Enhancing peripheral nerve regeneration with neurotrophic factors and bioengineered scaffolds: A basic science and clinical perspective
Despite the peripheral nervous systems (PNS) capacity to regenerate, functional restoration is highly variable following peripheral nerve injury (PNI), oftentimes leading to persistent functional deficits. In the preclinical arena, advances in the therapeutic use of exogenous neurotrophic factors an...
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| Veröffentlicht in: | Journal of the peripheral nervous system 2020-12, Vol.25 (4), p.320-334 |
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| container_title | Journal of the peripheral nervous system |
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| creator | Lien, Brian V. Brown, Nolan J. Ransom, Seth C. Lehrich, Brandon M. Shahrestani, Shane Tafreshi, Ali R. Ransom, Ryan C. Sahyouni, Ronald |
| description | Despite the peripheral nervous systems (PNS) capacity to regenerate, functional restoration is highly variable following peripheral nerve injury (PNI), oftentimes leading to persistent functional deficits. In the preclinical arena, advances in the therapeutic use of exogenous neurotrophic factors and synthetic neural scaffold technology hold promise in augmenting endogenous PNS regeneration following PNI. Clinical trials utilizing neurotrophic factors for other indications (eg, peripheral neuropathy) may provide insight into their role in PNI. Here we provide an updated review of progress made toward enhancing regeneration after PNI with a focus on neurotrophic factors and bioengineered scaffolds. |
| doi_str_mv | 10.1111/jns.12414 |
| format | Article |
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| identifier | ISSN: 1085-9489 |
| ispartof | Journal of the peripheral nervous system, 2020-12, Vol.25 (4), p.320-334 |
| issn | 1085-9489 1529-8027 |
| language | eng |
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| source | Wiley Online Library All Journals |
| subjects | bioengineered scaffolds Clinical trials neural scaffolds Neurotrophic factors peripheral nerve injury peripheral nerve regeneration peripheral nerve repair Peripheral nerves Peripheral neuropathy Regeneration Tissue engineering |
| title | Enhancing peripheral nerve regeneration with neurotrophic factors and bioengineered scaffolds: A basic science and clinical perspective |
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