Comparison of surfactant-mediated liquid chromatographic modes with sodium dodecyl sulphate for the analysis of basic drugs

In reversed-phase liquid chromatography (RPLC), basic drugs are positively charged at the usual working pH range and interact with free anionic silanols present in conventional silica-based stationary phases. This translates into stronger retention and tailed and broadened peaks. This problem can be...

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Veröffentlicht in:	Analytical methods 2020-05, Vol.12 (19), p.2443-2452
Hauptverfasser:	Pankajkumar-Patel, N, Peris-García, E, Ruiz-Angel, M. J, García-Alvarez-Coque, M. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Additives Adrenergic receptors Antagonists Aqueous solutions Chromatography Chromatography, Liquid Chromatography, Reverse-Phase Drugs Eluents Liquid chromatography Masking Micelles Microemulsions Pollutants Reagents Retention Silica Silicon dioxide Sodium Sodium Dodecyl Sulfate Sodium lauryl sulfate Solutes Solvents Stationary phase Sulfates Surface-Active Agents Surfactants
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