Synthesis of Fluoro‐, Monofluoromethyl‐, Difluoromethyl‐, and Trifluoromethyl‐Substituted Three‐Membered Rings

This Minireview describes recent advances toward the synthesis of fluoro‐, monofluoromethyl‐, difluoromethyl‐, and trifluoromethyl‐substituted three‐membered rings such as cyclopropanes, aziridines, epoxides, episulfides, cyclopropenes, and 2 H‐azirines. The main synthetic methodologies since 2016 for cyclopropanes and since 2010 for the other three‐membered rings are reported. Better with three: Fluorinated three‐membered rings are valuable compounds with many applications. In this Minireview, the synthesis of fluoro‐, monofluoromethyl‐, difluoromethyl‐, and trifluoromethyl‐substituted cyclopropanes, cyclopropenes, aziridines, azirines, epoxides, and thiiranes over the past decade are described.