Effects of branched‐chain amino acids on postoperative tumor recurrence in patients undergoing curative resection for hepatocellular carcinoma: A randomized clinical trial
Background/Purpose No effective postoperative adjuvant therapies have been established for patients with hepatocellular carcinoma (HCC). The aim of this study was to investigate the effect of oral administration of branched‐chain amino acids (BCAA) on the recurrence‐free survival (RFS) after hepatic...
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| Veröffentlicht in: | Journal of hepato-biliary-pancreatic sciences 2020-11, Vol.27 (11), p.819-829 |
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| container_title | Journal of hepato-biliary-pancreatic sciences |
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| creator | Hachiya, Hiroyuki Aoki, Taku Iso, Yukihiro Shimizu, Takayuki Tago, Kazuma Park, Kyung Hwa Sakuraoka, Yuhki Shiraki, Takayuki Mori, Shozo Kubota, Keiichi |
| description | Background/Purpose
No effective postoperative adjuvant therapies have been established for patients with hepatocellular carcinoma (HCC). The aim of this study was to investigate the effect of oral administration of branched‐chain amino acids (BCAA) on the recurrence‐free survival (RFS) after hepatic resection in HCC patients.
Methods
In this randomized clinical trial, HCC patients undergoing curative resections were randomly assigned in a 1:1 ratio to the BCAA group or surgery‐alone group. The BCAA group received BCAA (Livact®) for up to 4 years. The primary endpoint was RFS. The secondary endpoint was overall survival (OS). Multivariate analysis was performed to detect the clinical characteristics significantly associated with RFS.
Results
Between January 2010 and October 2014, 156 patients (75 in BCAA group and 81 in surgery‐alone group) were enrolled in the study. Of these, two patients were excluded from the efficacy analysis. Comparison of the survival curves by the log rank test demonstrated no significant difference in the RFS (P = .579) or OS (P = .268) between the BCAA and the control group. Multivariate analysis revealed that the RFS was significantly associated with age and number of tumors. A beneficial effect of BCAA on the RFS was found in patients younger than 72 years old with a HbA1c level of |
| doi_str_mv | 10.1002/jhbp.830 |
| format | Article |
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No effective postoperative adjuvant therapies have been established for patients with hepatocellular carcinoma (HCC). The aim of this study was to investigate the effect of oral administration of branched‐chain amino acids (BCAA) on the recurrence‐free survival (RFS) after hepatic resection in HCC patients.
Methods
In this randomized clinical trial, HCC patients undergoing curative resections were randomly assigned in a 1:1 ratio to the BCAA group or surgery‐alone group. The BCAA group received BCAA (Livact®) for up to 4 years. The primary endpoint was RFS. The secondary endpoint was overall survival (OS). Multivariate analysis was performed to detect the clinical characteristics significantly associated with RFS.
Results
Between January 2010 and October 2014, 156 patients (75 in BCAA group and 81 in surgery‐alone group) were enrolled in the study. Of these, two patients were excluded from the efficacy analysis. Comparison of the survival curves by the log rank test demonstrated no significant difference in the RFS (P = .579) or OS (P = .268) between the BCAA and the control group. Multivariate analysis revealed that the RFS was significantly associated with age and number of tumors. A beneficial effect of BCAA on the RFS was found in patients younger than 72 years old with a HbA1c level of < 6.4%.
Conclusions
Oral BCAA supplementation could not reduce the risk of recurrence after hepatic resection in HCC patients; however, the results suggested that BCAA supplementation may be beneficial for selected patients who were younger and had mildly impaired glucose tolerance.
Highlight
Hachiya and colleagues conducted a single‐center, open‐label randomized clinical trial to investigate the effect of oral administration of branched‐chain amino acids on recurrence‐free survival after hepatic resection for hepatocellular carcinoma. Although the results suggested benefit in selected low‐risk patients, branched‐chain amino acids failed to reduce post‐operative recurrence of hepatocellular carcinoma.</description><identifier>ISSN: 1868-6974</identifier><identifier>EISSN: 1868-6982</identifier><identifier>DOI: 10.1002/jhbp.830</identifier><language>eng</language><publisher>Tokyo: Wiley Subscription Services, Inc</publisher><subject>Amino acids ; branched‐chain amino acids ; Clinical trials ; hepatectomy ; hepatocellular carcinoma ; Liver cancer ; Multivariate analysis ; overall survival ; recurrence‐free survival</subject><ispartof>Journal of hepato-biliary-pancreatic sciences, 2020-11, Vol.27 (11), p.819-829</ispartof><rights>2020 Japanese Society of Hepato‐Biliary‐Pancreatic Surgery</rights><rights>Copyright © 2020 Japanese Society of Hepato‐Biliary‐Pancreatic Surgery</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3500-6eb654313185b475c70b916c8c8f9da041de74570e80b8c16d6ced5af54e7f553</citedby><cites>FETCH-LOGICAL-c3500-6eb654313185b475c70b916c8c8f9da041de74570e80b8c16d6ced5af54e7f553</cites><orcidid>0000-0002-2868-5246</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjhbp.830$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjhbp.830$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Hachiya, Hiroyuki</creatorcontrib><creatorcontrib>Aoki, Taku</creatorcontrib><creatorcontrib>Iso, Yukihiro</creatorcontrib><creatorcontrib>Shimizu, Takayuki</creatorcontrib><creatorcontrib>Tago, Kazuma</creatorcontrib><creatorcontrib>Park, Kyung Hwa</creatorcontrib><creatorcontrib>Sakuraoka, Yuhki</creatorcontrib><creatorcontrib>Shiraki, Takayuki</creatorcontrib><creatorcontrib>Mori, Shozo</creatorcontrib><creatorcontrib>Kubota, Keiichi</creatorcontrib><title>Effects of branched‐chain amino acids on postoperative tumor recurrence in patients undergoing curative resection for hepatocellular carcinoma: A randomized clinical trial</title><title>Journal of hepato-biliary-pancreatic sciences</title><description>Background/Purpose
No effective postoperative adjuvant therapies have been established for patients with hepatocellular carcinoma (HCC). The aim of this study was to investigate the effect of oral administration of branched‐chain amino acids (BCAA) on the recurrence‐free survival (RFS) after hepatic resection in HCC patients.
Methods
In this randomized clinical trial, HCC patients undergoing curative resections were randomly assigned in a 1:1 ratio to the BCAA group or surgery‐alone group. The BCAA group received BCAA (Livact®) for up to 4 years. The primary endpoint was RFS. The secondary endpoint was overall survival (OS). Multivariate analysis was performed to detect the clinical characteristics significantly associated with RFS.
Results
Between January 2010 and October 2014, 156 patients (75 in BCAA group and 81 in surgery‐alone group) were enrolled in the study. Of these, two patients were excluded from the efficacy analysis. Comparison of the survival curves by the log rank test demonstrated no significant difference in the RFS (P = .579) or OS (P = .268) between the BCAA and the control group. Multivariate analysis revealed that the RFS was significantly associated with age and number of tumors. A beneficial effect of BCAA on the RFS was found in patients younger than 72 years old with a HbA1c level of < 6.4%.
Conclusions
Oral BCAA supplementation could not reduce the risk of recurrence after hepatic resection in HCC patients; however, the results suggested that BCAA supplementation may be beneficial for selected patients who were younger and had mildly impaired glucose tolerance.
Highlight
Hachiya and colleagues conducted a single‐center, open‐label randomized clinical trial to investigate the effect of oral administration of branched‐chain amino acids on recurrence‐free survival after hepatic resection for hepatocellular carcinoma. Although the results suggested benefit in selected low‐risk patients, branched‐chain amino acids failed to reduce post‐operative recurrence of hepatocellular carcinoma.</description><subject>Amino acids</subject><subject>branched‐chain amino acids</subject><subject>Clinical trials</subject><subject>hepatectomy</subject><subject>hepatocellular carcinoma</subject><subject>Liver cancer</subject><subject>Multivariate analysis</subject><subject>overall survival</subject><subject>recurrence‐free survival</subject><issn>1868-6974</issn><issn>1868-6982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kcFqFTEUhgexYKkFHyHgxs3U5E6SybirpVqlYBe6HjInJ725zCRjMmOpKx_BF_GlfBLP5YpCodkk8H__f_5wquqF4GeC883r3XaYz0zDn1THwmhT685snv57t_JZdVrKjtNpRNM1_Lj6dek9wlJY8mzINsIW3e8fP2FrQ2R2CjExC8GRHtmcypJmzHYJ35At65QyywhrzhgBGRlmkjBS2hod5tsU4i0j_WDIWGhSoCBPxi0SnADHcR1tZmAz0LDJvmHnjHq4NIXv6BiMIQawI1tysOPz6sjbseDp3_uk-vLu8vPFVX396f2Hi_PrGhrFea1x0ErSF4VRg2wVtHzohAYDxnfOcikctlK1HA0fDAjtNKBT1iuJrVeqOaleHXLnnL6uWJZ-CmXf1UZMa-k3UsrGaN1KQl8-QHdpzZHaEaWlkqYzzf9AyKmUjL6fc5hsvu8F7_er6_er62l1hNYH9C6MeP8o13-8enuz5_8A9R6fdQ</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Hachiya, Hiroyuki</creator><creator>Aoki, Taku</creator><creator>Iso, Yukihiro</creator><creator>Shimizu, Takayuki</creator><creator>Tago, Kazuma</creator><creator>Park, Kyung Hwa</creator><creator>Sakuraoka, Yuhki</creator><creator>Shiraki, Takayuki</creator><creator>Mori, Shozo</creator><creator>Kubota, Keiichi</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2868-5246</orcidid></search><sort><creationdate>202011</creationdate><title>Effects of branched‐chain amino acids on postoperative tumor recurrence in patients undergoing curative resection for hepatocellular carcinoma: A randomized clinical trial</title><author>Hachiya, Hiroyuki ; Aoki, Taku ; Iso, Yukihiro ; Shimizu, Takayuki ; Tago, Kazuma ; Park, Kyung Hwa ; Sakuraoka, Yuhki ; Shiraki, Takayuki ; Mori, Shozo ; Kubota, Keiichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3500-6eb654313185b475c70b916c8c8f9da041de74570e80b8c16d6ced5af54e7f553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Amino acids</topic><topic>branched‐chain amino acids</topic><topic>Clinical trials</topic><topic>hepatectomy</topic><topic>hepatocellular carcinoma</topic><topic>Liver cancer</topic><topic>Multivariate analysis</topic><topic>overall survival</topic><topic>recurrence‐free survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hachiya, Hiroyuki</creatorcontrib><creatorcontrib>Aoki, Taku</creatorcontrib><creatorcontrib>Iso, Yukihiro</creatorcontrib><creatorcontrib>Shimizu, Takayuki</creatorcontrib><creatorcontrib>Tago, Kazuma</creatorcontrib><creatorcontrib>Park, Kyung Hwa</creatorcontrib><creatorcontrib>Sakuraoka, Yuhki</creatorcontrib><creatorcontrib>Shiraki, Takayuki</creatorcontrib><creatorcontrib>Mori, Shozo</creatorcontrib><creatorcontrib>Kubota, Keiichi</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepato-biliary-pancreatic sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hachiya, Hiroyuki</au><au>Aoki, Taku</au><au>Iso, Yukihiro</au><au>Shimizu, Takayuki</au><au>Tago, Kazuma</au><au>Park, Kyung Hwa</au><au>Sakuraoka, Yuhki</au><au>Shiraki, Takayuki</au><au>Mori, Shozo</au><au>Kubota, Keiichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of branched‐chain amino acids on postoperative tumor recurrence in patients undergoing curative resection for hepatocellular carcinoma: A randomized clinical trial</atitle><jtitle>Journal of hepato-biliary-pancreatic sciences</jtitle><date>2020-11</date><risdate>2020</risdate><volume>27</volume><issue>11</issue><spage>819</spage><epage>829</epage><pages>819-829</pages><issn>1868-6974</issn><eissn>1868-6982</eissn><abstract>Background/Purpose
No effective postoperative adjuvant therapies have been established for patients with hepatocellular carcinoma (HCC). The aim of this study was to investigate the effect of oral administration of branched‐chain amino acids (BCAA) on the recurrence‐free survival (RFS) after hepatic resection in HCC patients.
Methods
In this randomized clinical trial, HCC patients undergoing curative resections were randomly assigned in a 1:1 ratio to the BCAA group or surgery‐alone group. The BCAA group received BCAA (Livact®) for up to 4 years. The primary endpoint was RFS. The secondary endpoint was overall survival (OS). Multivariate analysis was performed to detect the clinical characteristics significantly associated with RFS.
Results
Between January 2010 and October 2014, 156 patients (75 in BCAA group and 81 in surgery‐alone group) were enrolled in the study. Of these, two patients were excluded from the efficacy analysis. Comparison of the survival curves by the log rank test demonstrated no significant difference in the RFS (P = .579) or OS (P = .268) between the BCAA and the control group. Multivariate analysis revealed that the RFS was significantly associated with age and number of tumors. A beneficial effect of BCAA on the RFS was found in patients younger than 72 years old with a HbA1c level of < 6.4%.
Conclusions
Oral BCAA supplementation could not reduce the risk of recurrence after hepatic resection in HCC patients; however, the results suggested that BCAA supplementation may be beneficial for selected patients who were younger and had mildly impaired glucose tolerance.
Highlight
Hachiya and colleagues conducted a single‐center, open‐label randomized clinical trial to investigate the effect of oral administration of branched‐chain amino acids on recurrence‐free survival after hepatic resection for hepatocellular carcinoma. Although the results suggested benefit in selected low‐risk patients, branched‐chain amino acids failed to reduce post‐operative recurrence of hepatocellular carcinoma.</abstract><cop>Tokyo</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/jhbp.830</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2868-5246</orcidid></addata></record> |
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| issn | 1868-6974 1868-6982 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Amino acids branched‐chain amino acids Clinical trials hepatectomy hepatocellular carcinoma Liver cancer Multivariate analysis overall survival recurrence‐free survival |
| title | Effects of branched‐chain amino acids on postoperative tumor recurrence in patients undergoing curative resection for hepatocellular carcinoma: A randomized clinical trial |
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