Clinical observation on the effect of Chinese medicine-“TCM formula” intervention on recurrence and metastasis of triple negative breast cancer
•This study used a prospective cohort study to observe the effect of triple-negative breast cancer on the 2-year disease-free survival rate with or without “TCM Formula”.•Through K-–M survival analysis, TNBC patients with age ≤35 years and regional lymph node stage N1 may be the benefit group of “TC...
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| creator | Wang, Yi Li, Jian-Wei Qin, Yue-Nong Sun, Chen-Ping Chen, Jia-Jing Ruan, Yi-Ying Chen, Li-Xin Liu, Sheng Liu, Guang-Yu |
| description | •This study used a prospective cohort study to observe the effect of triple-negative breast cancer on the 2-year disease-free survival rate with or without “TCM Formula”.•Through K-–M survival analysis, TNBC patients with age ≤35 years and regional lymph node stage N1 may be the benefit group of “TCM Formula”(P |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2444603448</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0965229919313871</els_id><sourcerecordid>2444603448</sourcerecordid><originalsourceid>FETCH-LOGICAL-c428t-7ed51a5202f1d4c39527cbcfb17f132baf4a7dff757bdfc51d3bfc8dadd134423</originalsourceid><addsrcrecordid>eNp9kU-OFCEYxYnROO3oBVwYEjduquVfFV2JG1PR0WSMm3FNKPhw6FRBC1Qn7uYOs9XLzUmk0jMuXJiQQOD3HvAeQi8p2VJCu7f7rSl-3jLC1g0m2u4R2tCd5E3Xd_wx2pC-axvG-v4MPct5TwjpueRP0RlnfUsllRt0O0w-eKMnHMcM6aiLjwHXUa4Bg3NgCo4OD9c-QAY8g_WmLpu7m19XwxfsYpqXSd_d_MY-lKqH8GCQwCwpQTCAdbBVWXSuw-fVryR_mAAH-F4vPAIeE9RTbHTF03P0xOkpw4v7-Rx9-_jhavjUXH69-Dy8v2yMYLvSSLAt1W39vqNWGN63TJrRuJFKRzkbtRNaWudkK0frTEstH53ZWW0t5UIwfo7enHwPKf5YIBc1-2xgmnSAuGTFhBAdqeiuoq__QfdxSaG-bqW4kD3tZaXYiTIp5pzAqUPys04_FSVqrUzt1VqZWitTp8qq6NW99TLWeP9KHjqqwLsTADWLo4eksvFrrtbXjIuy0f_P_w9KKaxt</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2443479197</pqid></control><display><type>article</type><title>Clinical observation on the effect of Chinese medicine-“TCM formula” intervention on recurrence and metastasis of triple negative breast cancer</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Wang, Yi ; Li, Jian-Wei ; Qin, Yue-Nong ; Sun, Chen-Ping ; Chen, Jia-Jing ; Ruan, Yi-Ying ; Chen, Li-Xin ; Liu, Sheng ; Liu, Guang-Yu</creator><creatorcontrib>Wang, Yi ; Li, Jian-Wei ; Qin, Yue-Nong ; Sun, Chen-Ping ; Chen, Jia-Jing ; Ruan, Yi-Ying ; Chen, Li-Xin ; Liu, Sheng ; Liu, Guang-Yu</creatorcontrib><description>•This study used a prospective cohort study to observe the effect of triple-negative breast cancer on the 2-year disease-free survival rate with or without “TCM Formula”.•Through K-–M survival analysis, TNBC patients with age ≤35 years and regional lymph node stage N1 may be the benefit group of “TCM Formula”(P < 0.05).•Logistic multivariate regression analysis predicted that “TCM Formula” could reduce the disease-related recurrence and metastasis rate by 11% (OR=0.89, 95 % CI 0.37−0.956, P < 0.05).
This study used a prospective cohort study to observe the effect of triple-negative breast cancer on the 2-year disease-free survival rate with or without “TCM formula”.
From November 1 st, 2016, the first patient was enrolled in the cohort study. A total of 356 patients were enrolled on January 30, 2019. Among them, 154 cases were followed up for 2 years. During the follow-up, there were 6 cases of shedding, so 6 cases were affected. A total of 148 cases were included in the analysis, including 73 in the exposed group and 75 in the non-exposed group. The exposed group was given “TCM formula” on the basis of standardized treatment, and the non-exposed group was treated with simple triple-negative breast cancer. The two groups visited each of the three months. The interview included safety examination (hematology and imaging). The endpoint was the difference in 2-year invasive disease-free survival between the exposed and non-exposed groups and the safety of the “TCM formula”.
There were 6 cases of shedding during the experiment and the shedding rate was 3.9 %. The 2-year rate of invasive disease-free survival in the exposed team was 88.7 % and the non-exposed group was 82.5 %. Logistic multivariate regression analysis predicted that “TCM formula” could reduce the disease-related recurrence and metastasis rate by 11 % (OR = 0.89, 95 % CI 0.37−0.956, P＜0.05). Through K–M survival analysis, TNBC patients with age ≤35 years and regional lymph node stage N1 may be the benefit group of “TCM formula”(P＜0.05). During the study, the incidence of total adverse events was 8.2 % in the exposed group, mainly manifested as stomach discomfort, diarrhea, and hepatocyte damage.
1. In the exposed group, the two-year rate of invasive disease-free survival increased by 6.2 % compared with the non-exposed group(P＞0.05). 2. According to K–M survival analysis, TNBC patients with age ≤35 years and regional lymph node metastasis to N1 may be potential beneficiaries of “TCM formula”. 3. “TCM Formula” is safe and tolerable to most patients.</description><identifier>ISSN: 0965-2299</identifier><identifier>EISSN: 1873-6963</identifier><identifier>DOI: 10.1016/j.ctim.2020.102456</identifier><identifier>PMID: 32951717</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Adult ; Aged ; Androgens ; Breast cancer ; Cancer therapies ; Chemotherapy ; Chinese medicine ; Clinical trail ; Cohort analysis ; Cohort Studies ; Cohort study ; Data analysis ; Diarrhea ; Disease-Free Survival ; Exposure ; Female ; Hematology ; Herbal medicine ; Hospitals ; Humans ; Invasiveness ; Lymph nodes ; Medicine, Chinese Traditional - methods ; Metastases ; Metastasis ; Middle Aged ; Neoplasm Metastasis - drug therapy ; Neoplasm Recurrence, Local - drug therapy ; Neoplasm Recurrence, Local - mortality ; Patients ; Prospective Studies ; Radiation therapy ; Regression analysis ; Shedding ; Surgery ; Survival ; Survival Analysis ; TCM formula ; Triple Negative Breast Neoplasms - drug therapy ; Triple Negative Breast Neoplasms - mortality ; Triple-negative breast cancer</subject><ispartof>Complementary therapies in medicine, 2020-08, Vol.52, p.102456-102456, Article 102456</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><rights>2020. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-7ed51a5202f1d4c39527cbcfb17f132baf4a7dff757bdfc51d3bfc8dadd134423</citedby><cites>FETCH-LOGICAL-c428t-7ed51a5202f1d4c39527cbcfb17f132baf4a7dff757bdfc51d3bfc8dadd134423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0965229919313871$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32951717$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Li, Jian-Wei</creatorcontrib><creatorcontrib>Qin, Yue-Nong</creatorcontrib><creatorcontrib>Sun, Chen-Ping</creatorcontrib><creatorcontrib>Chen, Jia-Jing</creatorcontrib><creatorcontrib>Ruan, Yi-Ying</creatorcontrib><creatorcontrib>Chen, Li-Xin</creatorcontrib><creatorcontrib>Liu, Sheng</creatorcontrib><creatorcontrib>Liu, Guang-Yu</creatorcontrib><title>Clinical observation on the effect of Chinese medicine-“TCM formula” intervention on recurrence and metastasis of triple negative breast cancer</title><title>Complementary therapies in medicine</title><addtitle>Complement Ther Med</addtitle><description>•This study used a prospective cohort study to observe the effect of triple-negative breast cancer on the 2-year disease-free survival rate with or without “TCM Formula”.•Through K-–M survival analysis, TNBC patients with age ≤35 years and regional lymph node stage N1 may be the benefit group of “TCM Formula”(P < 0.05).•Logistic multivariate regression analysis predicted that “TCM Formula” could reduce the disease-related recurrence and metastasis rate by 11% (OR=0.89, 95 % CI 0.37−0.956, P < 0.05).
This study used a prospective cohort study to observe the effect of triple-negative breast cancer on the 2-year disease-free survival rate with or without “TCM formula”.
From November 1 st, 2016, the first patient was enrolled in the cohort study. A total of 356 patients were enrolled on January 30, 2019. Among them, 154 cases were followed up for 2 years. During the follow-up, there were 6 cases of shedding, so 6 cases were affected. A total of 148 cases were included in the analysis, including 73 in the exposed group and 75 in the non-exposed group. The exposed group was given “TCM formula” on the basis of standardized treatment, and the non-exposed group was treated with simple triple-negative breast cancer. The two groups visited each of the three months. The interview included safety examination (hematology and imaging). The endpoint was the difference in 2-year invasive disease-free survival between the exposed and non-exposed groups and the safety of the “TCM formula”.
There were 6 cases of shedding during the experiment and the shedding rate was 3.9 %. The 2-year rate of invasive disease-free survival in the exposed team was 88.7 % and the non-exposed group was 82.5 %. Logistic multivariate regression analysis predicted that “TCM formula” could reduce the disease-related recurrence and metastasis rate by 11 % (OR = 0.89, 95 % CI 0.37−0.956, P＜0.05). Through K–M survival analysis, TNBC patients with age ≤35 years and regional lymph node stage N1 may be the benefit group of “TCM formula”(P＜0.05). During the study, the incidence of total adverse events was 8.2 % in the exposed group, mainly manifested as stomach discomfort, diarrhea, and hepatocyte damage.
1. In the exposed group, the two-year rate of invasive disease-free survival increased by 6.2 % compared with the non-exposed group(P＞0.05). 2. According to K–M survival analysis, TNBC patients with age ≤35 years and regional lymph node metastasis to N1 may be potential beneficiaries of “TCM formula”. 3. “TCM Formula” is safe and tolerable to most patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Androgens</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Chinese medicine</subject><subject>Clinical trail</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Cohort study</subject><subject>Data analysis</subject><subject>Diarrhea</subject><subject>Disease-Free Survival</subject><subject>Exposure</subject><subject>Female</subject><subject>Hematology</subject><subject>Herbal medicine</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Invasiveness</subject><subject>Lymph nodes</subject><subject>Medicine, Chinese Traditional - methods</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis - drug therapy</subject><subject>Neoplasm Recurrence, Local - drug therapy</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Patients</subject><subject>Prospective Studies</subject><subject>Radiation therapy</subject><subject>Regression analysis</subject><subject>Shedding</subject><subject>Surgery</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>TCM formula</subject><subject>Triple Negative Breast Neoplasms - drug therapy</subject><subject>Triple Negative Breast Neoplasms - mortality</subject><subject>Triple-negative breast cancer</subject><issn>0965-2299</issn><issn>1873-6963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU-OFCEYxYnROO3oBVwYEjduquVfFV2JG1PR0WSMm3FNKPhw6FRBC1Qn7uYOs9XLzUmk0jMuXJiQQOD3HvAeQi8p2VJCu7f7rSl-3jLC1g0m2u4R2tCd5E3Xd_wx2pC-axvG-v4MPct5TwjpueRP0RlnfUsllRt0O0w-eKMnHMcM6aiLjwHXUa4Bg3NgCo4OD9c-QAY8g_WmLpu7m19XwxfsYpqXSd_d_MY-lKqH8GCQwCwpQTCAdbBVWXSuw-fVryR_mAAH-F4vPAIeE9RTbHTF03P0xOkpw4v7-Rx9-_jhavjUXH69-Dy8v2yMYLvSSLAt1W39vqNWGN63TJrRuJFKRzkbtRNaWudkK0frTEstH53ZWW0t5UIwfo7enHwPKf5YIBc1-2xgmnSAuGTFhBAdqeiuoq__QfdxSaG-bqW4kD3tZaXYiTIp5pzAqUPys04_FSVqrUzt1VqZWitTp8qq6NW99TLWeP9KHjqqwLsTADWLo4eksvFrrtbXjIuy0f_P_w9KKaxt</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Wang, Yi</creator><creator>Li, Jian-Wei</creator><creator>Qin, Yue-Nong</creator><creator>Sun, Chen-Ping</creator><creator>Chen, Jia-Jing</creator><creator>Ruan, Yi-Ying</creator><creator>Chen, Li-Xin</creator><creator>Liu, Sheng</creator><creator>Liu, Guang-Yu</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>202008</creationdate><title>Clinical observation on the effect of Chinese medicine-“TCM formula” intervention on recurrence and metastasis of triple negative breast cancer</title><author>Wang, Yi ; Li, Jian-Wei ; Qin, Yue-Nong ; Sun, Chen-Ping ; Chen, Jia-Jing ; Ruan, Yi-Ying ; Chen, Li-Xin ; Liu, Sheng ; Liu, Guang-Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-7ed51a5202f1d4c39527cbcfb17f132baf4a7dff757bdfc51d3bfc8dadd134423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Androgens</topic><topic>Breast cancer</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Chinese medicine</topic><topic>Clinical trail</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Cohort study</topic><topic>Data analysis</topic><topic>Diarrhea</topic><topic>Disease-Free Survival</topic><topic>Exposure</topic><topic>Female</topic><topic>Hematology</topic><topic>Herbal medicine</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Invasiveness</topic><topic>Lymph nodes</topic><topic>Medicine, Chinese Traditional - methods</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis - drug therapy</topic><topic>Neoplasm Recurrence, Local - drug therapy</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Patients</topic><topic>Prospective Studies</topic><topic>Radiation therapy</topic><topic>Regression analysis</topic><topic>Shedding</topic><topic>Surgery</topic><topic>Survival</topic><topic>Survival Analysis</topic><topic>TCM formula</topic><topic>Triple Negative Breast Neoplasms - drug therapy</topic><topic>Triple Negative Breast Neoplasms - mortality</topic><topic>Triple-negative breast cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yi</creatorcontrib><creatorcontrib>Li, Jian-Wei</creatorcontrib><creatorcontrib>Qin, Yue-Nong</creatorcontrib><creatorcontrib>Sun, Chen-Ping</creatorcontrib><creatorcontrib>Chen, Jia-Jing</creatorcontrib><creatorcontrib>Ruan, Yi-Ying</creatorcontrib><creatorcontrib>Chen, Li-Xin</creatorcontrib><creatorcontrib>Liu, Sheng</creatorcontrib><creatorcontrib>Liu, Guang-Yu</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Complementary therapies in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yi</au><au>Li, Jian-Wei</au><au>Qin, Yue-Nong</au><au>Sun, Chen-Ping</au><au>Chen, Jia-Jing</au><au>Ruan, Yi-Ying</au><au>Chen, Li-Xin</au><au>Liu, Sheng</au><au>Liu, Guang-Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical observation on the effect of Chinese medicine-“TCM formula” intervention on recurrence and metastasis of triple negative breast cancer</atitle><jtitle>Complementary therapies in medicine</jtitle><addtitle>Complement Ther Med</addtitle><date>2020-08</date><risdate>2020</risdate><volume>52</volume><spage>102456</spage><epage>102456</epage><pages>102456-102456</pages><artnum>102456</artnum><issn>0965-2299</issn><eissn>1873-6963</eissn><abstract>•This study used a prospective cohort study to observe the effect of triple-negative breast cancer on the 2-year disease-free survival rate with or without “TCM Formula”.•Through K-–M survival analysis, TNBC patients with age ≤35 years and regional lymph node stage N1 may be the benefit group of “TCM Formula”(P < 0.05).•Logistic multivariate regression analysis predicted that “TCM Formula” could reduce the disease-related recurrence and metastasis rate by 11% (OR=0.89, 95 % CI 0.37−0.956, P < 0.05).
This study used a prospective cohort study to observe the effect of triple-negative breast cancer on the 2-year disease-free survival rate with or without “TCM formula”.
From November 1 st, 2016, the first patient was enrolled in the cohort study. A total of 356 patients were enrolled on January 30, 2019. Among them, 154 cases were followed up for 2 years. During the follow-up, there were 6 cases of shedding, so 6 cases were affected. A total of 148 cases were included in the analysis, including 73 in the exposed group and 75 in the non-exposed group. The exposed group was given “TCM formula” on the basis of standardized treatment, and the non-exposed group was treated with simple triple-negative breast cancer. The two groups visited each of the three months. The interview included safety examination (hematology and imaging). The endpoint was the difference in 2-year invasive disease-free survival between the exposed and non-exposed groups and the safety of the “TCM formula”.
There were 6 cases of shedding during the experiment and the shedding rate was 3.9 %. The 2-year rate of invasive disease-free survival in the exposed team was 88.7 % and the non-exposed group was 82.5 %. Logistic multivariate regression analysis predicted that “TCM formula” could reduce the disease-related recurrence and metastasis rate by 11 % (OR = 0.89, 95 % CI 0.37−0.956, P＜0.05). Through K–M survival analysis, TNBC patients with age ≤35 years and regional lymph node stage N1 may be the benefit group of “TCM formula”(P＜0.05). During the study, the incidence of total adverse events was 8.2 % in the exposed group, mainly manifested as stomach discomfort, diarrhea, and hepatocyte damage.
1. In the exposed group, the two-year rate of invasive disease-free survival increased by 6.2 % compared with the non-exposed group(P＞0.05). 2. According to K–M survival analysis, TNBC patients with age ≤35 years and regional lymph node metastasis to N1 may be potential beneficiaries of “TCM formula”. 3. “TCM Formula” is safe and tolerable to most patients.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>32951717</pmid><doi>10.1016/j.ctim.2020.102456</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Androgens Breast cancer Cancer therapies Chemotherapy Chinese medicine Clinical trail Cohort analysis Cohort Studies Cohort study Data analysis Diarrhea Disease-Free Survival Exposure Female Hematology Herbal medicine Hospitals Humans Invasiveness Lymph nodes Medicine, Chinese Traditional - methods Metastases Metastasis Middle Aged Neoplasm Metastasis - drug therapy Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - mortality Patients Prospective Studies Radiation therapy Regression analysis Shedding Surgery Survival Survival Analysis TCM formula Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - mortality Triple-negative breast cancer |
| title | Clinical observation on the effect of Chinese medicine-“TCM formula” intervention on recurrence and metastasis of triple negative breast cancer |
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