Advanced polymeric nanotechnology to augment therapeutic delivery and disease diagnosis

Therapeutic and diagnostic payloads are usually associated with properties that compromise their efficacy, such as poor aqueous solubility, short half-life, low bioavailability, nonspecific accumulation and diverse side effects. Nanotechnological solutions have emerged to circumvent some of these dr...

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Veröffentlicht in:Nanomedicine (London, England) England), 2020-08, Vol.15 (23), p.2287-2309
Hauptverfasser: Martins, Cláudia, Chauhan, Veeren M, Araújo, Marco, Abouselo, Amjad, Barrias, Cristina C, Aylott, Jonathan W, Sarmento, Bruno
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container_end_page 2309
container_issue 23
container_start_page 2287
container_title Nanomedicine (London, England)
container_volume 15
creator Martins, Cláudia
Chauhan, Veeren M
Araújo, Marco
Abouselo, Amjad
Barrias, Cristina C
Aylott, Jonathan W
Sarmento, Bruno
description Therapeutic and diagnostic payloads are usually associated with properties that compromise their efficacy, such as poor aqueous solubility, short half-life, low bioavailability, nonspecific accumulation and diverse side effects. Nanotechnological solutions have emerged to circumvent some of these drawbacks, augmenting therapeutic and/or diagnostic outcomes. Nanotechnology has benefited from the rise in polymer science research for the development of novel nanosystems for therapeutic and diagnostic purposes. Polymers are a widely used class of biomaterials, with a considerable number of regulatory approvals for application in clinics. In addition to their versatility in production and functionalization, several synthetic and natural polymers demonstrate biocompatible properties that dictate their successful biological performance. This article highlights the physicochemical characteristics of a variety of natural and synthetic biocompatible polymers, as well as their role in the manufacture of nanotechnology-based systems, state-of-art applications in disease treatment and diagnosis, and current challenges in finding a way to clinics.
doi_str_mv 10.2217/nnm-2020-0145
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subjects Amino acids
Biocompatibility
Biodegradation
Biomedical materials
Collagen
diagnosis
Enzymes
Hyaluronic acid
Hydrogels
Medical diagnosis
Nanomaterials
Nanotechnology
Polymers
Proteins
therapeutic delivery
title Advanced polymeric nanotechnology to augment therapeutic delivery and disease diagnosis
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