An Early Microglial Response Is Needed To Efficiently Control Herpes Simplex Virus Encephalitis

The role of a signaling pathway through macrophage colony-stimulating factor (MCSF) and its receptor, macrophage colony-stimulating factor 1 receptor (CSF1R), during experimental herpes simplex virus 1 (HSV-1) encephalitis (HSE) was studied by two different approaches. First, we evaluated the effect...

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Veröffentlicht in:	Journal of virology 2020-11, Vol.94 (23)
Hauptverfasser:	Uyar, Olus, Laflamme, Nataly, Piret, Jocelyne, Venable, Marie-Christine, Carbonneau, Julie, Zarrouk, Karima, Rivest, Serge, Boivin, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - virology Central Nervous System - metabolism Chemokines - metabolism Cytokines - metabolism Disease Models, Animal Encephalitis, Herpes Simplex - metabolism Herpesvirus 1, Human - metabolism Macrophage Colony-Stimulating Factor - genetics Macrophage Colony-Stimulating Factor - metabolism Macrophage Colony-Stimulating Factor - pharmacology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Microglia - metabolism Microglia - virology Monocytes - metabolism Pathogenesis and Immunity Phagocytosis Receptor, Macrophage Colony-Stimulating Factor - genetics Receptor, Macrophage Colony-Stimulating Factor - metabolism Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Viral Load
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