PINK1-mediated mitophagy protects against hepatic ischemia/reperfusion injury by restraining NLRP3 inflammasome activation

Activation of nucleotide-binding domain leucine-rich repeat containing family pyrin domain containing 3 (NLRP3) inflammasome in Kupffer cells (KCs) contributes significantly to hepatic ischemia/reperfusion (I/R) injury, while the mechanism of how NLRP3 inflammasome is regulated remains less well def...

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Veröffentlicht in:	Free radical biology & medicine 2020-11, Vol.160, p.871-886
Hauptverfasser:	Xu, Ying, Tang, Yinbing, Lu, Jiawei, Zhang, Weiya, Zhu, Yan, Zhang, Shouliang, Ma, Gui, Jiang, Pengcheng, Zhang, Wenbo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Hepatic ischemia/reperfusion injury Inflammasome Inflammasomes Mice Mice, Inbred C57BL Mitophagy NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLRP3 PINK1 Protein Kinases - genetics Reperfusion Injury - genetics
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