Safety and immunogenicity of co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in Gabonese adults: a randomised, controlled, double-blind, phase 1 dose-escalation trial

Hookworms cause substantial morbidity in children and women of reproductive age. The control strategy of mass drug administration is suboptimal, hence the need for a vaccine. Necator americanus aspartic protease-1 (Na-APR-1) and N americanus glutathione S-transferase-1 (Na-GST-1) are involved in the...

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Veröffentlicht in:	The Lancet infectious diseases 2021-02, Vol.21 (2), p.275-285
Hauptverfasser:	Adegnika, Ayola A, de Vries, Sophia G, Zinsou, Frejus J, Honkepehedji, Yabo J, Dejon Agobé, Jean-Claude, Vodonou, Kafui G, Bikangui, Rodrigue, Bouyoukou Hounkpatin, Aurore, Bache, Emmanuel B, Massinga Loembe, Marguerite, van Leeuwen, Remko, Molemans, Marjan, Kremsner, Peter G, Yazdanbakhsh, Maria, Hotez, Peter J, Bottazzi, Maria Elena, Li, Guangzhao, Bethony, Jeffrey M, Diemert, David J, Grobusch, Martin P, Mouwenda, Yoanne D, Betouke Ongwe, Eunice, Nkoma Mouima, Anne-Marie, Nouatin, Odilon P, Edoa, Jean R, Manouana, Prince G, Pinto de Jesus, Susana, Kühne, Vera, Mordmueller, Benjamin, Lell, Bertrand, Agnandji, Selidji T, Koehler, Carsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Adverse events Aluminum Analysis Anemia Animal models Animals Antibodies Antibodies, Helminth - blood Antigens Aspartic endopeptidase Clinical trials Combined vaccines Detoxification Dose-Response Relationship, Immunologic Double-Blind Method Double-blind studies Drug dosages Female Gabon - epidemiology Gastrointestinal tract Glutathione Glutathione transferase Headache Hemoglobin Hepatitis B Hookworm Infections - epidemiology Hookworm Infections - prevention & control Humans Immunization Immunogenicity Immunoglobulin G Immunoglobulin G - blood Infections Infectious diseases Informed consent Iron Laboratory animals Lipid A Lipids Low income groups Male Morbidity Myalgia Nausea Necator americanus - immunology Proteins Safety Safety analysis Seroconversion Vaccines Vaccines - administration & dosage Vaccines - immunology Young Adult
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