Discovery of 1-(1H-indazol-4-yl)-3-((1-phenyl-1H-pyrazol-5-yl)methyl) ureas as potent and thermoneutral TRPV1 antagonists

[Display omitted] A series of 1-indazol-3-(1-phenylpyrazol-5-yl)methyl ureas were investigated as hTRPV1 antagonists. The structure–activity relationship study was conducted systematically for both the indazole A-region and the 3-trifluoromethyl/t-butyl pyrazole C-region to optimize the antagonism t...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2020-12, Vol.30 (23), p.127548-127548, Article 127548
Hauptverfasser:	Kang, Jin Mi, Kwon, Sun Ok, Ann, Jihyae, Blumberg, Peter M., Ha, Heejin, Yoo, Young Dong, Frank-Foltyn, Robert, Lesch, Bernhard, Bahrenberg, Gregor, Stockhausen, Hannelore, Christoph, Thomas, Lee, Jeewoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesic TRPV1 Antagonist Vanilloid Receptor 1
Online-Zugang:	Volltext
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