Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment

Identifying signals in the tumor microenvironment (TME) that shape CD8+ T cell phenotype can inform novel therapeutic approaches for cancer. Here, we identified a gradient of increasing glucocorticoid receptor (GR) expression and signaling from naïve to dysfunctional CD8+ tumor-infiltrating lymphocy...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2020-09, Vol.53 (3), p.658-671.e6
Hauptverfasser:	Acharya, Nandini, Madi, Asaf, Zhang, Huiyuan, Klapholz, Max, Escobar, Giulia, Dulberg, Shai, Christian, Elena, Ferreira, Michelle, Dixon, Karen O., Fell, Geoffrey, Tooley, Katherine, Mangani, Davide, Xia, Junrong, Singer, Meromit, Bosenberg, Marcus, Neuberg, Donna, Rozenblatt-Rosen, Orit, Regev, Aviv, Kuchroo, Vijay K., Anderson, Ana C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Active control Animals Biosynthesis Cancer Cancer immunotherapy CD8 antigen CD8+ T cell CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Cell activation Cell differentiation Cell Line, Tumor Cytokines Differentiation (biology) dysfunction exhaustion Gene expression Genotype & phenotype glucocorticoid Glucocorticoids Glucocorticoids - metabolism Growth inhibition Hematopoiesis - immunology Hepatocyte nuclear factor 1 Hepatocyte Nuclear Factor 1-alpha - biosynthesis Immune checkpoint immune checkpoint blockade Immune Checkpoint Inhibitors Immunotherapy Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Macrophages Macrophages - immunology Macrophages - metabolism Melanoma Melanoma, Experimental - pathology Mice Mice, Inbred C57BL Mice, Knockout Monocytes Nr3c1 Phenotypes Receptors Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Signal Transduction - immunology Signaling steroid Steroidogenesis Steroids TCF-1 Transcription activation Tumor Microenvironment - immunology tumor-associated macrophages Tumor-infiltrating lymphocytes Tumors
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