Status of oxidative stress markers, advanced glycation index, and polyol pathway in age-related cataract subjects with and without diabetes
One of the major public health issues is the rising prevalence of cataracts, a primary reason for preventable blindness. The causes for the development of age-related cataracts and accelerated cataractogenesis in diabetes are multifactorial. Hence, this study was designed to examine the status and r...
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| Veröffentlicht in: | Experimental eye research 2020-11, Vol.200, p.108230-108230, Article 108230 |
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| creator | Chitra, P. Swathi Chaki, Debolina Boiroju, Naveen K. Mokalla, Thirupathi R. Gadde, Aruna K. Agraharam, Satish G. Reddy, G. Bhanuprakash |
| description | One of the major public health issues is the rising prevalence of cataracts, a primary reason for preventable blindness. The causes for the development of age-related cataracts and accelerated cataractogenesis in diabetes are multifactorial. Hence, this study was designed to examine the status and relationship between the three majorly associated molecular events, namely, oxidative stress, non-enzymatic glycation, and polyol pathway in age-related cataracts with and without diabetes. A total of 472 subjects were distributed into four groups: non-diabetic subjects with clear lens (135), diabetic subjects with clear lens (40), non-diabetic subjects with cataract (174), and diabetic subjects with cataract (123). Cataracts were graded by slit-lamp examination according to the Lens Opacities Classification System III. Age at onset of cataract, type of opacity, anthropometric measurements, and sociodemographic characteristics were recorded, and clinical profile was examined. Plasma oxidative stress markers were assessed by estimating the lipid peroxidation end product malondialdehyde, protein oxidation products protein carbonyls, and DNA oxidative damage marker 8-hydroxy-2-deoxyguanosine. Plasma advanced glycation end products index, erythrocyte aldose reductase activity, and sorbitol levels were evaluated. After adjusting for age, plasma malondialdehyde levels were significantly higher in diabetic cataracts (P |
| doi_str_mv | 10.1016/j.exer.2020.108230 |
| format | Article |
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•Nuclear cataract was more predominant in both diabetic and non-diabetic subjects.•Lipid peroxidation in age-related cataracts is independent of diabetes.•Only the presence of diabetes augmented plasma advanced glycation index.•Disease-free aging and controlled diabetes activated the polyol pathway equally.</description><identifier>ISSN: 0014-4835</identifier><identifier>EISSN: 1096-0007</identifier><identifier>DOI: 10.1016/j.exer.2020.108230</identifier><identifier>PMID: 32931824</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Advanced glycation index ; Age-related cataracts ; Aged ; Aged, 80 and over ; Aldose reductase ; And Sorbitol ; Biomarkers - metabolism ; Cataract - complications ; Cataract - metabolism ; Clear lens ; Diabetes ; Diabetes Mellitus - metabolism ; Female ; Follow-Up Studies ; Glycation End Products, Advanced - metabolism ; Glycosylation ; Humans ; Lens, Crystalline - metabolism ; Lipid Peroxidation ; Male ; Middle Aged ; Oxidative Stress ; Polymers - metabolism ; Retrospective Studies</subject><ispartof>Experimental eye research, 2020-11, Vol.200, p.108230-108230, Article 108230</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-1b2b9395417452e021db9170a26a7c8c42b06e976db80ff6129cb5f5b1aa0453</citedby><cites>FETCH-LOGICAL-c356t-1b2b9395417452e021db9170a26a7c8c42b06e976db80ff6129cb5f5b1aa0453</cites><orcidid>0000-0003-4787-3944 ; 0000-0002-6329-7206</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014483520304887$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32931824$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chitra, P. Swathi</creatorcontrib><creatorcontrib>Chaki, Debolina</creatorcontrib><creatorcontrib>Boiroju, Naveen K.</creatorcontrib><creatorcontrib>Mokalla, Thirupathi R.</creatorcontrib><creatorcontrib>Gadde, Aruna K.</creatorcontrib><creatorcontrib>Agraharam, Satish G.</creatorcontrib><creatorcontrib>Reddy, G. Bhanuprakash</creatorcontrib><title>Status of oxidative stress markers, advanced glycation index, and polyol pathway in age-related cataract subjects with and without diabetes</title><title>Experimental eye research</title><addtitle>Exp Eye Res</addtitle><description>One of the major public health issues is the rising prevalence of cataracts, a primary reason for preventable blindness. The causes for the development of age-related cataracts and accelerated cataractogenesis in diabetes are multifactorial. Hence, this study was designed to examine the status and relationship between the three majorly associated molecular events, namely, oxidative stress, non-enzymatic glycation, and polyol pathway in age-related cataracts with and without diabetes. A total of 472 subjects were distributed into four groups: non-diabetic subjects with clear lens (135), diabetic subjects with clear lens (40), non-diabetic subjects with cataract (174), and diabetic subjects with cataract (123). Cataracts were graded by slit-lamp examination according to the Lens Opacities Classification System III. Age at onset of cataract, type of opacity, anthropometric measurements, and sociodemographic characteristics were recorded, and clinical profile was examined. Plasma oxidative stress markers were assessed by estimating the lipid peroxidation end product malondialdehyde, protein oxidation products protein carbonyls, and DNA oxidative damage marker 8-hydroxy-2-deoxyguanosine. Plasma advanced glycation end products index, erythrocyte aldose reductase activity, and sorbitol levels were evaluated. After adjusting for age, plasma malondialdehyde levels were significantly higher in diabetic cataracts (P < 0.001) and non-diabetic cataract subjects (P < 0.05), compared to non-diabetic subjects with clear lens. Plasma advanced glycation end products index was significantly higher (P < 0.05) only in diabetic cataracts, but not in non-diabetic subjects with cataracts. Aldose reductase activity and sorbitol levels were significantly higher (P < 0.001) in both diabetic and non-diabetic subjects with cataract compared to non-diabetic subjects with clear lens. The data indicated that plasma lipid peroxidation in age-related cataracts was independent of diabetes. An association of pronounced glycation was observed only in diabetic cataracts but not in non-diabetic cataracts and polyol flux between diabetic cataracts and non-diabetic cataracts was comparable.
•Nuclear cataract was more predominant in both diabetic and non-diabetic subjects.•Lipid peroxidation in age-related cataracts is independent of diabetes.•Only the presence of diabetes augmented plasma advanced glycation index.•Disease-free aging and controlled diabetes activated the polyol pathway equally.</description><subject>Adult</subject><subject>Advanced glycation index</subject><subject>Age-related cataracts</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aldose reductase</subject><subject>And Sorbitol</subject><subject>Biomarkers - metabolism</subject><subject>Cataract - complications</subject><subject>Cataract - metabolism</subject><subject>Clear lens</subject><subject>Diabetes</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glycation End Products, Advanced - metabolism</subject><subject>Glycosylation</subject><subject>Humans</subject><subject>Lens, Crystalline - metabolism</subject><subject>Lipid Peroxidation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxidative Stress</subject><subject>Polymers - metabolism</subject><subject>Retrospective Studies</subject><issn>0014-4835</issn><issn>1096-0007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctuFDEQRS1ERIbAD7BAXrKgB7_6JbFBUXhIkbJI9lbZrk489LQH2z2Z-Yb8NG4msGRlq-rcK9W9hLzjbM0Zbz5t1njAuBZMLINOSPaCrDjrm4ox1r4kK8a4qlQn63PyOqVNmUrVqlfkXIpe8k6oFXm6zZDnRMNAw8E7yH6PNOWIKdEtxJ8Y00cKbg-TRUfvx6MtSJionxweymZydBfGYxjpDvLDIxzLhsI9VhFHyEVSeIhgM02z2aDNiT76_PBHuHzCnKnzYDBjekPOBhgTvn1-L8jd16u7y-_V9c23H5dfrisr6yZX3AjTy75WvFW1QCa4Mz1vGYgGWttZJQxrsG8bZzo2DA0XvTX1UBsOwFQtL8iHk-0uhl8zpqy3PlkcR5gwzEkLpWQtVN13BRUn1MaQUsRB76IvsRw1Z3rpQG_00oFeOtCnDoro_bP_bLbo_kn-hl6AzycAy5F7X-TJelwC9rEkpF3w__P_DVbumgE</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Chitra, P. Swathi</creator><creator>Chaki, Debolina</creator><creator>Boiroju, Naveen K.</creator><creator>Mokalla, Thirupathi R.</creator><creator>Gadde, Aruna K.</creator><creator>Agraharam, Satish G.</creator><creator>Reddy, G. Bhanuprakash</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4787-3944</orcidid><orcidid>https://orcid.org/0000-0002-6329-7206</orcidid></search><sort><creationdate>202011</creationdate><title>Status of oxidative stress markers, advanced glycation index, and polyol pathway in age-related cataract subjects with and without diabetes</title><author>Chitra, P. Swathi ; Chaki, Debolina ; Boiroju, Naveen K. ; Mokalla, Thirupathi R. ; Gadde, Aruna K. ; Agraharam, Satish G. ; Reddy, G. Bhanuprakash</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-1b2b9395417452e021db9170a26a7c8c42b06e976db80ff6129cb5f5b1aa0453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Advanced glycation index</topic><topic>Age-related cataracts</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aldose reductase</topic><topic>And Sorbitol</topic><topic>Biomarkers - metabolism</topic><topic>Cataract - complications</topic><topic>Cataract - metabolism</topic><topic>Clear lens</topic><topic>Diabetes</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glycation End Products, Advanced - metabolism</topic><topic>Glycosylation</topic><topic>Humans</topic><topic>Lens, Crystalline - metabolism</topic><topic>Lipid Peroxidation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxidative Stress</topic><topic>Polymers - metabolism</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chitra, P. Swathi</creatorcontrib><creatorcontrib>Chaki, Debolina</creatorcontrib><creatorcontrib>Boiroju, Naveen K.</creatorcontrib><creatorcontrib>Mokalla, Thirupathi R.</creatorcontrib><creatorcontrib>Gadde, Aruna K.</creatorcontrib><creatorcontrib>Agraharam, Satish G.</creatorcontrib><creatorcontrib>Reddy, G. Bhanuprakash</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental eye research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chitra, P. Swathi</au><au>Chaki, Debolina</au><au>Boiroju, Naveen K.</au><au>Mokalla, Thirupathi R.</au><au>Gadde, Aruna K.</au><au>Agraharam, Satish G.</au><au>Reddy, G. Bhanuprakash</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Status of oxidative stress markers, advanced glycation index, and polyol pathway in age-related cataract subjects with and without diabetes</atitle><jtitle>Experimental eye research</jtitle><addtitle>Exp Eye Res</addtitle><date>2020-11</date><risdate>2020</risdate><volume>200</volume><spage>108230</spage><epage>108230</epage><pages>108230-108230</pages><artnum>108230</artnum><issn>0014-4835</issn><eissn>1096-0007</eissn><abstract>One of the major public health issues is the rising prevalence of cataracts, a primary reason for preventable blindness. The causes for the development of age-related cataracts and accelerated cataractogenesis in diabetes are multifactorial. Hence, this study was designed to examine the status and relationship between the three majorly associated molecular events, namely, oxidative stress, non-enzymatic glycation, and polyol pathway in age-related cataracts with and without diabetes. A total of 472 subjects were distributed into four groups: non-diabetic subjects with clear lens (135), diabetic subjects with clear lens (40), non-diabetic subjects with cataract (174), and diabetic subjects with cataract (123). Cataracts were graded by slit-lamp examination according to the Lens Opacities Classification System III. Age at onset of cataract, type of opacity, anthropometric measurements, and sociodemographic characteristics were recorded, and clinical profile was examined. Plasma oxidative stress markers were assessed by estimating the lipid peroxidation end product malondialdehyde, protein oxidation products protein carbonyls, and DNA oxidative damage marker 8-hydroxy-2-deoxyguanosine. Plasma advanced glycation end products index, erythrocyte aldose reductase activity, and sorbitol levels were evaluated. After adjusting for age, plasma malondialdehyde levels were significantly higher in diabetic cataracts (P < 0.001) and non-diabetic cataract subjects (P < 0.05), compared to non-diabetic subjects with clear lens. Plasma advanced glycation end products index was significantly higher (P < 0.05) only in diabetic cataracts, but not in non-diabetic subjects with cataracts. Aldose reductase activity and sorbitol levels were significantly higher (P < 0.001) in both diabetic and non-diabetic subjects with cataract compared to non-diabetic subjects with clear lens. The data indicated that plasma lipid peroxidation in age-related cataracts was independent of diabetes. An association of pronounced glycation was observed only in diabetic cataracts but not in non-diabetic cataracts and polyol flux between diabetic cataracts and non-diabetic cataracts was comparable.
•Nuclear cataract was more predominant in both diabetic and non-diabetic subjects.•Lipid peroxidation in age-related cataracts is independent of diabetes.•Only the presence of diabetes augmented plasma advanced glycation index.•Disease-free aging and controlled diabetes activated the polyol pathway equally.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>32931824</pmid><doi>10.1016/j.exer.2020.108230</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-4787-3944</orcidid><orcidid>https://orcid.org/0000-0002-6329-7206</orcidid></addata></record> |
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| subjects | Adult Advanced glycation index Age-related cataracts Aged Aged, 80 and over Aldose reductase And Sorbitol Biomarkers - metabolism Cataract - complications Cataract - metabolism Clear lens Diabetes Diabetes Mellitus - metabolism Female Follow-Up Studies Glycation End Products, Advanced - metabolism Glycosylation Humans Lens, Crystalline - metabolism Lipid Peroxidation Male Middle Aged Oxidative Stress Polymers - metabolism Retrospective Studies |
| title | Status of oxidative stress markers, advanced glycation index, and polyol pathway in age-related cataract subjects with and without diabetes |
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