Modulation of Brain Transcriptome by Combined Histone Deacetylase Inhibition and Plasma Treatment Following Traumatic Brain Injury and Hemorrhagic Shock

We previously showed that the addition of valproic acid (VPA), a histone deacetylase inhibitor, to fresh frozen plasma (FFP) resuscitation attenuates brain lesion size and swelling following traumatic brain injury (TBI) and hemorrhagic shock (HS). The goal of this study was to use computational biol...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Shock (Augusta, Ga.) Ga.), 2021-01, Vol.55 (1), p.110-120
Hauptverfasser:	Dekker, Simone E., Biesterveld, Ben E., Bambakidis, Ted, Williams, Aaron M., Tagett, Rebecca, Johnson, Craig N., Sillesen, Martin, Liu, Baoling, Li, Yongqing, Alam, Hasan B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Component Transfusion Brain Injuries, Traumatic - metabolism Brain Injuries, Traumatic - pathology Brain Injuries, Traumatic - prevention & control Disease Models, Animal Enzyme Inhibitors - therapeutic use Female Histone Deacetylase Inhibitors - therapeutic use Plasma Shock, Hemorrhagic - metabolism Shock, Hemorrhagic - pathology Shock, Hemorrhagic - prevention & control Swine Transcriptome - drug effects Valproic Acid - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!