Site-selective modification of exendin 4 with variable molecular weight dextrans by oxime-ligation chemistry for improving type 2 diabetic treatment

[Display omitted] •Natural biocompatible dextrans were applied for therapeutic peptide modification.•Dextranylation of Ex4 analogs were achieved by site-selective oxime-ligation chemistry.•The long-term hypoglycemic effect is determined by peptide dextranylation site and the size of dextran. Dextran...

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