Composition of HBsAg is predictive of HBsAg loss during treatment in patients with HBeAg-positive chronic hepatitis B

During treatment of chronic HBV infections, loss or seroconversion of the HBV surface antigen (HBsAg) is considered a functional cure. HBsAg consists of the large (LHBs), middle (MHBs), and small surface protein (SHBs) and their relative proportions correlate strongly with disease stage. Our aim was...

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Veröffentlicht in:	Journal of hepatology 2021-02, Vol.74 (2), p.283-292
Hauptverfasser:	Pfefferkorn, Maria, Schott, Tina, Böhm, Stephan, Deichsel, Danilo, Felkel, Christin, Gerlich, Wolfram H., Glebe, Dieter, Wat, Cynthia, Pavlovic, Vedran, Heyne, Renate, Berg, Thomas, van Bömmel, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Surface - analysis Antigens, Surface - isolation & purification Antiviral Agents - administration & dosage Biomarkers, Pharmacological - blood ELISA Female HBsAg composition Hepatitis B Hepatitis B e antigen Hepatitis B surface antigen Hepatitis B Surface Antigens - analysis Hepatitis B Surface Antigens - blood Hepatitis B Surface Antigens - immunology Hepatitis B virus - drug effects Hepatitis B virus - immunology Hepatitis B virus - isolation & purification Hepatitis B, Chronic - blood Hepatitis B, Chronic - diagnosis Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - virology Humans Interferon-alpha - administration & dosage LHBs Male MHBs Middle Aged Nucleosides - administration & dosage Patient Acuity Polyethylene Glycols - administration & dosage Predictive Value of Tests preS1 preS2 Recombinant Proteins - administration & dosage Retrospective Studies Seroconversion - drug effects Subviral particles Viral Proteins - analysis Viral Proteins - isolation & purification
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