Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial
Objectives This study aimed to compare the effects of Passiflora incarnata , Erythrina mulungu , and midazolam in controlling anxiety in patients undergoing mandibular third molar extraction. Methods The volunteers underwent extraction of their third mandibular molars in a randomized, placebo-contro...
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| Veröffentlicht in: | Clinical oral investigations 2021-03, Vol.25 (3), p.1579-1586 |
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| creator | da Cunha, Rafael Soares Amorim, Klinger Souza Gercina, Anne Caroline de Oliveira, Allan Carlos Araújo dos Santos Menezes, Liciane Groppo, Francisco Carlos Souza, Liane Maciel Almeida |
| description | Objectives
This study aimed to compare the effects of
Passiflora incarnata
,
Erythrina mulungu
, and midazolam in controlling anxiety in patients undergoing mandibular third molar extraction.
Methods
The volunteers underwent extraction of their third mandibular molars in a randomized, placebo-controlled, triple-blind, and parallel clinical trial.
Passiflora incarnata
(500 mg),
Erythrina mulungu
(500 mg), or midazolam (15 mg) was orally administered 60 min before the surgery. The anxiety level of participants was evaluated using questionnaires and measurements of physical parameters, including heart rate (HR), blood pressure (BP), and oxygen saturation (SpO
2
).
Results
A total of 200 volunteers were included in this clinical trial. Considering each procedure independently, no significant differences (
p
> 0.05) in BP, HR, and SpO
2
were observed among the protocols.
Conclusions
Passiflora incarnata
showed a similar effect to midazolam but differed from placebo and mulungu, which were unable to control anxiety in this situation. Therefore, the results suggest that
Passiflora
configures an herbal medicine with an anxiolytic effect, adequate to use in third molar extractions.
Clinical relevance
The use of
Passiflora incarnata
may be an alternative to benzodiazepines for controlling anxiety in patients scheduled for oral surgery under local anesthesia.
Trial registration
ClinicalTrials.gov
: ANSI-388.427 |
| doi_str_mv | 10.1007/s00784-020-03468-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2444602665</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2488187426</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-9aec62c3a483cb6dc18ebcb2fbcfc27227f65273616173bded527442a030279d3</originalsourceid><addsrcrecordid>eNp9kc1LBCEYxiWKPrb-gQ4hdOkym1-rs8eIaoOgS53FcZzNxdFNHdj663M_KugQiL7i73leeR8AzjEaY4TEdSpbzSpEUIUo43WF98AxZpRXVAi8v6lJxac1PgInKS0QwowLegiOKJlOMCb4GCxnJjbKwd60VltvElRl-ZUN7iNbneAy2hBhDjC_2djCPjgVYRri3OoiM6sclc42-DG8gVH5NvT207RQB59jcG5dOus3cI5WuVNw0CmXzNnuHIHX-7uX21n19PzweHvzVGkqJrmaKqM50VSxmuqGtxrXptEN6RrdaSIIER2fEEE55ljQpjVtuTFGFKKIiGlLR-Bq67uM4X0wKcveJm2cU96EIUnCGOOIcD4p6OUfdBGG6MvvClXXuBaM8EKRLaVjSCmaTpbR9Cp-SIzkOg-5zUOWPOQmD4mL6GJnPTRlxD-S7wAKQLdAKk9-buJv739svwBwL5a7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2488187426</pqid></control><display><type>article</type><title>Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>da Cunha, Rafael Soares ; Amorim, Klinger Souza ; Gercina, Anne Caroline ; de Oliveira, Allan Carlos Araújo ; dos Santos Menezes, Liciane ; Groppo, Francisco Carlos ; Souza, Liane Maciel Almeida</creator><creatorcontrib>da Cunha, Rafael Soares ; Amorim, Klinger Souza ; Gercina, Anne Caroline ; de Oliveira, Allan Carlos Araújo ; dos Santos Menezes, Liciane ; Groppo, Francisco Carlos ; Souza, Liane Maciel Almeida</creatorcontrib><description>Objectives
This study aimed to compare the effects of
Passiflora incarnata
,
Erythrina mulungu
, and midazolam in controlling anxiety in patients undergoing mandibular third molar extraction.
Methods
The volunteers underwent extraction of their third mandibular molars in a randomized, placebo-controlled, triple-blind, and parallel clinical trial.
Passiflora incarnata
(500 mg),
Erythrina mulungu
(500 mg), or midazolam (15 mg) was orally administered 60 min before the surgery. The anxiety level of participants was evaluated using questionnaires and measurements of physical parameters, including heart rate (HR), blood pressure (BP), and oxygen saturation (SpO
2
).
Results
A total of 200 volunteers were included in this clinical trial. Considering each procedure independently, no significant differences (
p
> 0.05) in BP, HR, and SpO
2
were observed among the protocols.
Conclusions
Passiflora incarnata
showed a similar effect to midazolam but differed from placebo and mulungu, which were unable to control anxiety in this situation. Therefore, the results suggest that
Passiflora
configures an herbal medicine with an anxiolytic effect, adequate to use in third molar extractions.
Clinical relevance
The use of
Passiflora incarnata
may be an alternative to benzodiazepines for controlling anxiety in patients scheduled for oral surgery under local anesthesia.
Trial registration
ClinicalTrials.gov
: ANSI-388.427</description><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-020-03468-1</identifier><identifier>PMID: 32951121</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Anesthesia ; Anti-Anxiety Agents ; Anxiety ; Anxiolytics ; Benzodiazepines ; Blood pressure ; Clinical trials ; Dentistry ; Double-Blind Method ; Erythrina ; Heart rate ; Herbal medicine ; Humans ; Mandible ; Medicine ; Midazolam ; Molar, Third - surgery ; Molars ; Oral administration ; Original Article ; Passiflora ; Passiflora incarnata ; Patients ; Placebos ; Plant Extracts ; Surgery ; Tooth Extraction</subject><ispartof>Clinical oral investigations, 2021-03, Vol.25 (3), p.1579-1586</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-9aec62c3a483cb6dc18ebcb2fbcfc27227f65273616173bded527442a030279d3</citedby><cites>FETCH-LOGICAL-c375t-9aec62c3a483cb6dc18ebcb2fbcfc27227f65273616173bded527442a030279d3</cites><orcidid>0000-0001-7685-5150</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-020-03468-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-020-03468-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32951121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>da Cunha, Rafael Soares</creatorcontrib><creatorcontrib>Amorim, Klinger Souza</creatorcontrib><creatorcontrib>Gercina, Anne Caroline</creatorcontrib><creatorcontrib>de Oliveira, Allan Carlos Araújo</creatorcontrib><creatorcontrib>dos Santos Menezes, Liciane</creatorcontrib><creatorcontrib>Groppo, Francisco Carlos</creatorcontrib><creatorcontrib>Souza, Liane Maciel Almeida</creatorcontrib><title>Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Objectives
This study aimed to compare the effects of
Passiflora incarnata
,
Erythrina mulungu
, and midazolam in controlling anxiety in patients undergoing mandibular third molar extraction.
Methods
The volunteers underwent extraction of their third mandibular molars in a randomized, placebo-controlled, triple-blind, and parallel clinical trial.
Passiflora incarnata
(500 mg),
Erythrina mulungu
(500 mg), or midazolam (15 mg) was orally administered 60 min before the surgery. The anxiety level of participants was evaluated using questionnaires and measurements of physical parameters, including heart rate (HR), blood pressure (BP), and oxygen saturation (SpO
2
).
Results
A total of 200 volunteers were included in this clinical trial. Considering each procedure independently, no significant differences (
p
> 0.05) in BP, HR, and SpO
2
were observed among the protocols.
Conclusions
Passiflora incarnata
showed a similar effect to midazolam but differed from placebo and mulungu, which were unable to control anxiety in this situation. Therefore, the results suggest that
Passiflora
configures an herbal medicine with an anxiolytic effect, adequate to use in third molar extractions.
Clinical relevance
The use of
Passiflora incarnata
may be an alternative to benzodiazepines for controlling anxiety in patients scheduled for oral surgery under local anesthesia.
Trial registration
ClinicalTrials.gov
: ANSI-388.427</description><subject>Anesthesia</subject><subject>Anti-Anxiety Agents</subject><subject>Anxiety</subject><subject>Anxiolytics</subject><subject>Benzodiazepines</subject><subject>Blood pressure</subject><subject>Clinical trials</subject><subject>Dentistry</subject><subject>Double-Blind Method</subject><subject>Erythrina</subject><subject>Heart rate</subject><subject>Herbal medicine</subject><subject>Humans</subject><subject>Mandible</subject><subject>Medicine</subject><subject>Midazolam</subject><subject>Molar, Third - surgery</subject><subject>Molars</subject><subject>Oral administration</subject><subject>Original Article</subject><subject>Passiflora</subject><subject>Passiflora incarnata</subject><subject>Patients</subject><subject>Placebos</subject><subject>Plant Extracts</subject><subject>Surgery</subject><subject>Tooth Extraction</subject><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1LBCEYxiWKPrb-gQ4hdOkym1-rs8eIaoOgS53FcZzNxdFNHdj663M_KugQiL7i73leeR8AzjEaY4TEdSpbzSpEUIUo43WF98AxZpRXVAi8v6lJxac1PgInKS0QwowLegiOKJlOMCb4GCxnJjbKwd60VltvElRl-ZUN7iNbneAy2hBhDjC_2djCPjgVYRri3OoiM6sclc42-DG8gVH5NvT207RQB59jcG5dOus3cI5WuVNw0CmXzNnuHIHX-7uX21n19PzweHvzVGkqJrmaKqM50VSxmuqGtxrXptEN6RrdaSIIER2fEEE55ljQpjVtuTFGFKKIiGlLR-Bq67uM4X0wKcveJm2cU96EIUnCGOOIcD4p6OUfdBGG6MvvClXXuBaM8EKRLaVjSCmaTpbR9Cp-SIzkOg-5zUOWPOQmD4mL6GJnPTRlxD-S7wAKQLdAKk9-buJv739svwBwL5a7</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>da Cunha, Rafael Soares</creator><creator>Amorim, Klinger Souza</creator><creator>Gercina, Anne Caroline</creator><creator>de Oliveira, Allan Carlos Araújo</creator><creator>dos Santos Menezes, Liciane</creator><creator>Groppo, Francisco Carlos</creator><creator>Souza, Liane Maciel Almeida</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7685-5150</orcidid></search><sort><creationdate>20210301</creationdate><title>Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial</title><author>da Cunha, Rafael Soares ; Amorim, Klinger Souza ; Gercina, Anne Caroline ; de Oliveira, Allan Carlos Araújo ; dos Santos Menezes, Liciane ; Groppo, Francisco Carlos ; Souza, Liane Maciel Almeida</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-9aec62c3a483cb6dc18ebcb2fbcfc27227f65273616173bded527442a030279d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anesthesia</topic><topic>Anti-Anxiety Agents</topic><topic>Anxiety</topic><topic>Anxiolytics</topic><topic>Benzodiazepines</topic><topic>Blood pressure</topic><topic>Clinical trials</topic><topic>Dentistry</topic><topic>Double-Blind Method</topic><topic>Erythrina</topic><topic>Heart rate</topic><topic>Herbal medicine</topic><topic>Humans</topic><topic>Mandible</topic><topic>Medicine</topic><topic>Midazolam</topic><topic>Molar, Third - surgery</topic><topic>Molars</topic><topic>Oral administration</topic><topic>Original Article</topic><topic>Passiflora</topic><topic>Passiflora incarnata</topic><topic>Patients</topic><topic>Placebos</topic><topic>Plant Extracts</topic><topic>Surgery</topic><topic>Tooth Extraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>da Cunha, Rafael Soares</creatorcontrib><creatorcontrib>Amorim, Klinger Souza</creatorcontrib><creatorcontrib>Gercina, Anne Caroline</creatorcontrib><creatorcontrib>de Oliveira, Allan Carlos Araújo</creatorcontrib><creatorcontrib>dos Santos Menezes, Liciane</creatorcontrib><creatorcontrib>Groppo, Francisco Carlos</creatorcontrib><creatorcontrib>Souza, Liane Maciel Almeida</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>da Cunha, Rafael Soares</au><au>Amorim, Klinger Souza</au><au>Gercina, Anne Caroline</au><au>de Oliveira, Allan Carlos Araújo</au><au>dos Santos Menezes, Liciane</au><au>Groppo, Francisco Carlos</au><au>Souza, Liane Maciel Almeida</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>25</volume><issue>3</issue><spage>1579</spage><epage>1586</epage><pages>1579-1586</pages><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Objectives
This study aimed to compare the effects of
Passiflora incarnata
,
Erythrina mulungu
, and midazolam in controlling anxiety in patients undergoing mandibular third molar extraction.
Methods
The volunteers underwent extraction of their third mandibular molars in a randomized, placebo-controlled, triple-blind, and parallel clinical trial.
Passiflora incarnata
(500 mg),
Erythrina mulungu
(500 mg), or midazolam (15 mg) was orally administered 60 min before the surgery. The anxiety level of participants was evaluated using questionnaires and measurements of physical parameters, including heart rate (HR), blood pressure (BP), and oxygen saturation (SpO
2
).
Results
A total of 200 volunteers were included in this clinical trial. Considering each procedure independently, no significant differences (
p
> 0.05) in BP, HR, and SpO
2
were observed among the protocols.
Conclusions
Passiflora incarnata
showed a similar effect to midazolam but differed from placebo and mulungu, which were unable to control anxiety in this situation. Therefore, the results suggest that
Passiflora
configures an herbal medicine with an anxiolytic effect, adequate to use in third molar extractions.
Clinical relevance
The use of
Passiflora incarnata
may be an alternative to benzodiazepines for controlling anxiety in patients scheduled for oral surgery under local anesthesia.
Trial registration
ClinicalTrials.gov
: ANSI-388.427</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32951121</pmid><doi>10.1007/s00784-020-03468-1</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7685-5150</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1432-6981 |
| ispartof | Clinical oral investigations, 2021-03, Vol.25 (3), p.1579-1586 |
| issn | 1432-6981 1436-3771 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Anesthesia Anti-Anxiety Agents Anxiety Anxiolytics Benzodiazepines Blood pressure Clinical trials Dentistry Double-Blind Method Erythrina Heart rate Herbal medicine Humans Mandible Medicine Midazolam Molar, Third - surgery Molars Oral administration Original Article Passiflora Passiflora incarnata Patients Placebos Plant Extracts Surgery Tooth Extraction |
| title | Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial |
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