Effects of metformin on the prevention of bisphosphonate-related osteonecrosis of the jaw-like lesions in rats

PURPOSEIn this study, we aimed to investigate the effect of glucose metabolism on bone healing after tooth extraction in an osteoporosis rat model administered zoledronic acid (ZA) and dexamethasone (DX). METHODSIn total, 24 male Wistar rats (4 weeks old) were randomly assigned to four groups: Contr...

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Veröffentlicht in:Journal of prosthodontic research 2021-01, Vol.65 (2), p.219-224
Hauptverfasser: Nakagawa, Tomohito, Tsuka, Shintaro, Aonuma, Fumiko, Nodai, Tomotaka, Munemasa, Takashi, Tamura, Akiko, Mukaibo, Taro, Kondo, Yusuke, Masaki, Chihiro, Hosokawa, Ryuji
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Sprache:eng
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