesicles (OMVs) were developed as subunit vaccines against S. Enteritidis challenge in chickens. Immunization with the subunit vaccine could induce not only antibody production but also strong cell-mediated immune response. Both rOmpF plus QuilA adjuvant and OMVs alone had highly protective efficacy against S. Enteritidis challenge and rapidly decreased the colonization of bacteria in chicken. These findings revealed the potential application of rOmpF and OMVs as subunit vaccines in the poultry industry.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Chickens</subject><subject>Colonization</subject><subject>Cytokines</subject><subject>Efficiency</subject><subject>Experiments</subject><subject>Farms</subject><subject>Food consumption</subject><subject>Food contamination</subject><subject>Food contamination & poisoning</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune response (cell-mediated)</subject><subject>Immune system</subject><subject>Immunization</subject><subject>Infections</subject><subject>Laboratory animals</subject><subject>Membrane proteins</subject><subject>Membrane vesicles</subject><subject>Membranes</subject><subject>OmpC</subject><subject>OmpF</subject><subject>Outer membrane vesicles (OMVs)</subject><subject>Pathogens</subject><subject>Porins</subject><subject>Poultry</subject><subject>Poultry Diseases - prevention & control</subject><subject>Poultry farming</subject><subject>Proteins</subject><subject>Salmonella</subject><subject>Salmonella enterica</subject><subject>Salmonella enterica serovar Enteritidis (S. Enteritidis)</subject><subject>Salmonella enteritidis</subject><subject>Salmonella Infections, Animal - prevention & control</subject><subject>Salmonella Vaccines</subject><subject>Salmonellosis</subject><subject>Spleen</subject><subject>Subunit vaccine</subject><subject>Vaccines</subject><subject>Vaccines, Subunit</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUuPFCEURonROD2jP0FD4sZNlZdXFayMmcw4JmN64SPuCE2BoVMFLVR1nH8vZbcu3LiCwLmPfAehFwRaAqR7s2-PxtoQXUuBQguyhZ4_Qhsie9ZQQeRjtAHa8YYT-HaBLkvZA4BgRD1FF4wqQRSHDfqZt9PhFps44O3HrwWbgp33wQYXZ1yW3RLDjM-T6u93E2KZ8SczTim6cTS4ci4Ha3BxOR1Nxje_H-YwhIJD9M7OIcX1ig9pGef8gL3JU3mGnngzFvf8fF6hL7c3n6_vmvvt-w_X7-4byxSbGy69IUIJr3qupJeMWC4HxnphpGLWUjHsOLGU-s5Bt_O-40wRZonkPbDKX6HXp76HnH4srsx6CsWuq0eXlqIp57wDxgVU9NU_6D4tOdbtVkp2lEMvKiVOlM2plOy8PuQwmfygCehVjd7rc2B6VaNB6qqm1r08d192kxv-Vv1xUYG3J8DVOI7BZV1WDdYNIdcU9ZDCf0b8AvZNoqM</recordid><startdate>20201021</startdate><enddate>20201021</enddate><creator>Li, Qiuchun</creator><creator>Ren, Jingwei</creator><creator>Xian, Honghong</creator><creator>Yin, Chao</creator><creator>Yuan, Yu</creator><creator>Li, Yang</creator><creator>Ji, Ruoyun</creator><creator>Chu, Chao</creator><creator>Qiao, Zhuang</creator><creator>Jiao, Xinan</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20201021</creationdate><title>rOmpF and OMVs as efficient subunit vaccines against Salmonella enterica serovar Enteritidis infections in poultry farms</title><author>Li, Qiuchun ; Ren, Jingwei ; Xian, Honghong ; Yin, Chao ; Yuan, Yu ; Li, Yang ; Ji, Ruoyun ; Chu, Chao ; Qiao, Zhuang ; Jiao, Xinan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-48fa1595f97498f831c48d3375a893cc25db41c22f6e06bff643913c184703f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>Chickens</topic><topic>Colonization</topic><topic>Cytokines</topic><topic>Efficiency</topic><topic>Experiments</topic><topic>Farms</topic><topic>Food consumption</topic><topic>Food contamination</topic><topic>Food contamination & poisoning</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune response (cell-mediated)</topic><topic>Immune system</topic><topic>Immunization</topic><topic>Infections</topic><topic>Laboratory animals</topic><topic>Membrane proteins</topic><topic>Membrane vesicles</topic><topic>Membranes</topic><topic>OmpC</topic><topic>OmpF</topic><topic>Outer membrane vesicles (OMVs)</topic><topic>Pathogens</topic><topic>Porins</topic><topic>Poultry</topic><topic>Poultry Diseases - prevention & control</topic><topic>Poultry farming</topic><topic>Proteins</topic><topic>Salmonella</topic><topic>Salmonella enterica</topic><topic>Salmonella enterica serovar Enteritidis (S. Enteritidis)</topic><topic>Salmonella enteritidis</topic><topic>Salmonella Infections, Animal - prevention & control</topic><topic>Salmonella Vaccines</topic><topic>Salmonellosis</topic><topic>Spleen</topic><topic>Subunit vaccine</topic><topic>Vaccines</topic><topic>Vaccines, Subunit</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Qiuchun</creatorcontrib><creatorcontrib>Ren, Jingwei</creatorcontrib><creatorcontrib>Xian, Honghong</creatorcontrib><creatorcontrib>Yin, Chao</creatorcontrib><creatorcontrib>Yuan, Yu</creatorcontrib><creatorcontrib>Li, Yang</creatorcontrib><creatorcontrib>Ji, Ruoyun</creatorcontrib><creatorcontrib>Chu, Chao</creatorcontrib><creatorcontrib>Qiao, Zhuang</creatorcontrib><creatorcontrib>Jiao, Xinan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Qiuchun</au><au>Ren, Jingwei</au><au>Xian, Honghong</au><au>Yin, Chao</au><au>Yuan, Yu</au><au>Li, Yang</au><au>Ji, Ruoyun</au><au>Chu, Chao</au><au>Qiao, Zhuang</au><au>Jiao, Xinan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>rOmpF and OMVs as efficient subunit vaccines against Salmonella enterica serovar Enteritidis infections in poultry farms</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2020-10-21</date><risdate>2020</risdate><volume>38</volume><issue>45</issue><spage>7094</spage><epage>7099</epage><pages>7094-7099</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>•rOmpF produced higher protective efficacy than rOmpC in chickens.•QuilA and OMVs were proved to be better adjuvants than the others used in rOmpF.•rOmpF plus QuilA or OMVs alone induced strong cellular immune response in spleen.•The developed subunit vaccines could clear S. Enteritidis rapidly in chicken tissues.
Salmonella enterica serovar Enteritidis remains the most prevalent serotype causing human salmonellosis through the consumption of contaminated foods, especially poultry products. The development of a subunit vaccine against S. Enteritidis can not only protect chickens against Salmonella infection in the poultry industry but also cut the transmission sources. In this study, both the expressed recombinant outer membrane protein F (rOmpF) and extracted outer membrane vesicles (OMVs) were developed as subunit vaccines against S. Enteritidis challenge in chickens. Immunization with the subunit vaccine could induce not only antibody production but also strong cell-mediated immune response. Both rOmpF plus QuilA adjuvant and OMVs alone had highly protective efficacy against S. Enteritidis challenge and rapidly decreased the colonization of bacteria in chicken. These findings revealed the potential application of rOmpF and OMVs as subunit vaccines in the poultry industry.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>32951940</pmid><doi>10.1016/j.vaccine.2020.08.074</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Antibodies Antigens Chickens Colonization Cytokines Efficiency Experiments Farms Food consumption Food contamination Food contamination & poisoning Humans Immune response Immune response (cell-mediated) Immune system Immunization Infections Laboratory animals Membrane proteins Membrane vesicles Membranes OmpC OmpF Outer membrane vesicles (OMVs) Pathogens Porins Poultry Poultry Diseases - prevention & control Poultry farming Proteins Salmonella Salmonella enterica Salmonella enterica serovar Enteritidis (S. Enteritidis) Salmonella enteritidis Salmonella Infections, Animal - prevention & control Salmonella Vaccines Salmonellosis Spleen Subunit vaccine Vaccines Vaccines, Subunit |
| title | rOmpF and OMVs as efficient subunit vaccines against Salmonella enterica serovar Enteritidis infections in poultry farms |
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