A Multicenter Randomized Prospective Study of Early Cholecystectomy for Pediatric Patients with Biliary Colic
Background In patients with biliary colic, high-quality prospective data supporting the precise timing of cholecystectomy are lacking. The purpose of this study was to determine the effectiveness of early laparoscopic cholecystectomy in children with biliary colic. Methods A multicenter, parallel-gr...
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| Veröffentlicht in: | Journal of gastrointestinal surgery 2021-03, Vol.25 (3), p.713-719 |
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| creator | Gao, Kai Zheng, Chao Han, Huanli Guo, Chunbao |
| description | Background
In patients with biliary colic, high-quality prospective data supporting the precise timing of cholecystectomy are lacking. The purpose of this study was to determine the effectiveness of early laparoscopic cholecystectomy in children with biliary colic.
Methods
A multicenter, parallel-group, randomized study was conducted in patients with biliary colic at 5 hospitals in China. Pediatric patients with biliary colic were prospectively randomized to either the early cholecystectomy or conservative management strategy. The clinical outcomes within 6 months, including the number of biliary colic-free patients and gallstone-related complications, were compared (register number ChiCTR1900021830).
Results
During the first 2 months of follow-up, 71 patients (59.2%, 71/120) receiving conservative management and 124 patients (97.6%, 124/127) in the early cholecystectomy group (
p
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| doi_str_mv | 10.1007/s11605-020-04700-9 |
| format | Article |
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In patients with biliary colic, high-quality prospective data supporting the precise timing of cholecystectomy are lacking. The purpose of this study was to determine the effectiveness of early laparoscopic cholecystectomy in children with biliary colic.
Methods
A multicenter, parallel-group, randomized study was conducted in patients with biliary colic at 5 hospitals in China. Pediatric patients with biliary colic were prospectively randomized to either the early cholecystectomy or conservative management strategy. The clinical outcomes within 6 months, including the number of biliary colic-free patients and gallstone-related complications, were compared (register number ChiCTR1900021830).
Results
During the first 2 months of follow-up, 71 patients (59.2%, 71/120) receiving conservative management and 124 patients (97.6%, 124/127) in the early cholecystectomy group (
p
< 0.001) reported being entirely colic-free. The GIQLI measures were higher in the early cholecystectomy group than in the conservative management group (
p
= 0.032). Acute readmissions occurred in 7 (5.5%) of 127 patients in the early cholecystectomy group, compared with 23 (19.2%) of 120 patients in the conservative management group (risk ratio [RR] 0.25; 95% CI [0.10–0.60],
p
= 0.001) in the 6-month period.
Conclusions
Early cholecystectomy is effective in providing beneficial outcomes in terms of both short-term and long-term improvement of symptoms.</description><identifier>ISSN: 1091-255X</identifier><identifier>EISSN: 1873-4626</identifier><identifier>DOI: 10.1007/s11605-020-04700-9</identifier><identifier>PMID: 32935270</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Abdomen ; Bile ; Child ; Child care ; Children & youth ; China - epidemiology ; Cholecystectomy ; Cholecystectomy, Laparoscopic - adverse effects ; Colic - etiology ; Colic - surgery ; Gallbladder Diseases ; Gallstones ; Gastroenterology ; Hospitals ; Humans ; Laboratories ; Laparoscopy ; Medicine ; Medicine & Public Health ; Original Article ; Outpatient care facilities ; Pain ; Patients ; Pediatrics ; Performance evaluation ; Prospective Studies ; Quality of life ; Surgeons ; Surgery</subject><ispartof>Journal of gastrointestinal surgery, 2021-03, Vol.25 (3), p.713-719</ispartof><rights>The Society for Surgery of the Alimentary Tract 2020</rights><rights>The Society for Surgery of the Alimentary Tract 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-7edf1cc45cab29bef5ce3a263fe3dfe430c70b1ded69d4743ecbba2149f6ca9e3</citedby><cites>FETCH-LOGICAL-c375t-7edf1cc45cab29bef5ce3a263fe3dfe430c70b1ded69d4743ecbba2149f6ca9e3</cites><orcidid>0000-0001-5121-9377</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11605-020-04700-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11605-020-04700-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32935270$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Kai</creatorcontrib><creatorcontrib>Zheng, Chao</creatorcontrib><creatorcontrib>Han, Huanli</creatorcontrib><creatorcontrib>Guo, Chunbao</creatorcontrib><title>A Multicenter Randomized Prospective Study of Early Cholecystectomy for Pediatric Patients with Biliary Colic</title><title>Journal of gastrointestinal surgery</title><addtitle>J Gastrointest Surg</addtitle><addtitle>J Gastrointest Surg</addtitle><description>Background
In patients with biliary colic, high-quality prospective data supporting the precise timing of cholecystectomy are lacking. The purpose of this study was to determine the effectiveness of early laparoscopic cholecystectomy in children with biliary colic.
Methods
A multicenter, parallel-group, randomized study was conducted in patients with biliary colic at 5 hospitals in China. Pediatric patients with biliary colic were prospectively randomized to either the early cholecystectomy or conservative management strategy. The clinical outcomes within 6 months, including the number of biliary colic-free patients and gallstone-related complications, were compared (register number ChiCTR1900021830).
Results
During the first 2 months of follow-up, 71 patients (59.2%, 71/120) receiving conservative management and 124 patients (97.6%, 124/127) in the early cholecystectomy group (
p
< 0.001) reported being entirely colic-free. The GIQLI measures were higher in the early cholecystectomy group than in the conservative management group (
p
= 0.032). Acute readmissions occurred in 7 (5.5%) of 127 patients in the early cholecystectomy group, compared with 23 (19.2%) of 120 patients in the conservative management group (risk ratio [RR] 0.25; 95% CI [0.10–0.60],
p
= 0.001) in the 6-month period.
Conclusions
Early cholecystectomy is effective in providing beneficial outcomes in terms of both short-term and long-term improvement of symptoms.</description><subject>Abdomen</subject><subject>Bile</subject><subject>Child</subject><subject>Child care</subject><subject>Children & youth</subject><subject>China - epidemiology</subject><subject>Cholecystectomy</subject><subject>Cholecystectomy, Laparoscopic - adverse effects</subject><subject>Colic - etiology</subject><subject>Colic - surgery</subject><subject>Gallbladder Diseases</subject><subject>Gallstones</subject><subject>Gastroenterology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Laparoscopy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Outpatient care facilities</subject><subject>Pain</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Performance evaluation</subject><subject>Prospective Studies</subject><subject>Quality of life</subject><subject>Surgeons</subject><subject>Surgery</subject><issn>1091-255X</issn><issn>1873-4626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUuLFDEUhYMozjj6B1xIwI2b0ptHVTrLsRkfMGLjA9yFVHLjZKiqtElKaX-90R4VXLhK4H7nJPccQh4yeMoA1LPC2AB9Bxw6kAqg07fIKdso0cmBD7fbHTTreN9_OiH3SrkGYArY5i45EVyLnis4JfM5fbNONTpcKmb6zi4-zfE7errLqezR1fgV6fu6-gNNgV7YPB3o9ipN6A6ltnGaDzSkTHfoo605OrqzNTa3Qr_FekWfxyna3DRpiu4-uRPsVPDBzXlGPr64-LB91V2-ffl6e37ZOaH62in0gTkne2dHrkcMvUNh-SACCh9QCnAKRubRD9pLJQW6cbScSR0GZzWKM_Lk6LvP6cuKpZo5FofTZBdMazFcyrY_tEAa-vgf9DqteWm_a5TeKL0ZpGoUP1KupVIyBrPPcW57GQbmZxnmWIZpZZhfZRjdRI9urNdxRv9H8jv9BogjUNpo-Yz579v_sf0BjzyW9g</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Gao, Kai</creator><creator>Zheng, Chao</creator><creator>Han, Huanli</creator><creator>Guo, Chunbao</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5121-9377</orcidid></search><sort><creationdate>20210301</creationdate><title>A Multicenter Randomized Prospective Study of Early Cholecystectomy for Pediatric Patients with Biliary Colic</title><author>Gao, Kai ; Zheng, Chao ; Han, Huanli ; Guo, Chunbao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-7edf1cc45cab29bef5ce3a263fe3dfe430c70b1ded69d4743ecbba2149f6ca9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abdomen</topic><topic>Bile</topic><topic>Child</topic><topic>Child care</topic><topic>Children & youth</topic><topic>China - epidemiology</topic><topic>Cholecystectomy</topic><topic>Cholecystectomy, Laparoscopic - adverse effects</topic><topic>Colic - etiology</topic><topic>Colic - surgery</topic><topic>Gallbladder Diseases</topic><topic>Gallstones</topic><topic>Gastroenterology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Laparoscopy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Outpatient care facilities</topic><topic>Pain</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Performance evaluation</topic><topic>Prospective Studies</topic><topic>Quality of life</topic><topic>Surgeons</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Kai</creatorcontrib><creatorcontrib>Zheng, Chao</creatorcontrib><creatorcontrib>Han, Huanli</creatorcontrib><creatorcontrib>Guo, Chunbao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastrointestinal surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Kai</au><au>Zheng, Chao</au><au>Han, Huanli</au><au>Guo, Chunbao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Multicenter Randomized Prospective Study of Early Cholecystectomy for Pediatric Patients with Biliary Colic</atitle><jtitle>Journal of gastrointestinal surgery</jtitle><stitle>J Gastrointest Surg</stitle><addtitle>J Gastrointest Surg</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>25</volume><issue>3</issue><spage>713</spage><epage>719</epage><pages>713-719</pages><issn>1091-255X</issn><eissn>1873-4626</eissn><abstract>Background
In patients with biliary colic, high-quality prospective data supporting the precise timing of cholecystectomy are lacking. The purpose of this study was to determine the effectiveness of early laparoscopic cholecystectomy in children with biliary colic.
Methods
A multicenter, parallel-group, randomized study was conducted in patients with biliary colic at 5 hospitals in China. Pediatric patients with biliary colic were prospectively randomized to either the early cholecystectomy or conservative management strategy. The clinical outcomes within 6 months, including the number of biliary colic-free patients and gallstone-related complications, were compared (register number ChiCTR1900021830).
Results
During the first 2 months of follow-up, 71 patients (59.2%, 71/120) receiving conservative management and 124 patients (97.6%, 124/127) in the early cholecystectomy group (
p
< 0.001) reported being entirely colic-free. The GIQLI measures were higher in the early cholecystectomy group than in the conservative management group (
p
= 0.032). Acute readmissions occurred in 7 (5.5%) of 127 patients in the early cholecystectomy group, compared with 23 (19.2%) of 120 patients in the conservative management group (risk ratio [RR] 0.25; 95% CI [0.10–0.60],
p
= 0.001) in the 6-month period.
Conclusions
Early cholecystectomy is effective in providing beneficial outcomes in terms of both short-term and long-term improvement of symptoms.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32935270</pmid><doi>10.1007/s11605-020-04700-9</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5121-9377</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1091-255X |
| ispartof | Journal of gastrointestinal surgery, 2021-03, Vol.25 (3), p.713-719 |
| issn | 1091-255X 1873-4626 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Abdomen Bile Child Child care Children & youth China - epidemiology Cholecystectomy Cholecystectomy, Laparoscopic - adverse effects Colic - etiology Colic - surgery Gallbladder Diseases Gallstones Gastroenterology Hospitals Humans Laboratories Laparoscopy Medicine Medicine & Public Health Original Article Outpatient care facilities Pain Patients Pediatrics Performance evaluation Prospective Studies Quality of life Surgeons Surgery |
| title | A Multicenter Randomized Prospective Study of Early Cholecystectomy for Pediatric Patients with Biliary Colic |
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