Photoredox-Catalyzed α‑C(sp3)–H Activation of Unprotected Secondary Amines: Facile Access to 1,4-Dicarbonyl Compounds

Photoredox-Catalyzed α‑C(sp3)–H Activation of Unprotected Secondary Amines: Facile Access to 1,4-Dicarbonyl Compounds

A photoredox-catalyzed α-C­(sp3)–H activation approach of unprotected secondary amines is reported. Such transformations provide facile access to various 1,4-dicarbonyl compounds using readily available amines and α,β-unsaturated compounds as feedstocks under air conditions. The substrate scope of t...

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Veröffentlicht in:Organic letters 2020-10, Vol.22 (19), p.7460-7464
Hauptverfasser: Zhang, Qian, Huang, Yan, Zhan, Le-Wu, Tang, Wan-Ying, Hou, Jing, Li, Bin-Dong
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container_end_page 7464
container_issue 19
container_start_page 7460
container_title Organic letters
container_volume 22
creator Zhang, Qian
Huang, Yan
Zhan, Le-Wu
Tang, Wan-Ying
Hou, Jing
Li, Bin-Dong
description A photoredox-catalyzed α-C­(sp3)–H activation approach of unprotected secondary amines is reported. Such transformations provide facile access to various 1,4-dicarbonyl compounds using readily available amines and α,β-unsaturated compounds as feedstocks under air conditions. The substrate scope of this method is broad, and a wide array of functional groups are tolerated.
doi_str_mv 10.1021/acs.orglett.0c02571
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title Photoredox-Catalyzed α‑C(sp3)–H Activation of Unprotected Secondary Amines: Facile Access to 1,4-Dicarbonyl Compounds
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