De novo polyamine synthesis supports metabolic and functional responses in activated murine NK cells

Cellular metabolism is dynamically regulated in NK cells and strongly influences their responses. Metabolic dysfunction is linked to defective NK cell responses in diseases such as obesity and cancer. The transcription factors, sterol regulatory element binding protein (SREBP) and cMyc, are crucial...

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Veröffentlicht in:	European journal of immunology 2021-01, Vol.51 (1), p.91-102
Hauptverfasser:	O'Brien, Katie L., Assmann, Nadine, O'Connor, Eimear, Keane, Cathal, Walls, Jessica, Choi, Chloe, Oefner, Peter J., Gardiner, Clair M., Dettmer, Katja, Finlay, David K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell activation Cells, Cultured Cholesterol cMyc Effector cells Eukaryotic Translation Initiation Factor 5A Female Glycolysis Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Kinases Lymphocytes Lysine - analogs & derivatives Lysine - metabolism Male Metabolism Mice Mice, Inbred C57BL Microenvironments natural killer cell Natural killer cells Oxidative metabolism Oxidative Phosphorylation Peptide Initiation Factors - metabolism Polyamines Polyamines - metabolism Polyamines - pharmacology Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism RNA-Binding Proteins - metabolism Spermidine SREBP Sterol Regulatory Element Binding Proteins - deficiency Sterol Regulatory Element Binding Proteins - metabolism Sterol regulatory element-binding protein Transcription factors Translation
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