Differences in metabolic and liver pathobiology induced by two dietary mouse models of nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is a growing epidemic linked to metabolic disease. The first stage of NAFLD is characterized by lipid accumulation in hepatocytes, but this can progress into nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). Western diets, hi...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2020-11, Vol.319 (5), p.E863-E876
Hauptverfasser:	Zhang, Hannah, Léveillé, Mélissa, Courty, Emilie, Gunes, Aysim, N Nguyen, Bich, Estall, Jennifer L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cholesterol Cirrhosis Damage Diet Diet, High-Fat Diet, Western Disease Models, Animal Disease Progression Epidemics Fatty liver Female Fibrosis Hepatocellular carcinoma Hepatocytes Hepatocytes - metabolism Hepatocytes - pathology High cholesterol diet High fat diet Homeostasis Lipid Metabolism - physiology Lipids Liver Liver - metabolism Liver - pathology Liver cancer Liver cirrhosis Liver diseases Liver Neoplasms - etiology Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Metabolic disorders Metabolic syndrome Mice Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Pathogenesis Phenotypes Steatosis Sugar
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