In vitro-in silico-based probabilistic risk assessment of combined exposure to bisphenol A and its analogues by integrating ToxCast high-throughput in vitro assays with in vitro to in vivo extrapolation (IVIVE) via physiologically based pharmacokinetic (PBPK) modeling

[Display omitted] •An in vitro- and in silico-based integrated risk assessment approach is described.•This approach is used to derive human equivalent doses for BPA, BPS, BPF, and BPAF.•Combined risks of BPA and its analogues for different populations are assessed.•Combined risks for toddlers and ad...

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Veröffentlicht in:	Journal of hazardous materials 2020-11, Vol.399, p.122856-122856, Article 122856
Hauptverfasser:	Lin, Yi-Jun, Lin, Zhoumeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Benzhydryl Compounds - toxicity Bisphenol AF Bisphenol F Bisphenol S Combined risk assessment Computer Simulation High-Throughput Screening Assays Humans In vitro to in vivo extrapolation (IVIVE) Phenols Risk Assessment
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