Distribution of segmental chromosomal alterations in neuroblastoma
Background Neuroblastoma (NB) is a heterogeneous tumor with extremely diverse prognosis according to clinical and genetic factors such as specific combinations of chromosomal imbalances. Methods Molecular karyotyping data from a national neuroblastic tumor database of 155 NB samples were analyzed an...
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| Veröffentlicht in: | Clinical & translational oncology 2021-06, Vol.23 (6), p.1096-1104 |
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| creator | Juan Ribelles, A. Gargallo, P. Ferriol, C. Segura, V. Yáñez, Y. Juan, B. Cañada, A. J. Font de Mora, J. Cañete, A. Castel, V. |
| description | Background
Neuroblastoma (NB) is a heterogeneous tumor with extremely diverse prognosis according to clinical and genetic factors such as specific combinations of chromosomal imbalances.
Methods
Molecular karyotyping data from a national neuroblastic tumor database of 155 NB samples were analyzed and related to clinical data.
Results
Segmental chromosomal alterations (SCA) were detected in 102 NB, whereas 45 only displayed numerical alterations. Incidence of SCA was higher in stage M (92%) and MYCN amplified (MNA) NB (96%). Presence of SCA was associated with older age, especially 1q gain and 3p deletion. 96% of the deaths were observed in the SCA group and 85% of the relapsed NB contained SCA. The alteration most commonly associated with a higher number of other segmental rearrangements was 11q deletion, followed by 4p deletion. Whole-chromosome 19 gain was associated with lower stages, absence of SCA and better outcome.
Conclusions
SCA are not randomly distributed and are concentrated on recurrent chromosomes. The most frequently affected chromosomes identify prognostic factors in specific risk groups. SCA are associated with older age and MNA. We have identified a small subset of patients with better outcome that share whole-chromosome 19 numeric gain, suggesting its use as a prognostic biomarker in NB. |
| doi_str_mv | 10.1007/s12094-020-02497-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2444378708</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2444378708</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-79c68c9d29ca874d02bbac79e50ae04f006302abfda630c9458cce4f76ea2aeb3</originalsourceid><addsrcrecordid>eNp9kL1OwzAURi0EoqXwAgwoI0vgxnFie4TyK1ViAYnNcpybkiqJi-0MvD0uKYwMlj_5nvtJPoScZ3CVAfBrn1GQLAUK8TDJU3pA5lkpZZpDURzuMzDxPiMn3m8gvpZZdkxmOZVMSMHm5Pau9cG11RhaOyS2STyuexyC7hLz4Wxvve1j1l1Ap3eMT9ohGXB0tuq0D3F6So4a3Xk8298L8vZw_7p8Slcvj8_Lm1VqcsZDyqUphZE1lUYLzmqgVaUNl1iARmANQJkD1VVT6xiMZIUwBlnDS9RUY5UvyOXUu3X2c0QfVN96g12nB7SjV5QxlnPBQUSUTqhx1nuHjdq6ttfuS2Wgdu7U5E5Fd-rHnaJx6WLfP1Y91n8rv7IikE-Aj6NhjU5t7OiG-Of_ar8BZ857lA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2444378708</pqid></control><display><type>article</type><title>Distribution of segmental chromosomal alterations in neuroblastoma</title><source>SpringerLink Journals</source><creator>Juan Ribelles, A. ; Gargallo, P. ; Ferriol, C. ; Segura, V. ; Yáñez, Y. ; Juan, B. ; Cañada, A. J. ; Font de Mora, J. ; Cañete, A. ; Castel, V.</creator><creatorcontrib>Juan Ribelles, A. ; Gargallo, P. ; Ferriol, C. ; Segura, V. ; Yáñez, Y. ; Juan, B. ; Cañada, A. J. ; Font de Mora, J. ; Cañete, A. ; Castel, V.</creatorcontrib><description>Background
Neuroblastoma (NB) is a heterogeneous tumor with extremely diverse prognosis according to clinical and genetic factors such as specific combinations of chromosomal imbalances.
Methods
Molecular karyotyping data from a national neuroblastic tumor database of 155 NB samples were analyzed and related to clinical data.
Results
Segmental chromosomal alterations (SCA) were detected in 102 NB, whereas 45 only displayed numerical alterations. Incidence of SCA was higher in stage M (92%) and MYCN amplified (MNA) NB (96%). Presence of SCA was associated with older age, especially 1q gain and 3p deletion. 96% of the deaths were observed in the SCA group and 85% of the relapsed NB contained SCA. The alteration most commonly associated with a higher number of other segmental rearrangements was 11q deletion, followed by 4p deletion. Whole-chromosome 19 gain was associated with lower stages, absence of SCA and better outcome.
Conclusions
SCA are not randomly distributed and are concentrated on recurrent chromosomes. The most frequently affected chromosomes identify prognostic factors in specific risk groups. SCA are associated with older age and MNA. We have identified a small subset of patients with better outcome that share whole-chromosome 19 numeric gain, suggesting its use as a prognostic biomarker in NB.</description><identifier>ISSN: 1699-048X</identifier><identifier>EISSN: 1699-3055</identifier><identifier>DOI: 10.1007/s12094-020-02497-2</identifier><identifier>PMID: 32948984</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Medicine ; Medicine & Public Health ; Oncology ; Research Article</subject><ispartof>Clinical & translational oncology, 2021-06, Vol.23 (6), p.1096-1104</ispartof><rights>Federación de Sociedades Españolas de Oncología (FESEO) 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-79c68c9d29ca874d02bbac79e50ae04f006302abfda630c9458cce4f76ea2aeb3</citedby><cites>FETCH-LOGICAL-c347t-79c68c9d29ca874d02bbac79e50ae04f006302abfda630c9458cce4f76ea2aeb3</cites><orcidid>0000-0002-2662-7632</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12094-020-02497-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12094-020-02497-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27906,27907,41470,42539,51301</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32948984$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Juan Ribelles, A.</creatorcontrib><creatorcontrib>Gargallo, P.</creatorcontrib><creatorcontrib>Ferriol, C.</creatorcontrib><creatorcontrib>Segura, V.</creatorcontrib><creatorcontrib>Yáñez, Y.</creatorcontrib><creatorcontrib>Juan, B.</creatorcontrib><creatorcontrib>Cañada, A. J.</creatorcontrib><creatorcontrib>Font de Mora, J.</creatorcontrib><creatorcontrib>Cañete, A.</creatorcontrib><creatorcontrib>Castel, V.</creatorcontrib><title>Distribution of segmental chromosomal alterations in neuroblastoma</title><title>Clinical & translational oncology</title><addtitle>Clin Transl Oncol</addtitle><addtitle>Clin Transl Oncol</addtitle><description>Background
Neuroblastoma (NB) is a heterogeneous tumor with extremely diverse prognosis according to clinical and genetic factors such as specific combinations of chromosomal imbalances.
Methods
Molecular karyotyping data from a national neuroblastic tumor database of 155 NB samples were analyzed and related to clinical data.
Results
Segmental chromosomal alterations (SCA) were detected in 102 NB, whereas 45 only displayed numerical alterations. Incidence of SCA was higher in stage M (92%) and MYCN amplified (MNA) NB (96%). Presence of SCA was associated with older age, especially 1q gain and 3p deletion. 96% of the deaths were observed in the SCA group and 85% of the relapsed NB contained SCA. The alteration most commonly associated with a higher number of other segmental rearrangements was 11q deletion, followed by 4p deletion. Whole-chromosome 19 gain was associated with lower stages, absence of SCA and better outcome.
Conclusions
SCA are not randomly distributed and are concentrated on recurrent chromosomes. The most frequently affected chromosomes identify prognostic factors in specific risk groups. SCA are associated with older age and MNA. We have identified a small subset of patients with better outcome that share whole-chromosome 19 numeric gain, suggesting its use as a prognostic biomarker in NB.</description><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Research Article</subject><issn>1699-048X</issn><issn>1699-3055</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kL1OwzAURi0EoqXwAgwoI0vgxnFie4TyK1ViAYnNcpybkiqJi-0MvD0uKYwMlj_5nvtJPoScZ3CVAfBrn1GQLAUK8TDJU3pA5lkpZZpDURzuMzDxPiMn3m8gvpZZdkxmOZVMSMHm5Pau9cG11RhaOyS2STyuexyC7hLz4Wxvve1j1l1Ap3eMT9ohGXB0tuq0D3F6So4a3Xk8298L8vZw_7p8Slcvj8_Lm1VqcsZDyqUphZE1lUYLzmqgVaUNl1iARmANQJkD1VVT6xiMZIUwBlnDS9RUY5UvyOXUu3X2c0QfVN96g12nB7SjV5QxlnPBQUSUTqhx1nuHjdq6ttfuS2Wgdu7U5E5Fd-rHnaJx6WLfP1Y91n8rv7IikE-Aj6NhjU5t7OiG-Of_ar8BZ857lA</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Juan Ribelles, A.</creator><creator>Gargallo, P.</creator><creator>Ferriol, C.</creator><creator>Segura, V.</creator><creator>Yáñez, Y.</creator><creator>Juan, B.</creator><creator>Cañada, A. J.</creator><creator>Font de Mora, J.</creator><creator>Cañete, A.</creator><creator>Castel, V.</creator><general>Springer International Publishing</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2662-7632</orcidid></search><sort><creationdate>20210601</creationdate><title>Distribution of segmental chromosomal alterations in neuroblastoma</title><author>Juan Ribelles, A. ; Gargallo, P. ; Ferriol, C. ; Segura, V. ; Yáñez, Y. ; Juan, B. ; Cañada, A. J. ; Font de Mora, J. ; Cañete, A. ; Castel, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-79c68c9d29ca874d02bbac79e50ae04f006302abfda630c9458cce4f76ea2aeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Research Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Juan Ribelles, A.</creatorcontrib><creatorcontrib>Gargallo, P.</creatorcontrib><creatorcontrib>Ferriol, C.</creatorcontrib><creatorcontrib>Segura, V.</creatorcontrib><creatorcontrib>Yáñez, Y.</creatorcontrib><creatorcontrib>Juan, B.</creatorcontrib><creatorcontrib>Cañada, A. J.</creatorcontrib><creatorcontrib>Font de Mora, J.</creatorcontrib><creatorcontrib>Cañete, A.</creatorcontrib><creatorcontrib>Castel, V.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical & translational oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Juan Ribelles, A.</au><au>Gargallo, P.</au><au>Ferriol, C.</au><au>Segura, V.</au><au>Yáñez, Y.</au><au>Juan, B.</au><au>Cañada, A. J.</au><au>Font de Mora, J.</au><au>Cañete, A.</au><au>Castel, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of segmental chromosomal alterations in neuroblastoma</atitle><jtitle>Clinical & translational oncology</jtitle><stitle>Clin Transl Oncol</stitle><addtitle>Clin Transl Oncol</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>23</volume><issue>6</issue><spage>1096</spage><epage>1104</epage><pages>1096-1104</pages><issn>1699-048X</issn><eissn>1699-3055</eissn><abstract>Background
Neuroblastoma (NB) is a heterogeneous tumor with extremely diverse prognosis according to clinical and genetic factors such as specific combinations of chromosomal imbalances.
Methods
Molecular karyotyping data from a national neuroblastic tumor database of 155 NB samples were analyzed and related to clinical data.
Results
Segmental chromosomal alterations (SCA) were detected in 102 NB, whereas 45 only displayed numerical alterations. Incidence of SCA was higher in stage M (92%) and MYCN amplified (MNA) NB (96%). Presence of SCA was associated with older age, especially 1q gain and 3p deletion. 96% of the deaths were observed in the SCA group and 85% of the relapsed NB contained SCA. The alteration most commonly associated with a higher number of other segmental rearrangements was 11q deletion, followed by 4p deletion. Whole-chromosome 19 gain was associated with lower stages, absence of SCA and better outcome.
Conclusions
SCA are not randomly distributed and are concentrated on recurrent chromosomes. The most frequently affected chromosomes identify prognostic factors in specific risk groups. SCA are associated with older age and MNA. We have identified a small subset of patients with better outcome that share whole-chromosome 19 numeric gain, suggesting its use as a prognostic biomarker in NB.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32948984</pmid><doi>10.1007/s12094-020-02497-2</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2662-7632</orcidid></addata></record> |
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| subjects | Medicine Medicine & Public Health Oncology Research Article |
| title | Distribution of segmental chromosomal alterations in neuroblastoma |
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